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Gastric Cancer in Other Inherited Syndromes

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Spotlight on Familial and Hereditary Gastric Cancer

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Abstract

CDH1 germline mutation is the most important genetic mechanism that associates with the development of the hereditary diffuse gastric cancer syndrome. However, gastric carcinoma participates also in other inherited predispositions as the hereditary nonpolyposis colorectal cancer, Li-Fraumeni and Peutz Jeghers syndromes. While in these cases the gastric cancer risk is undefined and causative germline mutations are rarely identified, members of the family can be similarly tested and identified, providing targeted surveillance and management opportunities.

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Abbreviations

HDGC:

Hereditary Diffuse Gastric Cancer

HNPCC:

Hereditary Non-Polyposis Colorectal Cancer

LF:

Li Fraumeni

PJS:

Peutz-Jeghers Syndrome

MMR:

Mismatch Repair

MSI:

Microsatellite Instability

LFL:

Li–Fraumeni-like

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Author information

Authors and Affiliations

  1. Section of General Surgery and Surgical Oncology, Department of Medical, Surgical Sciences and Neuroscience, University of Siena, Viale Bracci, Siena, 53100, Italy

    Giovanni Corso M.D., Ph.D.

  2. Department of Cancer Genetics, Molecular Pathology Unit, Center for Cancer Research and Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA

    Sérgia Velho M.D.

  3. Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Rua Dr Roberto Frias S/N, Porto, 4200-465, Portugal

    Sérgia Velho M.D.

Authors
  1. Giovanni Corso M.D., Ph.D.
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  2. Sérgia Velho M.D.
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Corresponding author

Correspondence to Giovanni Corso M.D., Ph.D. .

Editor information

Editors and Affiliations

  1. Dept. of Medical, Surgical Sciences, and Neurosciences, University of Siena, viale Bracci, Siena, 53100, Italy

    Giovanni Corso

  2. Dept. of Medical, Surgical Sciences, and Neurosciences, University of Siena, Via Banchi di Sotto 55, Siena, 53100, Italy

    Franco Roviello

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Corso, G., Velho, S. (2013). Gastric Cancer in Other Inherited Syndromes. In: Corso, G., Roviello, F. (eds) Spotlight on Familial and Hereditary Gastric Cancer. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6570-2_15

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