Abstract
The Myc family proteins are key regulators of animal growth and development, which have critical roles in modulating stem cell behaviour. Since the identification of the oncogenic potential of c-Myc in the early 1980s the mammalian Myc family, which is comprised of c-Myc, N-Myc, and L-Myc, has been studied extensively. dMyc, the only Drosophila member of the Myc gene family, is orthologous to the mammalian c-Myc oncoprotein. Here we discuss key studies addressing the function of the Myc family in stem cell behaviour in both Drosophila Models and mammalian systems.
Keywords
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Acknowledgements
Thanks to Bob Eisenman and David Stein for the dMyc antibodies and to the Vienna Drosophila Research Centre (VDRC) for the dMyc RNAi lines. This work was supported by grants from the National Health and Medical Research Council (NHMRC).
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Quinn, L.M., Secombe, J., Hime, G.R. (2013). Myc in Stem Cell Behaviour: Insights from Drosophila . In: Hime, G., Abud, H. (eds) Transcriptional and Translational Regulation of Stem Cells. Advances in Experimental Medicine and Biology, vol 786. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6621-1_15
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