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Clinical Management of Familial Gastric Cancer

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Spotlight on Familial and Hereditary Gastric Cancer

Abstract

The clinical management of familial gastric carcinoma requires a multidisciplinary counsel. In this chapter we discuss about the hereditary diffuse gastric cancer surveillance and other minor genetic diseases as the hereditary nonpolyposis colorectal cancer, Li-Fraumeni syndrome, and Peutz-Jeghers syndrome. Moreover we proposed an algorithm for the clinical management of familial intestinal gastric tumors, in which genetic test is not applicable.

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Abbreviations

DGC:

Diffuse Gastric Cancer

E-cad:

E-cadherin

EOGC:

Early Onset Gastric Cancer

FIGC:

Familial Intestinal Gastric Cancer

GC:

Gastric Cancer

HDGC:

Hereditary Diffuse Gastric Cancer

HNPCC:

Hereditary Non-Polyposis Colorectal Cancer

IGCLC:

International Gastric Cancer Linkage Consortium

LF:

Li-Fraumeni

MMR:

Mismatch Repair

MSI:

Microsatellite Instability

PJS:

Peutz-Jeghers Syndrome

XRCC1 :

X-Ray Cross Complementing Group 1

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Author information

Authors and Affiliations

  1. Section of General Surgery and Surgical Oncology, Department of Medical, Surgical Sciences and Neuroscience, University of Siena, Viale Bracci, Siena, 53100, Italy

    Giovanni Corso M.D., Ph.D., Daniele Marrelli M.D. & Franco Roviello M.D.

Authors
  1. Giovanni Corso M.D., Ph.D.
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  2. Daniele Marrelli M.D.
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  3. Franco Roviello M.D.
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Corresponding author

Correspondence to Giovanni Corso M.D., Ph.D. .

Editor information

Editors and Affiliations

  1. Dept. of Medical, Surgical Sciences, and Neurosciences, University of Siena, viale Bracci, Siena, 53100, Italy

    Giovanni Corso

  2. Dept. of Medical, Surgical Sciences, and Neurosciences, University of Siena, Via Banchi di Sotto 55, Siena, 53100, Italy

    Franco Roviello

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Corso, G., Marrelli, D., Roviello, F. (2013). Clinical Management of Familial Gastric Cancer. In: Corso, G., Roviello, F. (eds) Spotlight on Familial and Hereditary Gastric Cancer. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6570-2_16

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