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The Summary of Stroke and Its Stem Cell Therapy

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Essentials of Mesenchymal Stem Cell Biology and Its Clinical Translation

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Abstract

Stroke is one of the most common diseases affecting human health. It has a high mortality rate and many clinically difficult sequelae such as hemiplegia, numbness, dysphasia and cognitive deficits. Studies have confirmed that stem cells have therapeutic effects following stroke. However, there are still a number of uncertainties for the success of this treatment. What is the mechanism of action? The production of trophic and angiogenic factors or the replacement of the apoptotic or necrotic neurons? Which kind of cell is most suitable for transplantation?

Which is the most appropriate route for transplantation? In this article, we summarize the exiting studies about stem cells for stroke, including animal experiments and clinical trials, to explore the best scheme of stem cell therapy for stroke.

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Author information

Authors and Affiliations

  1. Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, P. R. China

    Renzhi Wang, Ming Feng, Xinjie Bao, Jian Guan & Yang liu

  2. Department of Biochemistry, Dalian Medical University, Dalian, 116044, P. R. China

    Jin Zhang

Authors
  1. Renzhi Wang
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  2. Ming Feng
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  3. Xinjie Bao
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  4. Jian Guan
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  5. Yang liu
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  6. Jin Zhang
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Correspondence to Renzhi Wang .

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Editors and Affiliations

  1. Chinese Academy of Medical Sciences and Peking Union Medical College, Center of Excellence in Tissue Engineering, Institute of Basic Medical Sciences and School of Basic Medicine, 5 Dong Dan San Tiao, Beijing, 100005, China, People's Republic

    Robert Chunhua Zhao

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Wang, R., Feng, M., Bao, X., Guan, J., liu, Y., Zhang, J. (2013). The Summary of Stroke and Its Stem Cell Therapy. In: Zhao, R. (eds) Essentials of Mesenchymal Stem Cell Biology and Its Clinical Translation. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6716-4_16

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