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Advanced Bioactive Compounds Countering the Effects of Radiological, Chemical and Biological Agents pp 101–112Cite as

Cerium Oxide Nanoparticles Counteract the Oxidative Stress in Cardiac Progenitor Cells

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Abstract

Cardiac progenitor cells (CPCs) are a promising source of cells for cardiac regenerative medicine. However, the poor results obtained after a decade of intensive investigation have suggested that innovative protocols must be setup to preserve progenitor cell regenerative potential during the expansion procedure in vitro. Indeed, CPC culture in vitro requires the presence of micro-environmental conditions closely mimicking the natural cell surrounding in vivo. The capability of this micro-environment to uphold reactive oxygen species (ROS) within physiological levels in vitro is a major requisite. Cerium oxide nanoparticles (nanoceria) are redox-active and could represent a potent tool to control the oxidative stress in isolated CPCs. The exposure to 5, 10 and 50 μg/mL of nanoceria for 24 h does not affect cell survival and function in cardiac progenitor cells, while being able to protect CPCs from H2O2-induced cytotoxicity. All the tested concentrations have been effective in protecting CPCs from the oxidative stress in the long run and no evidence of toxic effects was detectable, indicating that nanoceria is an effective antioxidant. Therefore, these findings confirm the great potential of nanoceria for controlling ROS-induced cell damage.

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Authors and Affiliations

  1. Laboratorio di Cardiologia Molecolare e Cellulare, Dipartimento di Medicina Interna, Università di Roma Tor Vergata, Via Montpellier, 1, Rome, 00133, Italy

    Francesca Pagliari & Paolo Di Nardo

  2. BioLink Institute, Link Campus University, 00198, Rome, Italy

    Francesca Pagliari & Paolo Di Nardo

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  1. Francesca Pagliari
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  2. Paolo Di Nardo
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Correspondence to Paolo Di Nardo .

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Editors and Affiliations

  1. St. Boniface Hospital Research Centre, Tache Ave 351, Winnipeg, R2H 2A6, Canada

    Grant N. Pierce

  2. , Division of Health and Rehabilitation, Crimean State Humanitarian University, Sevastopolskaya St. 2, Yalta, Crimea, 98635, Ukraine

    Volodymyr I. Mizin

  3. St. Boniface Hospital Research Centre, Tache Avenue 351, Winnipeg, R2H 2A6, Manitoba, Canada

    Alexander Omelchenko

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Pagliari, F., Di Nardo, P. (2013). Cerium Oxide Nanoparticles Counteract the Oxidative Stress in Cardiac Progenitor Cells. In: Pierce, G., Mizin, V., Omelchenko, A. (eds) Advanced Bioactive Compounds Countering the Effects of Radiological, Chemical and Biological Agents. NATO Science for Peace and Security Series A: Chemistry and Biology. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6513-9_8

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