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Role of Phosphatidylinositol 3,4,5-Trisphosphate in Cell Signaling

  • Robert D. Riehle
  • Sinziana Cornea
  • Alexei DegterevEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 991)

Abstract

Many lipids present in cellular membranes are phosphorylated as part of signaling cascades and participate in the recruitment, localization, and activation of downstream protein effectors. Phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5)P3) is one of the most important second messengers and is capable of interacting with a variety of proteins through specific PtdIns(3,4,5)P3 binding domains. Localization and activation of these effector proteins controls a myriad of cellular functions including cell survival, proliferation, cytoskeletal rearrangement, and gene expression. Aberrations in the production and metabolism of PtdIns(3,4,5)P3 have been implicated in many human diseases including cancer, diabetes, inflammation, and heart disease. This chapter provides an overview of the role of PtdIns(3,4,5)P3 in cellular regulation and the implications of PtdIns(3,4,5)P3 dysregulation in human diseases. Additionally, recent attempts at targeting PtdIns(3,4,5)P3 signaling via small molecule inhibitors are summarized.

Keywords

Phosphatidylinositol (3,4,5)-trisphosphate PI3-kinase Akt PTEN Tumorigenesis 

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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Robert D. Riehle
    • 1
  • Sinziana Cornea
    • 2
  • Alexei Degterev
    • 2
    Email author
  1. 1.Department of Pharmaceutical Sciences, Center for Pharmaceutical Biotechnology and NanomedicineNortheastern UniversityBostonUSA
  2. 2.Department of BiochemistryTufts University School of MedicineBostonUSA

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