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A Climate and Health Partnership to Inform the Prevention and Control of Meningoccocal Meningitis in Sub-Saharan Africa: The MERIT Initiative

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Abstract

Many human diseases are climate-sensitive: climate acting as an important driver of spatial and seasonal patterns, year-to-year variations (including epidemics), and longer-term trends. Although climate is only one of the many drivers of both infectious and non-infectious disease, public health policy makers and practitioners are increasingly concerned about the potential impact of climate change on the health of populations.

The MERIT Initiative was launched in 2007 to provide a platform for enabling health specialists (public health specialists, epidemiologists, immunologists, microbiologists, demographers, etc.) and climate and environment specialists to work together to help solve a pressing health problem. The main objective of the initiative is to address meningococcal meningitis epidemics in Africa in the context of perceived environmental, biological, economic and demographic influences. The effort is designed to create new knowledge that can be used to improve the current (reactive) and future (preventive) vaccination strategies.

Preliminary results of this research to policy and practice consortium have advanced the understanding of how climate-related information can be tailored to inform and, where possible, strengthen public health decisions. Specifically, the MERIT experience to date indicates new evidence on the contribution that climate and environment make to the spatio-temporal distribution of meningococcal meningitis and demonstrates a multi-sectoral strategic approach to the creation of evidence, together with the development of a cumulative knowledge base. The MERIT Initiative is establishing an effective means for the dissemination of new knowledge and provides a platform to facilitate access to this knowledge by public health practitioners. These developments, along with an increase in the uptake of evidence in both policy and practice have the potential to impact health outcomes in vulnerable at-risk populations in Africa’s Meningitis Belt.

The collaborative partnership model of MERIT provides an innovative framework to support public health preparedness and control strategies for climate sensitive diseases. Public health decision-makers have been willing to explore unfamiliar territory and opportunities for improving well-established control strategies by leveraging new knowledge and expertise from other disciplinary communities including climate and environmental researchers. Equally important have been the investments made by a multi-disciplinary research and practice community to adapt research projects in line with the evolving public health strategy across the Meningitis Belt. The lessons learned from the MERIT project offer valuable input and new ideas for improving global public health strategies for other climate and environmentally sensitive epidemic prone diseases.

All rights reserved. The World Health Organization has granted the Publisher permission for the reproduction of this chapter.

The authors Stéphane Hugonnet, Emily Firth and William Perea are (or were at the time of writing) staff member of the World Health Organization. These authors alone are responsible for views expressed in this publication and they do not necessarily represent the decisions or policies of the World Health Organization.

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References

  • Agier L, Stanton M, Diggle PJ (2012) A multi-state spatiotemporal Markov model for categorized incidence of meningitis in Sub-Saharan Africa. Epidemiology and Infection 21:1–8

    Google Scholar 

  • Agier L, Deroubaix A, Martiny N, Yaka P, Djibo A, Broutin H (2013) Seasonality of meningitis in Africa and climate forcing: aerosols stand out. J R Soc Interface 10(79):20120814

    Article  CAS  Google Scholar 

  • Anon (2000) The use of polysaccharide trivalent ACW vaccine for the control of epidemic meningococcal meningitis disease outbreaks in countries of the African meningitis belt. Wkly Epidemiol Rec 75:306–309

    Google Scholar 

  • Beresniak A, Bertherat E, Perea W, Soga G, Souley R, Duponte D, Hugonnet S (2012) A Bayesian network approach to the study of historical epidemiological databases: modelling meningitis outbreaks in the Niger. Bulletin of the World Health Organization, 1/90(6):412-417A. doi:10.2471/BLT.11.086009

    Google Scholar 

  • Besancenot JP, Boko M, Oke PC (1997) Weather conditions and cerebrospinal meningitis in Benin (Gulf of Guinea, West Africa). Eur J Epidemiol 13:807–815

    Article  CAS  Google Scholar 

  • Bharti N, Broutin H, Grais RF, Ferrari MJ, Djibo A, Tatem AJ, Grenfell BT (2011) Spatial dynamics of meningococcal meningitis in Niger: observed patterns in comparison with measles’. Epidemiol Infect 140(8):1356–1365, Epidemiology and Infection, 1–10

    Article  Google Scholar 

  • Cheesbrough JS, Morse AP, Green SDR (1995) Meningococcal meningitis and carriage in Western Zaire – a hypoendemic zone related to climate. Epidemiol Infect 114:75–92

    Article  CAS  Google Scholar 

  • Colombini A (2009) Cost for household and community perception of meningitis epidemics in Burkina Faso. Clin Infect Dis 49:1520–1525

