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Moonlighting Cell Stress Proteins in Microbial Infections pp 81–91Cite as

Helicobacter pylori Peptidyl Prolyl cis, trans Isomerase: A Modulator of the Host Immune Response

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Part of the book series: Heat Shock Proteins ((HESP,volume 7))

Abstract

Helicobacter pylori is an intriguing bacterium because of its ability to survive at low pH in the stomach and its relationship with gastric inflammation and cancer. Among its armamentarium of virulence factors is HP0175, a peptidylprolyl isomerase (PPIase), which is secreted and is a major antigen in patients with H. pylori-induced pathology. This review summarizes the moonlighting functions of HP0175, revealing that this secreted protein-folding catalyst regulates cell signalling in gastric epithelial cells and in monocytic cells to modulate the inflammatory response and apoptosis during H. pylori infection. In addition, it elicits a Th17 response thereby modulating the adaptive immune response. These activities reveal the importance of protein moonlighting in the generation of H. pylori-induced disease states.

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Acknowledgements

Work from the author’s laboratory was supported by grants from the Indian Council of Medical Research and the Department of Atomic Energy, Government of India.

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  1. Department of Chemistry, Bose Institute, 93/1 Acharya Prafulla Chandra Road, Kolkata, 700009, India

    Manikuntala Kundu

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Correspondence to Manikuntala Kundu .

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  1. Eastman Dental Institute, Div. Microbial Diseases, University College, London, Gray's Inn Road 256, London, WC1X 8LD, United Kingdom

    Brian Henderson

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Kundu, M. (2013). Helicobacter pylori Peptidyl Prolyl cis, trans Isomerase: A Modulator of the Host Immune Response. In: Henderson, B. (eds) Moonlighting Cell Stress Proteins in Microbial Infections. Heat Shock Proteins, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6787-4_5

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