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Epigenetics and Cancer pp 85–94Cite as

Epigenetic Regulation of MicroRNA in Colon Cancer

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Abstract

Colorectal cancer (CRC) is the leading cause of death from cancer all over the world. New and improved approaches are needed to detect CRC early and develop effective therapeutic approaches. Recently, the role of non-coding small microRNAs (miRs) in CRC initiation and progression has been proposed. In this article, we have summarized which miRs are commonly regulated by epigenetic mechanisms in CRC and their contribution towards gene regulation leading to carcinogenesis. The potential implications of using miR as a marker of risk, therapeutic target and survival are discussed. Future studies should emphasize translational research including the validation of key findings from different laboratories and investigators and the implications of these findings for clinical practice.

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Author information

Authors and Affiliations

  1. Harry S. Truman Memorial Veterans’ Hospital, Columbia, MO, 65201, USA

    Qiong Zhang & Sharad Khare Ph.D.

  2. Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Missouri, CE440 Clinical and Educational Support Building, One Hospital Drive, Columbia, MO, 65212, USA

    Qiong Zhang & Sharad Khare Ph.D.

  3. Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA

    Mukesh Verma

Authors
  1. Qiong Zhang
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  2. Mukesh Verma
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  3. Sharad Khare Ph.D.
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Corresponding author

Correspondence to Sharad Khare Ph.D. .

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Editors and Affiliations

  1. Barbara Ann Karmanos Cancer Institute, Dept. of Pathology, School of Medicine, Wayne State University, John R 4100, Detroit, 48201, Michigan, USA

    Fazlul H. Sarkar

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Zhang, Q., Verma, M., Khare, S. (2013). Epigenetic Regulation of MicroRNA in Colon Cancer. In: Sarkar, F. (eds) Epigenetics and Cancer. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6612-9_5

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