Abstract
The aim of the study was to describe the course of influenza among children aged 0–59 months. A total of 150 children with influenza-like symptoms (ILI): cough, fever >37.8 °C, and sore throat was included into the observation. All children were tested with both rapid influenza detection test (RIDT) BD Directigen™ EZ Flu A+B® and RT-PCR. Sixty four cases of influenza were diagnosed (incidence rate 40 %): 19 (30 %) cases of influenza caused by type B virus and 45 (70 %) cases caused by type A virus. Children with influenza required more often follow up visits (p < 0.05, OR 1.99, 95 % CI 1.03–3.85) and less often were administrated antibiotic therapy (p < 0.05, OR 0.25, 95 % CI 0.04–0.97). The logistic regression analysis revealed that only positive result of rapid influenza detection test, not any of clinical symptoms, could be found as an independent predictor of influenza (OR 4.37, 95 % CI 2.03–9.43). Patients with influenza type A more often reported muscle ache (p < 0.05) and complications (p < 0.05; OR 6.06, 95 % CI 1.20–60.38). Otitis media occurred more often among patients with than without influenza (p < 0.01; OR 15.50, 95 % CI 2.10–688.5). We conclude that although influenza infections among children younger than 59 months were generally mild and self-limited, pediatric burden of the disease was significant.
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References
Bhat, N., Wright, J., Broder, K., Murray, E., Greenberg, M., Glover, M., Likos, A., Posey, D., Klimov, A., Lindstrom, S., Balish, A., Medina, M., Wallis, T., Guarner, J., Paddock, C., Shieh, W., Zaki, S., Sejvar, J., Shay, D., Harper, S., Cox, N., Fukuda, K., & Uyeki, T. (2005). Influenza special investigation team: Influenza-associated deaths among children in the United States. New England Journal of Medicine, 353(24), 2559–2567.
Chi, C., Wang, S., Lin, C., Wang, H., Wang, J., Su, I., & Liu, C. (2008). Clinical features of children infected with different strains of influenza B in southern Taiwan. The Pediatric Infectious Disease Journal, 27(7), 640–645.
D’Onise, K., & Raupach, J. (2008). The burden of influenza in healthy children in South Australia. The Medical Journal of Australia, 8, 510–513.
Daley, A., Nallusamy, R., & Isaacs, D. (2000). Comparison of influenza A and influenza B virus infection in hospitalized patients. Journal of Paediatrics and Child Health, 36(4), 332–335.
De La Rocque, F., Lecuyer, A., Wollner, C., d’Athis, P., Thollot, F., & Cohen, R. (2009). Impact of influenza rapid diagnostic tests (IRDT) on the diagnosis of influenza and on the management of influenza in children in ambulatory pediatric setting. Archives of Pediatrics, 16(3), 288–293.
Dilantika, C., Sedyaningsih, E., Kasper, M., Agtini, M., Listiyaningsih, E., Uyeki, T., Burgess, T., Blair, P., & Putnam, S. (2010). Influenza virus infection among pediatric patients reporting diarrhea and influenza-like illness. BMC Infectious Diseases, 10, 3. doi:10.1186/1471-2334-10-3.
Esposito, S., Cantarutti, L., Molteni, C., Daleno, C., Scala, A., Tagliabue, C., Pelucchi, C., Giaquinto, C., & Principi, N. (2011a). Clinical manifestations and socio-economic impact of influenza among healthy children in the community. The Journal of Infection, 62(5), 379–387.
Esposito, S., Molteni, C., Daleno, C., Valzano, A., Fossali, E., Da Dalt, L., Cecinati, V., Bruzzese, E., Giacchino, R., Giaquinto, C., Lackenby, A., & Principi, N. (2011b). Clinical and socioeconomic impact of different types and subtypes of seasonal influenza viruses in children during influenza seasons 2007/2008 and 2008/2009. BMC Infectious Diseases, 11, 271.
