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Phosphatidic Acid-Mediated Signaling

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Lipid-mediated Protein Signaling

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 991))

Abstract

Phosphatidic acid (PA) is recognized as an important class of lipid messengers. The cellular PA levels are dynamic; PA is produced and metabolized by several enzymatic reactions, including different phospholipases, lipid kinases, and phosphatases. PA interacts with various proteins and the interactions may modulate enzyme catalytic activities and/or tether proteins to membranes. The PA-protein interactions are impacted by changes in cellular pH and other effectors, such as cations. PA is involved in a wide range of cellular processes, including vesicular trafficking, cytoskeletal organization, secretion, cell proliferation, and survival. Manipulations of different PA production reactions alter cellular and organismal response to a wide range of abiotic and biotic stresses. Further investigations of PA’s function and mechanisms of action will advance not only the understanding of cell signaling networks but also may lead to biotechnological and pharmacological applications.

Yu Liu and Yuan Su contributed equally

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Acknowledgements

The work resulting from Wang laboratory was supported by grants from the National Science Foundation Grant IOS-0818740, the US Dep­artment of Agriculture Grant 2007-35318-18393, and the US Department of Energy Grant DE-SC0001295. We thank Brian Fanella for critical reading of the manuscript.

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Authors and Affiliations

  1. Department of Biology, University of Missouri, St. Louis, MO, 63121, USA

    Yu Liu, Yuan Su & Xuemin Wang

  2. Donald Danforth Plant Science Center, St. Louis, MO, 63121, USA

    Yu Liu, Yuan Su & Xuemin Wang

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  1. Yu Liu
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  2. Yuan Su
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  3. Xuemin Wang
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Correspondence to Xuemin Wang .

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  1. , Biological Sciences, Virginia Tech, Kraft Drive 1981, Blacksburg, 24061, Virginia, USA

    Daniel G.S. Capelluto

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Liu, Y., Su, Y., Wang, X. (2013). Phosphatidic Acid-Mediated Signaling. In: Capelluto, D. (eds) Lipid-mediated Protein Signaling. Advances in Experimental Medicine and Biology, vol 991. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6331-9_9

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