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Listeria monocytogenes and Host Hsp60 – An Invasive Pairing

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Moonlighting Cell Stress Proteins in Microbial Infections

Part of the book series: Heat Shock Proteins ((HESP,volume 7))

Abstract

Microbial infection has a dramatic impact on host cell function and can induce host stress-response programs, including the heat shock response. Listeria monocytogenes is a human foodborne bacterial pathogen which interacts with the host gastrointestinal epithelium during the initial phase of the systemic disease, listeriosis. The early interaction of L. monocytogenes with the intestinal epithelium is a critical determinant of the outcome of infection, and is mediated by multiple bacterial factors, including Listeria adhesion protein (LAP). The epithelial receptor for LAP is human heat shock protein 60 (Hsp60), and the LAP-Hsp60 interaction facilitates bacterial adhesion to and translocation through intestinal epithelial monolayers. Interestingly, L. monocytogenes infection induces the expression of Hsp60 in epithelial cells, a phenomenon which renders host cells more susceptible to subsequent LAP-mediated L. monocytogenes infection. This chapter describes the importance of the host heat shock response during microbial infection, and highlights the role for LAP and host Hsp60 in mediating infection by L. monocytogenes.

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Acknowledgement

Research in Bhunia laboratory is supported by grants from the United States Department of Agriculture (1935-42,000-072-02G; 201,995) and the Center for Food Safety Engineering at Purdue University.

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Authors and Affiliations

  1. Department of Biological Sciences, University of New England, 11 Hills Beach Rd, Biddeford, ME, 04005, USA

    Kristin M. Burkholder

  2. Department of Food Science, Purdue University, 745 Agriculture Mall Drive, West Lafayette, IN, 47907, USA

    Arun K. Bhunia

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Correspondence to Arun K. Bhunia .

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  1. Eastman Dental Institute, Div. Microbial Diseases, University College, London, Gray's Inn Road 256, London, WC1X 8LD, United Kingdom

    Brian Henderson

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Burkholder, K.M., Bhunia, A.K. (2013). Listeria monocytogenes and Host Hsp60 – An Invasive Pairing. In: Henderson, B. (eds) Moonlighting Cell Stress Proteins in Microbial Infections. Heat Shock Proteins, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6787-4_17

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