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Ewing’s Sarcoma: Current Concepts in Chemotherapy and Surgical Control

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Pediatric Cancer, Volume 4

Part of the book series: Pediatric Cancer ((PECA,volume 4))

Abstract

Ewing sarcoma is a relatively rare tumor of childhood and constitutes 3% of all pediatric malignancies. It is pathologically a malignant round cell tumor, CD99 positive on immunohistochemical staining and characterized by a unique translocation, t(11;22). The most common presenting symptoms are persistent pain and swelling. Imaging of primary site and biopsy are essential for confirmation of diagnosis and staging work-up includes bone marrow biopsy, bone scan and CT scan of chest. A comprehensive multidisciplinary approach incorporating multiagent chemotherapy along with surgery and or radiation therapy is the standard of care. Outcome of patients with localized disease has improved considerably but remains dismal for those with metastatic and recurrent disease.

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Authors and Affiliations

  1. Pediatric Hematology Oncology, Rajiv Gandhi Cancer Institute and Research Center, Sec -V, Rohini, Delhi, 110085, India

    Gauri Kapoor & Sandeep Jain

  2. Orthopedic Oncosurgery, Rajiv Gandhi Cancer Institute and Research Center, Sec -V, Rohini, Delhi, 110085, India

    Akshay Tiwari

Authors
  1. Gauri Kapoor
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  2. Sandeep Jain
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  3. Akshay Tiwari
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Correspondence to Gauri Kapoor .

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Editors and Affiliations

  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

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Kapoor, G., Jain, S., Tiwari, A. (2013). Ewing’s Sarcoma: Current Concepts in Chemotherapy and Surgical Control. In: Hayat, M. (eds) Pediatric Cancer, Volume 4. Pediatric Cancer, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6591-7_22

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