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Splicing and Editing to Customize CaV Channel Structures for Optimal Neural Function

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Modulation of Presynaptic Calcium Channels

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Abstract

Post-transcriptional modification (PTM) including mechanisms such as alternative splicing and A-to-I RNA editing are powerful and versatile mechanisms that greatly expand the coding potential of the genome, giving rise to a more diverse transcriptome and subsequently a larger proteome. While alternative splicing relies on combinatorial assembly of alternative exons, A-to-I RNA enables pin-point recoding of specific single nucleotides in the transcripts. The primary transcripts of neuronal CaV channels undergo extensive alternative splicing, but a restricted A-to-I RNA editing, often in a tissue specific manner to generate distinct channel isoforms that could be optimally customized for different aspects of neuronal activities. Here, we discuss the functional relevance of alternative splicing and RNA editing of CaV channels focusing on L-type CaV1.2 and CaV1.3, P/Q-type CaV2.1, N-type CaV2.2 and R-type CaV2.3 channels.

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Authors and Affiliations

  1. Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, MD9, 2 Medical Drive, 117597, Singapore, Singapore

    Hua Huang & Tuck Wah Soong

  2. Department of Physiology, Nanjing Medical University, Nanjing, China

    Juejin Wang

  3. NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore, Singapore

    Tuck Wah Soong

  4. Neurobiology/Ageing Programme, National University of Singapore, Singapore, Singapore

    Tuck Wah Soong

  5. National Neuroscience Institute, 308433, Singapore, Singapore

    Tuck Wah Soong

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  1. , School of Pharmacy, University of Reading, Whiteknights, Hopkins Building, Reading, RG6 6UB, Berkshire, United Kingdom

    Gary Stephens

  2. , Department of Physiology, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo, 160-8402, Japan

    Sumiko Mochida

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Huang, H., Wang, J., Soong, T.W. (2013). Splicing and Editing to Customize CaV Channel Structures for Optimal Neural Function. In: Stephens, G., Mochida, S. (eds) Modulation of Presynaptic Calcium Channels. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6334-0_13

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