Abstract
Calcium (Ca2+) is a ubiquitous second messenger involved in the regulation of many cellular activities. Importantly, both cytosolic and nuclear Ca2+ signals have essential roles in the progression through the cell cycle. Ca2+ signals in the these subcellular compartments are generated through the concerted action of several components of the Ca2+ signaling machinery that reside in the plasma membrane, cytosol, nuclear envelope membrane, or the nucleus. The versatility and specificity of Ca2+ signals is determined by their spatial and temporal patterns, and Ca2+ signals can be regulated independently of cytosolic Ca2+ signals. This review discusses the machinery involved in cytosolic and nuclear Ca2+ signal formation, as well as the different mechanisms through which these Ca2+ signals modulate the process of cell proliferation.
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Acknowledgments
We thank the Howard Hughes Medical Institute, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Fundação de Amparo à Pesquisa do Estado de Minas Gerais, Fundação de Amparo à Pesquisa do Estado de São Paulo, and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.
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Amaya, M.J., Goulart, V.A.M., Santos, A.K., Kihara, A.H., Guatimosim, S., Resende, R.R. (2013). Role of Calcium Signaling in Stem and Cancer Cell Proliferation . In: Resende, R., Ulrich, H. (eds) Trends in Stem Cell Proliferation and Cancer Research. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6211-4_5
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