    Article  Google Scholar 

  • Colombini A, Badolo O, Gessner BD, Jaillard P, Seini E, Da Silva A (2011) Costs and impact of meningitis epidemics on the public health system i Burkina Faso. Vaccine 29:5474–5480

    Article  Google Scholar 

  • Cuevas L, Hart CA, Thomson MC (2008) Climate and environmental information and the control of epidemic meningitis in Africa. In: Thomson MC, Herrera RG, Beniston M (eds) Seasonal forecasts, climatic change and human health. Springer, Dordrecht, pp 85–100

    Chapter  Google Scholar 

  • Cuevas E, Pérez C, Baldasano JM, Camino C, Alonso-Pérez S, Basart S (2011) MACC O-INT WP3.1 “Meningitis linked to mineral dust transport in the Sahel”. http://sds-was.aemet.es/projects-research/MACCOINTWP3.1SeconddeliveryReport_Final.pdf

  • Del Corral J, Blumenthal MB, Mantilla G, Ceccato P, Connor SJ, Thomson MC (2012) Climate information for public health: the role of the IRI climate data library in an integrated knowledge system. Geosp Health 6(3):S15–S24

    Google Scholar 

  • Dukic V, Hayden M, Adams Forgor A, Hopson T, Akweongo P, Hodgson A, Wiedinmyer C, Yoksas T, Thomson M, Trzaska S, Pandya R (2012) The role of weather in meningitis outbreaks in Navrongo, Ghana: a generalized additive modeling approach. J Agric Biol Environ Stat 17:442–460. doi:10.1007/s13253-012-0095-9

    Article  Google Scholar 

  • Greenwood B (1999) Meningococcal meningitis in Africa. Trans R Soc Trop Med Hyg 93:341–353

    Article  CAS  Google Scholar 

  • Greenwood BM, Bradley AK, Wall RA (1985) Meningococcal disease and season in sub-Saharan Africa. Lancet 2:829–830

    Article  CAS  Google Scholar 

  • Haustein K, Coauthors (2012) Atmospheric dust modeling from meso to global scales with the online NMMB/BSC-Dust model – part 2: experimental campaigns in Northern Africa. Atmos Chem Phys 12:2933–2958

    Google Scholar 

  • Irving TJ, Blyuss K, Colijn C, Trotter CL (2011) Modelling meningococcal meningitis in the African meningitis belt. Epidemiol Infect, 1–9

    Google Scholar 

  • Kelly-Hope L, Thomson MC (2008) Climate and infectious diseases. In: Thomson MC, Herrera RG, Beniston M (eds) Seasonal forecasts, climatic change and human health. Springer, Dordrecht, pp 31–70

    Chapter  Google Scholar 

  • Lapeyssonnie L (1963) La méningite cérébro-spinale en Afrique. Bull World Health Org 28:53–114

    Google Scholar 

  • MERIT (2008) Report of the 2nd MERIT technical meeting and Ethiopian workshop, 45 pp

    Google Scholar 

  • MERIT (2009) Report of the third MERIT technical meeting and national workshop Niger, 55 pp

    Google Scholar 

  • MERIT (2010) Report of the 4th MERIT technical meeting, 59 pp

    Google Scholar 

  • Molesworth A, Cuevas LE, Connor SJ, Morse AP, Thomson MC (2003) Environmental risk and meningitis epidemics in Africa. Emerg Infect Dis 9:1287–1293

    Article  Google Scholar 

  • Moore PS, Coauthors (1992) Detection of meningitis epidemics in Africa: a population-based analysis. Int J Epidemiol 21:155–162

    Google Scholar 

  • Mueller J, Gessner BD (2010) A hypothetical explanatory model for meningococcal meningitis in the African meningitis belt. Int J Infect Dis 14:e553–e559

    Article  Google Scholar 

  • Mueller JE, Coauthors (2008) Association of respiratory tract infection symptoms and air humidity with meningococcal carriage in Burkina Faso. Trop Med Int Health 13:1543–1552

    Google Scholar 

  • Nickovic S, Vukovic A, Vujadinovic M, Djurdjevic V, Pejanovic G (2011) Technical note: minerals in dust productive soils – impacts and global distribution. Atmos Chem Phys: Discuss 11:26009–26034

    Article  Google Scholar 

  • Nickovic S, Vukovic A, Vujadinovic M, Djurdjevic V, Pejanovic G (2012) Technical note: high-resolution mineralogical database of dust-productive soils for atmospheric dust modeling. Atmos Chem Phys 12:845–855

    Article  CAS  Google Scholar 

  • Noinaj N, Coauthors (2012) Structural basis for iron piracy by pathogenic Neisseria. Nature 483:53–58

