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Pediatric Cancer, Volume 4 pp 155–165Cite as

Pediatric Lymphoma Patients: Cytomegalovirus Infection

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Part of the book series: Pediatric Cancer ((PECA,volume 4))

Abstract

Cancer care has improved and intensified over recent decades, and as patients with cancer survive longer, various infectious complications have been more pronounced. Pediatric cancer patients are at high risk of infectious complications because they are immunologically immature. Human cytomegalovirus (HCMV) is a persistent pathogen, can cause life threatening infection in immunocompromised patients, such as bone marrow and organ transplant recipients, ­persons with AIDS, and patients with hematological malignancies (leukemias and ­lymphomas). Despite Previous studies before application of sensitive molecular methods, demonstrated association of CMV with fever and hepatitis in children with malignancy, CMV has not been extensively studied in pediatric cancer patients. Very limited data are available in the literatures related to symptomatic CMV infection and its clinical relevance on outcome of diseases in pediatric cancer patients especially children with hematological malignancies. These studies are relevant as new advanced diagnostic techniques are now available for detection of the virus in different clinical specimens, ­new advances in the management of CMV infection and disease have been developed, and the performance of prospective clinical trails of antiviral agents has been evaluated. Therefore, the aim of this review is to shade a light on some of these data that are available in the literatures, and relevance of future studies concerned activity of CMV in pediatric lymphoma patients.

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Authors and Affiliations

  1. Virology and Immunology, Cancer Biology Department, National Cancer Institute, Cairo University, Giza, Egypt

    Samah A. Loutfy

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  1. Samah A. Loutfy
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Correspondence to Samah A. Loutfy .

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  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

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Loutfy, S.A. (2013). Pediatric Lymphoma Patients: Cytomegalovirus Infection. In: Hayat, M. (eds) Pediatric Cancer, Volume 4. Pediatric Cancer, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6591-7_15

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