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Protein Interaction Partners of Cav2.3 R-Type Voltage-Gated Calcium Channels

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Modulation of Presynaptic Calcium Channels

Abstract

The Cav2.3 voltage-gated calcium channel represents the most enigmatic of all voltage-gated calcium channels due to its pharmacological inertness and to its mixed characteristics of HVA and LVA calcium channels. Protein interaction partners of the cytosolic II-III linker of Cav2.3 contribute to calcium homeostasis by regulating the channels surface expression and activation. Specific regulation of Cav2.3 by proteins interacting with the carboxy terminal region plays an important role in exocytosis and presynaptic plasticity, linking channel function to long-term potentiation. Modulation of Cav2.3 by its interaction partners thus contributes to several physiologic processes such as signal transduction in the retina, insulin secretion and generation of rhythmic activity in the heart and in the brain.

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Abbreviations

APP:

Amyloid precursor protein

APLP1:

Amyloid precursor-like protein 1

CaM:

Calmodulin

CDF:

Calcium-dependent facilitation

CDI:

Calcium-dependent inactivation

DHP:

Dihydropyridines

EGFR:

Epidermal growth factor receptor

HVA:

High-voltage activated

LVA:

Low-voltage activated

PKC:

Protein kinase C

V-ATPase:

Vacuolar ATPase

VGCC:

Voltage-gated calcium channel

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  1. Institute for Neurophysiology, University of Cologne, Robert-Koch-Str. 39, Köln, D-50931, Germany

    Maxine Dibué, Etienne E. Tevoufouet, Felix Neumaier, Andreas Krieger, Alexandra Kiel, Dimitar Evdokimov, Thomas Galetin, Serdar Alpdogan, Isha Akhtar, Sabrina Scharf, Renate Clemens, Kayalvizhi Radhakrishnan, Jürgen Hescheler, Toni Schneider & Marcel A. Kamp

  2. Center for Molecular Medicine Cologne (CMMC), University of Cologne, Köln, Germany

    Maxine Dibué

  3. Department of Neurosurgery, University Hospital, Heinrich-Heine-University, Düsseldorf, Moorenstraße 5, D-40225, Germany

    Maxine Dibué & Marcel A. Kamp

  4. Baylor College of Medicine, Houston, TX, USA

    Kayalvizhi Radhakrishnan

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    Gary Stephens

  2. , Department of Physiology, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo, 160-8402, Japan

    Sumiko Mochida

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Dibué, M. et al. (2013). Protein Interaction Partners of Cav2.3 R-Type Voltage-Gated Calcium Channels. In: Stephens, G., Mochida, S. (eds) Modulation of Presynaptic Calcium Channels. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6334-0_7

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