    Google Scholar 

  • Paireau J, Girond F, Collard J-M, Maïnassara HB, Jusot J-F (2011) Analysing spatio-temporal clustering of meningococcal meningitis outbreaks in Niger reveals opportunities for improved disease control. PLoS Negl Trop Dis 6:e1577

    Article  Google Scholar 

  • Pérez C, Baldasano JM, Jiménez-Guerrero P, Jorba O, Haustein K, Cuevas E, Basart S, Nickovic S (2009) Dust modelling and forecasting in the Barcelona supercomputing center: activities and developments. WMO/GEO expert meeting on an international sand and dust storm warning system. IOP Publishing. IOP Conf Ser: Earth Environ Sci 7:012013. doi:10.1088/1755-1307/7/1/012013

  • Pérez C, Haustein K, Janjic Z, Jorba O, Huneeus N, Baldasano JM, Black T, Basart, Nickovic S, Miller RL, Perlwitz JP, M. Schulz M, Thomson M (2011) Atmospheric dust modeling from meso to global scales with the online NMMB/BSC-Dust model: 1. Model description, annual simulations and evaluation. Atmos Chem Phys Discuss 11:13001–13027

    Google Scholar 

  • Roberts L (2008) An ill wind, bringing meningitis. Science 320:1710–1715

    Article  CAS  Google Scholar 

  • Sow SO, Coauthors (2011) Immunogenicity and safety of a meningococcal a conjugate vaccine in Africans. N Engl J Med 364:2293–2304

    Google Scholar 

  • Stanton M (2012) Chapter 5 exploring the relationship between meningitis incidence and climatic factors in Niger, West Africa’. In: Spatial and spatio-temporal statistical methods and their applications in epidemiology. School of Medicine, University of Lancaster, Lancashire, UK

    Google Scholar 

  • Stanton M, Diggle P, Perez C, Trzaska S, Thomson M (2011) Exploring the relationship between meningitis incidence and climatic factors is Niger, West Africa. In: 17th European young statisticians meeting, Lisbon, Portugal, 5–9 Sept 2011

    Google Scholar 

  • Sultan B (2005) Influence of climate upon the meningitis onset in West Africa. M S-Med Sci 21:470–471

    Google Scholar 

  • Sultan B, Labadi K, Guegan JF, Janicot S (2005) Climate drives the meningitis epidemics onset in West Africa. Plos Med 2:43–49

    Article  Google Scholar 

  • Thomson MC, Molesworth AM, Djingarey MH, Yameogo KR, Belanger F, Cuevas LE (2006) Potential of environmental models to predict meningitis epidemics in Africa. Trop Med Int Health 11:781–788

    Article  Google Scholar 

  • Thomson MC, Jeanne I, Djingarey M (2009) Dust and epidemic meningitis in the Sahel: a public health and operational research perspective. IOP Conf Ser: Earth Environ Sci 7:4

    Article  Google Scholar 

  • Trzaska S, Perez C, Thomson M (2010) The role of intraseasonal atmospheric variability in meningitis outbreaks in the Sahel – 2010 vs. 2009 case study. In: Progress report to NOAA NA05OAR4311004 1 Nov 2009–31 Oct 2010, pp 57–58

    Google Scholar 

  • WHO (2007) Risk of meningitis epidemic in Africa: a cause for concern. Wkly Epidemiol Rec 82:79–87

    Google Scholar 

  • Yaka P, Sultan B, Broutin H, Janicot S, Philippon S, Fourquet N (2008) Relationships between climate and year-to-year variability in meningitis outbreaks: a case study in Burkina Faso and Niger. Int J Heal Geogr 7:13

    Article  Google Scholar 

Download references

Acknowledgements

The MERIT Steering Committee thanks the broad stakeholder community represented by the names of those included in the many presentations associated with MERIT Technical Meetings for their comments on this report. The individuals and research groups draw on a wide range of funding sources to support their work. The MERIT Steering Committee is grateful to all MERIT partners who have shared their experiences and insights into the MERIT Initiative to date, and to Dr. David Rogers of the Health and Climate Foundation for facilitating the partnership network and communications activities. The discussions with partners and views expressed have been a valuable part of the MERIT Situational Analysis initially presented at the World Climate Research Programme (WCRP) Open Science Conference in October 2011 and as described in this chapter. The full list of MERIT partners as well as MERIT meeting reports and related publications are available on the MERIT website at http://merit.hc-foundation.org/.

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Correspondence to Madeleine C. Thomson .

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Thomson, M.C. et al. (2013). A Climate and Health Partnership to Inform the Prevention and Control of Meningoccocal Meningitis in Sub-Saharan Africa: The MERIT Initiative. In: Asrar, G., Hurrell, J. (eds) Climate Science for Serving Society. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6692-1_17

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