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Disturbance of Hereditary Material Reserves Is the Main Instrument of Stress

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Radiation-Induced Processes of Adaptation

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Abstract

This review presents data on the low-dose radiation effects and their mathematical models. Its purpose is to demonstrate that radiation stress leads to processes of instability that can be revealed as different phenomena. The phenomena of radioadaptation, nonlinear response induced by low-dose irradiation, hormetic effect, and continued instability across generations, and stimulation of proliferation are considered. Our special interest is the investigation of the bystander effect which clarified some of these phenomena. The regularities of the bystander effect, genomic and transgenerational instability are considered. The modelling of these radiation effects is discussed: the models offered by Yu.G. Kapultsevich (probabilistic), D.J. Brenner et al. (“Bystander and Direct”), H. Nikjoo and I.K. Khvostunov (Diffusion model), and B.E. Leonard (“Microdose Model”) are presented. The investigations of Russian scientists and the Timofeeff-Ressovsky school are presented as being of special interest to Western scientists owing to this information not having been published in the West due to the cold war.

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Notes

  1. 1.

    Here we consider the changes of cells and chromosomes.

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Authors and Affiliations

  1. Joint Institute for Nuclear Research, Moscow, Russia

    Victoria L. Korogodina & Boris V. Florko

  2. Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia

    Ludmila P. Osipova

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  1. Victoria L. Korogodina
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  2. Boris V. Florko
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  3. Ludmila P. Osipova
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Korogodina, V.L., Florko, B.V., Osipova, L.P. (2013). Disturbance of Hereditary Material Reserves Is the Main Instrument of Stress. In: Radiation-Induced Processes of Adaptation. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6630-3_2

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