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Magnetic and Mössbauer studies of fucan-coated magnetite nanoparticles for application on antitumoral activity

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LACAME 2012

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Abstract

Fucan-coated magnetite (Fe3O4) nanoparticles were synthesized by the coprecipitation method and studied by Mössbauer spectroscopy and magnetic measurements. The sizes of the nanoparticles were 8–9 nm. Magnetization measurements and Mössbauer spectroscopy at 300 K revealed superparamagnetic behavior. The magnetic moment of the Fe3O4 is partly screened by the Fucan coating aggregation. When the magnetite nanoparticles are capped with oleic acid or fucan, reduced particle-particle interaction is observed by Mössbauer and TEM studies. The antitumoral activity of the fucan-coated nanoparticles were tested in Sarcoma 180, showing an effective reduction of the tumor size.

Proceedings of the Thirteenth Latin American Conference on the Applications of the Mössbauer Effect, (LACAME 2012), Medellín, Columbia, 11–16 November 2012.

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Author information

Authors and Affiliations

  1. Programa de Pós-Graduação em Ciências de Materiais, CCEN, Universidade Federal de Pernambuco, Av. Prof. Moraes Rego s/n, Cidade Universitária, Recife, PE, CEP 50670-901, Brazil

    V. A. J. Silva, P. L. Andrade & J. Albino Aguiar

  2. Laboratório de Imunopatologia Keizo Asami (LIKA), Departamento de Bioquímica, Universidade Federal de Pernambuco, Av. Prof. Moraes Rego s/n, Cidade Universitária, Recife, PE, CEP 50670-901, Brazil

    V. A. J. Silva, P. L. Andrade & M. P. C. Silva

  3. Laboratorio de Cerámicos y Nanomateriales, Facultad de Ciencias Físicas, Universidad Nacional Mayor de San Marcos, 14-0149, Lima, Peru

    Angel Bustamante & M. Mejia

  4. Departamento de Física, Universidade Federal de Pernambuco, Av. Prof. Moraes Rego s/n, Cidade Universitária, Recife, PE, CEP 50670-901, Brazil

    L. de los Santos Valladares & J. Albino Aguiar

  5. Cavendish Laboratory, Department of Physics, University of Cambridge, J.J. Thomson Avenue, Cambridge, CB3 0HE, UK

    L. de los Santos Valladares

  6. Departamento de Antibióticos, Universidade Federal de Pernambuco, Av. Prof. Moraes Rego s/n, Cidade Universitária, Recife, PE, CEP 50670-901, Brazil

    I. A. Souza

  7. Hospital das Clínicas, Universidade Federal de Pernambuco, Av. Prof. Moraes Rego s/n, Cidade Universitária, Recife, PE, CEP 50670-901, Brazil

    K. P. S. Cavalcanti

Authors
  1. V. A. J. Silva
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  2. P. L. Andrade
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  3. Angel Bustamante
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  4. L. de los Santos Valladares
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  5. M. Mejia
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  6. I. A. Souza
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  7. K. P. S. Cavalcanti
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  8. M. P. C. Silva
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  9. J. Albino Aguiar
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Corresponding author

Correspondence to V. A. J. Silva .

Editor information

Editors and Affiliations

  1. Instituto de Física, Universidad de Antioquia, Medellín, Colombia

    C. A. Barrero Meneses

  2. Centro de Ciências Exatas Departamento de Física, Universidade Federal do Espírito Santo, Vitória, ES, Brazil

    E. Passamani Caetano

  3. Departamento de Física y Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina

    C. E. Rodríguez Torres

  4. Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago, Chile

    C. Pizarro

  5. Departamento de Física, Universidad del Valle, Cali, Colombia

    L. E. Zamora Alfonso

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Silva, V.A.J. et al. (2013). Magnetic and Mössbauer studies of fucan-coated magnetite nanoparticles for application on antitumoral activity. In: Meneses, C.A.B., Caetano, E.P., Torres, C.E.R., Pizarro, C., Alfonso, L.E.Z. (eds) LACAME 2012. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6482-8_26

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