Abstract
Since the discovery that certain bone marrow cells are capable of ectopic bone formation in 1963, scientists scented new therapeutic strategies to overcome clinical problems of bone defects unable to heal or fuse spontaneously. Today, these cells are defined as Mesenchymal Stem Cells (MSCs) and beside bone marrow other tissues emerged as rich sources for this valuable cell type. Even if their role in endogenous bone regeneration is still under debate, exogenous supply already revealed promising results. Due to proper isolation, proliferation and differentiation into the osteogenic lineage, MSCs were capable for bona fide bone formation in vitro as well as in vivo. Nevertheless, obstacles remain, as clinical utilization of MSCs has not fulfilled the expectations based on animal studies yet. Application of MSCs has the theoretical potential to promote bone healing. Though, further investigations are required in order to implement transplantation of MSCs as a standard procedure in orthopedic and reconstructive surgery.
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We thank Stephan Winkelmann for his work on the figures.
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Fischer, S., Schulte, M., Hirsch, T., Lehnhardt, M., Behr, B. (2013). Mesenchymal Stem Cells in Bone Regeneration. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 10. Stem Cells and Cancer Stem Cells, vol 10. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6262-6_1
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DOI: https://doi.org/10.1007/978-94-007-6262-6_1
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