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Regulation of Neuroblastoma Cell Differentiation by Retinoic Acid: Role of Alternative Splicing and micro-RNAs

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Pediatric Cancer, Volume 4

Part of the book series: Pediatric Cancer ((PECA,volume 4))

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Abstract

High-risk metastatic neuroblastoma tumors have a poor prognosis even after aggressive multimodal therapeutic protocols. Retinoic Acid (RA) treatments were included in these multimodal therapies because its ability to induce differentiation of neuroblastoma cells in vitro and it appears to reduce the risk of tumor recurrence as established in a large multicentre clinical assay. The present article deals with the molecular actions of RA on neuroblastoma cells. We want to discuss novel actions of RA at the post-transcriptional level (alternative splicing, translational control of specific mRNAs, microRNA regulation) that in addition to the well-characterized actions of RA at the transcriptional level contribute to neuroblastoma cell differentiation. We propose that RA acts coordinately over the multiple regulatory layers of gene expression and therefore must be considered as a global regulator of gene expression in neuroblastoma cells.

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Acknowledgements

The research work described in this article was financed through grants of the Spanish National Plan for Research, Development and Innovation (SAF2003-00311, SAF2006-00647, SAF2007-60780, and SAF2010-15032), Generalitat Valenciana (ACOMP 09/212) and Genoma España to D. Barettino. S. Meseguer was the recipient of an EACR training and travel fellowship award and a CSIC I3P predoctoral fellowship/contract. E. J. Laserna was the recipient of a pre-doctoral fellowship/contract (FPI) from Consellería de Educación y Ciencia de la Generalitat Valenciana (Spain). S. Masiá was supported by a pre-doctoral fellowship (FPI) from the former Ministry of Science and Technology and a contract from Programa de Contratación de Técnicos, former Ministry of Education and Science.

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  1. CSIC-Institute of Biomedicine of Valencia, C/ JaimeRoig, 11, 46010, Valencia, Spain

    Salvador Meseguer, Emilio J. Laserna, Juan Manuel Escamilla, Susana Masiá & Domingo Barettino

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  1. Salvador Meseguer
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  2. Emilio J. Laserna
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  3. Juan Manuel Escamilla
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  4. Susana Masiá
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  5. Domingo Barettino
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Correspondence to Domingo Barettino .

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    M.A. Hayat

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Meseguer, S., Laserna, E.J., Escamilla, J.M., Masiá, S., Barettino, D. (2013). Regulation of Neuroblastoma Cell Differentiation by Retinoic Acid: Role of Alternative Splicing and micro-RNAs. In: Hayat, M. (eds) Pediatric Cancer, Volume 4. Pediatric Cancer, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6591-7_5

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