Abstract
The extraction of Fallopia sachalinensis leaves resulted in two fractions (FS-1 and FS-2). Chemical and spectral analyses of samples revealed the prevalence of pectic polysaccharides with high galacturonic acid, arabinose, galactose, and rhamnose content. Arabinogalactan with a higher content of phenolic prevailed in the FS-1, whereas rhamnogalacturonan predominated in the FS-2 fraction. Both polysaccharides showed significant antioxidant activity according to DPPH and FRAP assays. Evaluation of antitussive activity in healthy adult conscious guinea pigs after oral application of 50 and 75 mg/kg of the FS-2 polysaccharide extracts showed a significant suppression of cough reflex, without an influence on specific airway resistance. The suppression of cough was comparable with that of codeine.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Capek, P., Machova, E., & Turjan, J. (2009). Scavenging and antioxidant activities of immunomodulating polysaccharides isolated from Salvia officinalis L. International Journal of Biological Macromolecules, 44, 75–80.
El-Hashim, A. Z., Edafiogho, I. O., Jaffal, S. M., Yousif, M. H., Ezeamuzie, C. I., & Kombian, S. B. (2011). Anti-tussive and bronchodilator mechanisms of action for the enaminone E121. Life Sciences, 89, 378–387.
El-Hawary, S. A., Sokkar, N. M., Ali, Z. Y., & Yehia, M. M. (2011). A profile of bioactive compounds of rumex vesicarius L. Journal of Food Science, 76, C1195–C1202.
Hromadkova, Z., Hirsch, J., & Ebringerova, A. (2010). Chemical evaluation of Fallopia species leaves and antioxidant properties of their non-cellulosic polysaccharides. Chemical Papers, 64, 663–672.
Hu, S. (1993). A comment on two medicinal aroids Huzhang and Tiananxing. Zhongguo Zhong Yao Za Zhi, 18, 195–196 (in Chinese).
Jakus, J., Poliacek, I., Halasova, E., Murin, P., Knocikova, J., Tomori, Z., & Bolser, D. C. (2008). Brainstem circuitry of tracheal-bronchial cough: c-fos study in anesthetized cats. Respiratory Physiology & Neurobiology, 160, 289–300.
Kardosova, A., & Machova, E. (2006). Antioxidant activity of medicinal plant polysaccharides. Fitoterapia, 77, 367–373.
Kostalova, Z., Hromadkova, Z., & Ebringerova, A. (2010). Isolation and characterization of pectic polysaccharides from the seeded fruit of oil pumpkin (Cucurbira pepo L. var. Styriaca). Industrial Crops and Products, 31, 370–377.
Lin, C. L., Wang, C. C., Chang, S. C., Inbaraj, B. S., & Chen, B. H. (2009). Antioxidative activity of polysaccharide fractions isolated from Lycium barbarum Linnaeus. International Journal of Biological Macromolecules, 45, 146–151.
Nino-Medina, G., Carvajal-Millan, E., Rascon-Chu, A., Marquez-Escalante, J. A., Guerrero, V., & Salas-Munoz, E. (2010). Feruloylated arabinoxylans and arabinoxylan gels: Structure, sources and applications. Phytochemistry Reviews, 9, 111–120.
Nosalova, G., Capek, P., Sutovska, M., Franova, S., & Matulova, M. (2006). Antitussive active polysaccharides from ornamental-medicinal plants. In J. A. Teixeira da Silva (Ed.), Floriculture, ornamental and plant biotechnology (pp. 471–480). Middlesex: Global Science Books.
Nosalova, G., Capek, P., Fleskova, D., Jurecek, L., Hindak, F., Lukavsky, J., Cepak, V., Ray, B., Breierova, E., & Turjan, J. (2011a). Influence of viscous Rhodella grisea (Rhodophyceae) proteoglycan on chemically induced cough reflex. International Journal of Biological Macromolecules, 49, 1046–1050.
Nosalova, G., Prisenznakova, L., Kostalova, Z., Ebringerova, A., & Hromadkova, Z. (2011b). Suppressive effect of pectic polysaccharides from Cucurbita pepo L. var. Styriaca on citric acid-induced cough reflex in guinea pigs. Fitoterapia, 82, 357–364.
