Abstract
Silkworm is economically important and also has a large number of activities encompassing anticancer, antibacterial, antibacterial, antiviral, antihypertensive, angiotensin-converting enzyme activity, hepatoprotective, superoxide dismutase enzyme activity, free radical scavenging and tyrosinase inhibitory, antidiabetic, antityrosinase, cognition enhancing, alternative complement pathway-inhibiting, carotenoid binding, chymotrypsin inhibiting, and chitinase activities. These activities may be beneficial to human health.
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References
Omenetto FG, Kaplan DL (2010) New opportunities for an ancient material. Science 329:528–531
Arunkumar KP, Metta M, Nagaraju J (2006) Molecular phylogeny of silkmoths reveals the origin of domesticated silkmoth, Bombyx mori from Chinese Bombyx mandarina and paternal inheritance of Antheraea proylei mitochondrial DNA. Mol Phylogenet Evol 40:419–427
Ohnishi A, Kaji M, Hashimoto K, Matsumoto S (2011) Screening for the genes involved in bombykol biosynthesis: identification and functional characterization of Bombyx mori Acyl carrier protein. Front Endocrinol 2:92
Goldsmith MR, Shimada T, Abe H (2005) The genetics and genomics of the silkworm, Bombyx mori. Annu Rev Entomol 50:71–100
Hu D, Liu Q, Cui H, Wang H, Han D, Xu H (2005) Effects of amino acids from selenium-rich silkworm pupas on human hepatoma cells. Life Sci 77:2098–2110
Lockey TD, Ourth DD (1996) Purification and characterization of lysozyme from hemolymph of Heliothis virescens larvae. Biochem Biophys Res Commun 220:502–508
Taniai K, Kato Y, Hirochika H, Yamakawa M (1992) Isolation and nucleotide sequence of cecropin B cDNA clones from the silkworm, Bombyx mori. Biochim et Biophys Acta 1132:203–206
Yu KH, Kim KN, Lee JH, Lee HS, Kim SH, Cho KY et al (2002) Comparative study on characteristics of lysozymes from the hemolymph of three lepidopteran larvae, Galleria mellonella, Bombyx mori, Agrius convolvuli. Dev Comp Immun 26:707–713
Powning RF, Davidson WJ (1973) Studies on insect bacteriolytic enzymes. I. Lysozyme in haemolymph of Galleria mellonella and Bombyx mori. Comp Biochem Physiol B: Comp Biochem 45:669–686
Gandhe AS, Janardhan G, Nagaraju J (2007) Immune upregulation of novel antibacterial proteins from silkmoths (Lepidoptera) that resemble lysozymes but lack muramidase activity. Insect Biochem Mol Biol 37:655–666
Ng TB (2004) Antifungal proteins and peptides of leguminous and non-leguminous origins. Peptides 25:1215–1222
Abraham EG, Nagaraju J, Salunke D, Gupta HM, Datta RK (1995) Purification and partial characterization of an induced antibacterial protein in the silkworm, Bombyx mori. J Invertebr Pathol 65:17–24
Hara S, Yamakawa M (1995) A novel antibacterial peptide family isolated from the silkworm, Bombyx mori. Biochem J 310(Pt 2):651–656
Hara S, Yamakawa M (1995) Moricin, a novel type of antibacterial peptide isolated from the silkworm, Bombyx mori. The Journal of biological chemistry 270:29923–29927
Hara S, Yamakawa M (1996) Production in Escherichia of moricin, a novel type antibacterial peptide from the silkworm, Bombyx mori. Biochem Biophys Res Commun 220:664–669
Li BC, Zhang SQ, Dan WB, Chen YQ, Cao P (2007) Expression in Escherichia coli and purification of bioactive antibacterial peptide ABP-CM4 from the Chinese silk worm, Bombyx mori. Biotechnol Lett 29:1031–1036
Hiraki A, Yukawa M, Kim J, Ueda S (1997) Antiviral substance from silkworm faeces: purification and its chemical characterization. Biol Pharm Bull 20:547–555
Jacob JR, Mansfield K, You JE, Tennant BC, Kim YH (2007) Natural iminosugar derivatives of 1-deoxynojirimycin inhibit glycosylation of hepatitis viral envelope proteins. J Microbiol 45:431–440
Gotoh K, Izumi H, Kanamoto T, Tamada Y, Nakashima H (2000) Sulfated fibroin, a novel sulfated peptide derived from silk, inhibits human immunodeficiency virus replication in vitro. Biosci Biotechnol Biochem 64:1664–1670
Selot R, Kumar V, Shukla S, Chandrakuntal K, Brahmaraju M, Dandin SB et al (2007) Identification of a soluble NADPH oxidoreductase (BmNOX) with antiviral activities in the gut juice of Bombyx mori. Biosci Biotechnol Biochem 71:200–205
Masuyer G, Schwager SL, Sturrock ED, Isaac RE, Acharya KR (2012) Molecular recognition and regulation of human angiotensin-I converting enzyme (ACE) activity by natural inhibitory peptides. Sci Rep 2:717
