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Regulation of Intestinal Stem Cells by Wnt and Notch Signalling

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Transcriptional and Translational Regulation of Stem Cells

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 786))

Abstract

The mammalian intestine is lined by an epithelial cell layer that is constantly renewed via a population of stem cells that reside in a specialised niche within intestinal crypts. The recent development of tools that permit genetic manipulation and lineage tracing of cells in vivo combined with culture methods in vitro has made the intestine particularly amenable for the study of signals that regulate stem cell function. Both Wnt and Notch signalling are critical regulators of stem cell fate. Gene knockout and transgenic expression analysis combined with meticulous analysis of lineage tracing and molecular characterisation has contributed to the definition of the mechanisms by which these pathways act during normal homeostasis and in disease states.

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Authors and Affiliations

  1. Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC, 3800, Australia

    Katja Horvay & Helen E. Abud

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  1. Katja Horvay
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  2. Helen E. Abud
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Correspondence to Helen E. Abud .

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Editors and Affiliations

  1. , Anatomy and Neuroscience, University of Melbourne, VIC Grattan Street, Parkville, 3010, Victoria, Australia

    Gary Hime

  2. , Anatomy and Developmental Biology, Monash University, Monash University, Clayton, 3800, Victoria, Australia

    Helen Abud

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Horvay, K., Abud, H.E. (2013). Regulation of Intestinal Stem Cells by Wnt and Notch Signalling. In: Hime, G., Abud, H. (eds) Transcriptional and Translational Regulation of Stem Cells. Advances in Experimental Medicine and Biology, vol 786. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6621-1_10

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