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Thyroid Cancer Stem Cells – Strategies for Therapeutic Targeting

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Stem Cells and Cancer Stem Cells, Volume 10

Part of the book series: Stem Cells and Cancer Stem Cells ((STEM,volume 10))

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Abstract

Thyroid cancer stem cells are capable of sustaining neoplastic growth. Because they are often resistant to chemotherapy and radiation therapy, they present a major obstacle to effective thyroid cancer treatment. This review discusses the recent discovery of cancer stem cells in many subtypes of thyroid cancer, including papillary, follicular, medullary and anaplastic. It emphasizes potential new therapeutic strategies targeting multi-drug resistance, DNA repair and oncogenic signaling pathways activated in the stem cells during cancer progression. These new, targeted therapies, if realized, may improve the efficacy of current therapeutic treatments against advanced thyroid cancer, prevent disease relapse and enhance patient survival.

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Acknowledgements

Work in the laboratory of R.Y.L. is supported by grants from National Institute of Health (NIH) R01DK068057, the Washington University Institute of Clinical and Translational Sciences grant UL1TR000448 from the National Center for Advancing Translational Sciences (NCATS) of NIH, and the President’s Research Fund of Saint Louis University.

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Authors and Affiliations

  1. Department of Internal Medicine Division of Endocrinology, Saint Louis University School of Medicine, Doisy Research Center, Room 225, 1100 South Grand Blvd, Saint Louis, MO, 63104, USA

    Reigh-Yi Lin, William Sewell, Kyle Spradling, Ashley N. Reeb & Wen Li

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  1. Reigh-Yi Lin
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  2. William Sewell
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  3. Kyle Spradling
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  4. Ashley N. Reeb
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  5. Wen Li
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Correspondence to Reigh-Yi Lin .

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  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

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Lin, RY., Sewell, W., Spradling, K., Reeb, A.N., Li, W. (2013). Thyroid Cancer Stem Cells – Strategies for Therapeutic Targeting. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 10. Stem Cells and Cancer Stem Cells, vol 10. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6262-6_16

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