Harrap SB, Davidson HR, Connor JM, Soubrier F, Corvol P, Fraser R et al (1993) The angiotensin I converting enzyme gene and predisposition to high blood pressure. Hypertension 21:455–460
Wang W, Shen S, Chen Q, Tanga B, He G, Ruan H et al (2008) Hydrolyzates of silkworm pupae (Bombyx mori) protein is a new source of angiotensin I-converting enzyme inhibitory peptides (ACEIP). Curr Pharm Biotechnol 9:307–314
Ni L, Tao GJ, Dai J, Wang Z, Xu SY (2001) Separation, purification and identification of angiotensin converting enzyme inhibitory silk fibroin peptide. Se Pu = Chin J Chromatogr/Zhongguo Hua Xue Hui 19:222–225
Zhou F, Xue Z, Wang J (2010) Antihypertensive effects of silk fibroin hydrolysate by alcalase and purification of an ACE inhibitory dipeptide. J Agric Food Chem 58:6735–6740
Quan GX, Mita K, Okano K, Shimada T, Ugajin N, Xia Z et al (2001) Isolation and expression of the ecdysteroid-inducible angiotensin-converting enzyme-related gene in wing discs of Bombyx mori. Insect Biochem Mol Biol 31:97–103
Raghavendra R, Neelagund S, Kuluvar G, Bhanuprakash V, Revanaiah Y (2010) Protective effect of partially purified 35 kDa protein from silk worm (Bombyx mori) fecal matter against carbon tetrachloride induced hepatotoxicity and in vitro anti-viral properties. Pharm Biol 48:1426–1431
Leiherer A, Mundlein A, Drexel H (2012) Phytochemicals and their impact on adipose tissue inflammation and diabetes. Vasc Pharmacol 58(1–2):3–20
Wang HY, Wang YJ, Zhou LX, Zhu L, Zhang YQ (2012) Isolation and bioactivities of a non-sericin component from cocoon shell silk sericin of the silkworm Bombyx mori. Food Function 3:150–158
Lee HJ, Lee HS, Choi JW, Ra KS, Kim JM, Suh HJ (2011) Novel tripeptides with alpha-glucosidase inhibitory activity isolated from silk cocoon hydrolysate. J Agric Food Chem 59:11522–11525
Kim K, Park S, Yoo HK, Lee JY, Jung HY, Kim DH et al (2009) Brain factor-7 extracted from Bombyx mori enhances cognition and attention in normal children. J Med Food 12:643–648
Fang EF, Ng TB (2011) Bitter gourd (Momordica charantia) is a cornucopia of health: a review of its credited antidiabetic, anti-HIV, and antitumor properties. Curr Mol Med 11:417–436
Manosroi A, Boonpisuttinant K, Winitchai S, Manosroi W, Manosroi J (2010) Free radical scavenging and tyrosinase inhibition activity of oils and sericin extracted from Thai native silkworms (Bombyx mori). Pharm Biol 48:855–860
Yamamoto K, Zhang P, Banno Y, Fujii H, Miake F, Kashige N et al (2005) Superoxide dismutase from the silkworm, Bombyx mori: sequence, distribution, and overexpression. Biosci Biotechnol Biochem 69:507–514
Stephan AH, Barres BA, Stevens B (2012) The complement system: an unexpected role in synaptic pruning during development and disease. Annu Rev Neurosci 35:369–389
Ji KM, Zhan ZK, Chen JJ, Liu ZG (2008) Anaphylactic shock caused by silkworm pupa consumption in China. Allergy 63:1407–1408
Liu Z, Xia L, Wu Y, Xia Q, Chen J, Roux KH (2009) Identification and characterization of an arginine kinase as a major allergen from silkworm (Bombyx mori) larvae. Int Arch Allergy Immunol 150:8–14
Zhao P, Xia Q, Li J, Fujii H, Banno Y, Xiang Z (2007) Purification, characterization and cloning of a chymotrypsin inhibitor (CI-9) from the hemolymph of the silkworm, Bombyx mori. Protein J 26:349–357
Fang EF, Hassanien AA, Wong JH, Bah CS, Soliman SS, Ng TB (2011) Isolation of a new trypsin inhibitor from the Faba bean (Vicia faba cv. Giza 843) with potential medicinal applications. Protein Pept Lett 18:64–72
Liu M, Zhang H, Hu X, Wei Q (2010) Purification and characterization of a chitinase from Bombyx mori. Sheng Wu Gong Cheng Xue Bao = Chin J Biotechnol 26:404–409
Aramwit P, Damrongsakkul S, Kanokpanont S, Srichana T (2010) Properties and antityrosinase activity of sericin from various extraction methods. Biotechnol Appl Biochem 55:91–98
Acknowledgments
The award of a research grant (81273275) to Lixin Xia from the National Science Foundation of China is gratefully acknowledged.
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Xia, L., Ng, T.B., Fang, E.F., Wong, J.H. (2013). Bioactive Constituents of the Silk Worm Bombyx mori . In: Fang, E., Ng, T. (eds) Antitumor Potential and other Emerging Medicinal Properties of Natural Compounds. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6214-5_22
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DOI: https://doi.org/10.1007/978-94-007-6214-5_22
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