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Mitochondrial BKCa Channel as a Target for Cardioprotection

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Advanced Bioactive Compounds Countering the Effects of Radiological, Chemical and Biological Agents

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Abstract

Large-conductance Ca2+-activated K+ channels (BKCa) are widely expressed in the plasma membrane of various types of cells and play important roles in many physiological processes by providing negative feedback for membrane depolarization and Ca2+ entry. Their mitochondrial counterparts located in the inner membrane are thought to be involved in the control of mitochondrial functions and serve as mediators of cytoprotection. This review briefly outlines basic knowledge of the molecular structure, sources of tissue diversity, and modulation of BKCa channels by endogenous and pharmacological agents. Particular attention is paid to the heart with an emphasis on the role mitochondrial BKCa channels in various forms of cardioprotection against acute ischemia/reperfusion injury.

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Acknowledgments 

Supported by the Czech Science Foundation (grant 303/12/1162).

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Authors and Affiliations

  1. Department of Developmental Cardiology, Institute of Physiology, Academy of Sciences of the Czech Republic, Vídeňská 1083, 14220, Prague, Czech Republic

    František Kolář

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  1. František Kolář
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Correspondence to František Kolář .

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Editors and Affiliations

  1. St. Boniface Hospital Research Centre, Tache Ave 351, Winnipeg, R2H 2A6, Canada

    Grant N. Pierce

  2. , Division of Health and Rehabilitation, Crimean State Humanitarian University, Sevastopolskaya St. 2, Yalta, Crimea, 98635, Ukraine

    Volodymyr I. Mizin

  3. St. Boniface Hospital Research Centre, Tache Avenue 351, Winnipeg, R2H 2A6, Manitoba, Canada

    Alexander Omelchenko

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Kolář, F. (2013). Mitochondrial BKCa Channel as a Target for Cardioprotection. In: Pierce, G., Mizin, V., Omelchenko, A. (eds) Advanced Bioactive Compounds Countering the Effects of Radiological, Chemical and Biological Agents. NATO Science for Peace and Security Series A: Chemistry and Biology. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6513-9_13

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