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The Tumor Immunoenvironment pp 107–133Cite as

Development of Antitumor Cellular Immunity

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Abstract

A dazzling picture of many different types of innate and adaptive immune cells that have infiltrated a patient’s tumor emerges when a tumor section is studied under the microscope. There is good evidence that patient survival depends on the numbers, type, character and localization of particular tumor-infiltrating immune cells, in particular T cells and macrophages. Here we discuss the events governing the arousal of a spontaneous tumor-specific T cell response and how the tumor-rejecting efficacy of this T cell response is regulated by the intratumoral cytokine milieu, the expression of inhibitory molecules and co-infiltrating immune cells. Finally, we describe approaches to change the local micromilieu so that the net outcome is a strong induction of an anti-tumor immune response coupled to a better infiltration of tumors under conditions that allows these immune cells to exert their function and to control tumor outgrowth.

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Authors and Affiliations

  1. Department of Clinical Oncology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands

    M. J. P. Welters & S. H. van der Burg

  2. Department of Clinical Oncology, Leiden University Medical Center, Building 1, K1-P, PO box 9600, 2300 RC, Leiden, The Netherlands

    S. H. van der Burg

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  1. M. J. P. Welters
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  2. S. H. van der Burg
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Correspondence to S. H. van der Burg .

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Editors and Affiliations

  1. Department of Pathology, University of Pittsburgh Medical Center, 3550 Terrace Street Scaife Hal, Pittsburgh, 15213, Pennsylvania, USA

    Michael R. Shurin

  2. , Clinical Cooperation Unit Dermato-Oncolo, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, 69120, Germany

    Viktor Umansky

  3. , SAIC-Frederick, Inc., National Cancer Institute at Frederick, Post Office B, Frederick, 21702, Maryland, USA

    Anatoli Malyguine

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Welters, M.J.P., van der Burg, S.H. (2013). Development of Antitumor Cellular Immunity. In: Shurin, M., Umansky, V., Malyguine, A. (eds) The Tumor Immunoenvironment. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6217-6_5

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