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Generation of Antigen-Specific T Lymphocytes from Induced Pluripotent Stem Cells for Adoptive Immunotherapy

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Stem Cells and Cancer Stem Cells, Volume 10

Part of the book series: Stem Cells and Cancer Stem Cells ((STEM,volume 10))

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Abstract

Conquering cancer, one of the leading human health problems, is a major task for both basic and clinical scientists. With the understanding of recently developed cancer immunotherapy, in particular the cytotoxic T lymphocyte (CTL)-mediated immunotherapy, T cell development as well as the applications of stem cell technologies, an individualized cancer immunotherapy could be promisingly designed by avoiding several main obstacles in obtaining a large number of autologous and highly-reactive tumor-specific CTLs. Through induced pluripotent stem (iPS) cell technologies, tumor-specific CTLs could be generated from a piece of skin or blood from the individual cancer patient, following genetic modification as well as a directed differentiation. This novel approach could potentially further expand the weaponry to battle cancer.

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Acknowledgement

This project was funded, in part, under grants with the Grant Number K18CA151798 from the National Cancer Institute (NCI) and the Breast Cancer Alliance to J.S.

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Authors and Affiliations

  1. Microbiology & Immunology H107, Room C6749, Penn State University College of Medicine, 500 University Drive, Hershey, PA, 17033, USA

    Fengyang Lei, Rizwanul Haque, Xiaofang Xiong & Jianxun Song

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  1. Fengyang Lei
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  2. Rizwanul Haque
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  3. Xiaofang Xiong
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  4. Jianxun Song
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Corresponding author

Correspondence to Jianxun Song .

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  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

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Lei, F., Haque, R., Xiong, X., Song, J. (2013). Generation of Antigen-Specific T Lymphocytes from Induced Pluripotent Stem Cells for Adoptive Immunotherapy. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 10. Stem Cells and Cancer Stem Cells, vol 10. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6262-6_10

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