Ogwuru, N., & Adamzenski, M. (2000). Bioactive natural products derived from polygonum species of plants: Their structure and mechanisms of action. Studies in Natural Products Chemistry, 22(3), 607–642.
Pennock, B. E., Cox, C. P., Rogers, R. M., Cain, W. A., & Wells, J. H. (1979). A noninvasive technique for measurement of changes in specific airway resistance. Journal of Applied Physiology, 46, 399–406.
Rao, R. S. P., & Muralikrishna, G. (2006). Water soluble feruloyl arabinoxylans from rice and ragi: Changes upon malting and their consequence on antioxidant activity. Phytochemistry, 67, 91–99.
Shen, M. Y., Liu, Y. J., Don, M. J., Liu, H. Y., Chen, Z. W., Mettling, C., Corbeau, P., Chiang, C. K., Jang, Y. S., Li, T. H., Young, P., Chang, C. L., Lin, Y. L., & Yang, W. C. (2011). Combined phytochemistry and chemotaxis assays for identification and mechanistic analysis of anti-inflammatory phytochemicals in Fallopia japonica. PLoS One, 6, e27480.
Silva, D. C., Freitas, A. L. P., Pessoa, C. D. S., Paula, R. C. M., Mesquita, J. X., Leal, L. K. A. M., Brito, G. A. C., Gonçalves, D. O., & Viana, G. S. B. (2011). Pectin from Passiflora edulis shows anti-inflammatory action as well as hypoglycemic and hypotriglyceridemic properties in diabetic rats. Journal of Medicinal Food, 14, 1118–1126.
Simera, M., Poliacek, I., & Jakus, J. (2010). Central antitussive effect of codeine in the anesthetized rabbit. European Journal of Medical Research, 15, 184–188.
Sinha, S., Nosalova, G., Bandyopadhyay, S. S., Fleskova, D., & Ray, B. (2011). In vivo anti-tussive activity and structural features of a polysaccharide fraction from water extracted Withania somnifera. Journal of Ethnopharmacology, 134, 510–513.
Sutovska, M., Nosalova, G., Franova, S., & Kardosova, A. (2007). The antitussive activity of polysaccharides from Althaea officinalis l., var. Robusta, Arctium lappa L., var. Herkules, and Prunus persica L., Batsch. Bratislavske Lekarske Listy, 108, 93–99.
Sutovska, M., Franova, S., Priseznakova, L., Nosalova, G., Togola, A., Diallo, D., Paulsen, B. S., & Capek, P. (2009). Antitussive activity of polysaccharides isolated from the Malian medicinal plants. International Journal of Biological Macromolecules, 44, 236–239.
Thirawong, N., Nunthanid, J., Puttipipatkhachorn, S., & Sriamornsak, P. (2007). Mucoadhesive properties of various pectins on gastrointestinal mucosa: An in vitro evaluation using texture analyzer. European Journal of Pharmaceutics and Biopharmaceutics, 67, 132–140.
Widdicombe, J. G., & Ernst, E. (2009). Clinical cough V: Complementary and alternative medicine: Therapy of cough. Handbook of Experimental Pharmacology, 187, 321–342.
Zhou, Q., Tian, X. F., Gong, X. Y., Feng, Y. L., & Hu, H. (2011). Effects of jiawei huzhang san decoction on the expressions of inflammatory factors MCP-1 and PDGF-BB in rat models of experimental autoimmune prostatitis. Zhonghua nan ke xue, 17, 83–88 (in Chinese).
Acknowledgements
Supported by the Slovak Research and Development Agency (APVV) Grant LPP-0317-09 and Grant 0030-07. This contribution is also a result of the projects ‘Center of Experimental and Clinical Respirology II’ and ‘Support of human resources development using the most modern methods and forms of education’ co-financed from the EU sources.
Conflicts of Interests
The authors declare no conflicts of interest in relation to this article.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Nosalova, G., Jurecek, L., Hromadkova, Z., Kostalova, Z., Sadlonova, V. (2013). Antioxidant Activity of Herbal Polysaccharides and Cough Reflex. In: Pokorski, M. (eds) Neurobiology of Respiration. Advances in Experimental Medicine and Biology, vol 788. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6627-3_8
Download citation
DOI: https://doi.org/10.1007/978-94-007-6627-3_8
Published:
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-007-6626-6
Online ISBN: 978-94-007-6627-3
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)