Gutierrez, C., Nazar, G., & Torres, J. (2011). Otolaryngological complications in patients infected with influenza A(H1N1) virus. Otolaryngology-Head and Neck Surgery, 13, 23–26.
Heikkinen, T. (2006). Influenza in children. Acta Paediatrica, 95, 778–784.
Jennings, L. C., Skopnik, H., Burckhardt, I., Hribar, I., Piero, L., & Deichmann, K. A. (2009). Effect of rapid influenza testing on clinical management of paediatric influenza. Influenza and Other Respiratory Viruses, 3(3), 91–98. doi:10.1111/j.1750-2659.2009.00079.x.
Mall, S., Buchholz, U., Tibussek, D., Jurke, A., An der Heiden, M., Diedrich, S., Schweiger, B., & Alpers, K. (2011). A large outbreak of influenza B-associated benign acute childhood myositis in Germany, 2007/2008. Pediatric Infectious Disease, 30(8), 142–146.
Nitsch-Osuch, A., Brydak, L., & Wardyn, K. (2008). Neuraminidase inhibitors in prophylaxis and treatment of influenza. Polski Merkuriusz Lekarski, 25(1450), 167–173.
Nitsch-Osuch, A., Kuchar, E., Zycinska, K., Topczewska-Cabanek, A., Gyrczuk, E., & Wardyn, K. (2010). Influenza vaccine coverage among children under the age of 5 years in Poland during 2004–2008. European Journal of Medical Research, 15(Suppl 2), 102–104.
Quach, C., Piché-Walker, L., Platt, R., & Moore, D. (2003). Risk factors associated with severe influenza infections in childhood: Implication for vaccine strategy. Pediatrics, 112, 197–201.
Rojo, J., Ruiz-Contreras, J., Fernandez, M., Marin, M., & Folgueira, L. (2006). Influenza related hospitalizations in children younger than three years of age. The Pediatric Infectious Disease Journal, 25, 596–601.
Rothberg, M., Haessler, S., & Brown, R. (2008). Complications of viral influenza. The American Journal of Medicine, 121, 258–264.
Shiley, K., Nadolski, G., Mickus, T., Fishman, O., & Lauterbach, E. (2010). Differences in the epidemiological characteristics and clinical outcomes of pandemic (H1N1)2009 influenza, compared with seasonal influenza. Infection Control and Hospital Epidemiology, 31(7), 676–682.
Shin, S., Gwack, J., Hyung, J., Kim, H., Kang, Y., Lee, H., Kim, J., Lee, J., & Kim, S. (2011). Drug-resistance pandemic (H1N1) 2009 South Korea. Emerging Infectious Diseases, 17(4), 702–704.
Tsolia, M., Logotheti, I., Paradopolous, N., Mavrikou, M., Spyridis, N., Drossatou, P., Kafetzis, D., & Konstantopoulos, A. (2006). Impact of influenza infection in healthy children examined as outpatients and their families. Vaccine, 24, 5970–5976.
United States Centers for Disease Control and Prevention (2009). Antiviral treatment options including intravenous Peramivir for treatment of influenza in hospitalized patients for 2009–2010 season. http://www.cdc.gov.H1N1flu/EUA/Peramivir-recommendations.html. Accessed on 7 Nov 2012.
WHO. CDC Realtime RTPCR (rRTPCR) Protocol for detection and characterization of swine influenza (2009). CDC protocol of realtime RTPCR for swine influenza A(H1N1). http://www.who.int/csr/resources/publications/swineflu/CDCrealtimeRTPCRprotocol_20090428.pdf. Accessed on 7 Nov 2012.
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Nitsch-Osuch, A., Wozniak-Kosek, A., Korzeniewski, K., Zycinska, K., Wardyn, K., Brydak, L.B. (2013). Clinical Features and Outcomes of Influenza A and B Infections in Children. In: Pokorski, M. (eds) Neurobiology of Respiration. Advances in Experimental Medicine and Biology, vol 788. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6627-3_14
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