Abstract
The understanding the functional expression of exhaled volatile organic compounds (VOCs) has gradually expanded from the initial identification of breath pathological markers to direct expression of physiological activity. In the present study we investigated the potential application of breath analysis in real-time monitoring of type 2 diabetes mellitus (T2DM) patients versus control subjects while performing a cognitive task. T2DM is associated with cognitive impairment and neural deficits, because of insulin resistance and high expression of insulin receptors in the hippocampus. We set out to seek the evidence for mutual associations among breath exhale, on the one side, and T2DM and cognitive effort, on the other side. The recording system consisted of a metal oxide semiconductor (MOS) which is able to detect a broad range of volatile organic compounds. The sensor provides a measure of VOCs as ppm CO2 equivalents. The MOS is suitable for a non-invasive real-time monitoring of the breath exhale in humans. The study demonstrates that, apart from the T2DM metabolic derangement, performing a cognitive task, taken as an index of central neural effort, evoked distinct alterations in exhaled breath content. We conclude that exhaled breath content measurement might offer a novel diagnostic and therapeutic non-invasive approach in metabolic and neurodegenerative derangements.
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References
Biessels, G. J., Deary, I. J., & Ryan, C. M. (2008). Cognition and diabetes: A lifespan perspective. Lancet Neurology, 7, 184–190.
Bruehl, H., Wolf, O. T., Sweat, V., Tirsi, A., Richardson, S., & Convit, A. (2009). Modifiers of cognitive function and brain structure in middle-aged and elderly individuals with type 2 diabetes mellitus. Brain Research, 1280, 186–194.
Conkle, J. P., Camp, B. J., & Welch, B. E. (1975). Trace composition of human respiratory breath. Archives of Environmental Health, 30, 290–295.
Cukierman, T., Gerstein, H. C., & Williamson, J. D. (2005). Cognitive decline and dementia in diabetes – Systematic overview of prospective observational studies. Diabetologia, 48, 2460–2469.
Gold, S., Dziobek, I., Sweat, V., Tirsi, A., Rogers, K., Bruehl, H., Tsui, W., Richardson, S., Javier, E., & Convit, A. (2007). Hippocampal damage and memory impairments as possible early brain complications of type 2 diabetes. Diabetologia, 50, 711–719.
Ketterer, C., Tschritter, O., Preissl, H., Henia, M., Häringa, H., & Fritsche, A. (2011). Insulin sensitivity of the human brain. Diabetes Research and Clinical Practice, 93, 47–51.
Mazzatenta, A., Di Giulio, C., & Pokorski, M. (2013a). Pathologies currently identified by exhaled biomarkers. Respiratory Physiology & Neurobiology, doi: 10.1016/j.resp.2013.02.016. (Epub ahead of print).
Mazzatenta, A., Pokorski, M., Cozzutto, S., Barbieri, P., Veratti, V., & Di Giulio, C. (2013b). Non-invasive assessment of exhaled breath pattern in patients with multiple chemical sensibility disorder. Advances in Experimental Medicine and Biology, 756, 179–188.
McCrimmon, R. J., Ryan, C. M., & Frier, B. M. (2012). Diabetes and cognitive dysfunction. Lancet, 379(9833), 2291–2299.
McNay, E. C., Ong, C. T., McCrimmon, R. J., Cresswell, J., Bogan, J. S., & Sherwin, R. S. (2010). Hippocampal memory processes are modulated by insulin and high-fatigue-induced insulin resistance. Neurobiology of Learning and Memory, 93(4), 546–553.
McNay, E. C., & Recknagel, A. K. (2011). Brain insulin signaling: A key component of cognitive processes and a potential basis for cognitive impairment in type 2 diabetes. Neurobiology of Learning and Memory, 96(3), 432–442.
Phillips, M., Cataneo, R. N., Cheem, T., & Greenberg, J. (2004). Increased breath biomarkers of oxidative stress in diabetes mellitus. Clinica Chimica Acta, 344, 189–194.
Solga, S. F., & Risby, T. H. (2010). What is normal breath? Challenge and opportunity. IEEE Sensors, 10, 7–9.
Vijan, S. (2010). Type 2 diabetes. Annals of Internal Medicine, 152(5), ITC3 1–15.
West, I. C. (2000). Radicals and oxidative stress in diabetes. Diabetes Medicine, 17, 171–180.
Williamson, R., McNeilly, A., & Sutherland, C. (2012). Insulin resistance in the brain: An old-age or new-age problem? Biochemical Pharmacology, 84, 737–745.
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Mazzatenta, A., Pokorski, M., Di Giulio, C. (2013). Real-Time Breath Analysis in Type 2 Diabetes Patients During Cognitive Effort. In: Pokorski, M. (eds) Neurobiology of Respiration. Advances in Experimental Medicine and Biology, vol 788. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6627-3_35
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DOI: https://doi.org/10.1007/978-94-007-6627-3_35
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