Abstract
Embryonic stem cells are the basis of developing organisms. They posses self-renewal capacity and pluripotency to eventually generate every cell type of the mature body. In the course of development, organs arise through morphogenesis, including the differentiation of tissue progenitor cells into mature cells. Thorough analysis of the composition and the heterogeneity of organs revealed the presence of residual tissue progenitors, which retain the capacity to repopulate organs if necessary, e.g., because of injury. Hence, organs display a hierarchical structure very comparable to the initial structures in the developing embryo, however with a loss of potency. Similarly to healthy organs, tumors have hierarchical structures comprising tumor progenitors, which give rise to the tumor bulk (i.e., more “differentiated” tumor cells). Tumor progenitors are termed cancer stem cells (CSCs) or tumor-initiating cells. In this chapter, we discuss markers commonly used to discriminate CSCs from the tumor bulk and address their functions in the context of tumor development. The main focus is on the structure and function of CD44, CD133, epithelial cell adhesion molecule, CD24, CD166, CD47, leucine-rich-repeat-containing G-protein-coupled receptor 5, and aldehyde dehydrogenase 1 in CSCs. Importantly, the option of substantial plasticity of CSCs is addressed in the light of the functions of CSC markers and their expression pattern.
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Gires, O. (2013). Markers of Cancer Stem Cells and Their Functions. In: Resende, R., Ulrich, H. (eds) Trends in Stem Cell Proliferation and Cancer Research. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6211-4_20
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