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Trends in Stem Cell Proliferation and Cancer Research pp 339–358Cite as

Migration, Metastasis, and More: The Role of Chemokines in the Proliferation, Spreading, and Metastasis of Tumors

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Abstract

Chemokines are a family of small peptides (8–15 kDa) that were first discovered as cytokines with chemotactic properties. Subsequently, it became clear that chemokines have much broader functions in tissue development and homeostasis as well as in pathological responses, especially in inflammation and cancer. After providing a short overview of chemokines, their regulation, receptors, and signal transduction, we outlines their role in various steps of tumor progression, in particular with regard to tumor cells, tumor stem cells, the tumor microenvironment, tumor angiogenesis, and the spreading/metastasis of tumors. The focus is on CXC chemokines and selected tumor types, e.g., gliomas, melanomas, and breast cancer. In addition to the tumor-promoting functions of chemokines and their receptors in the different steps of cancerogenesis, their potential as diagnostic and therapeutic targets is discussed.

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Acknowledgment

We thank Clemens Franke for careful drawing of some figures.

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Authors and Affiliations

  1. Department of Anatomy, University of Kiel, Olshausenstraβe 40, 24098, Kiel, Germany

    Rolf Mentlein & Kirsten Hattermann

  2. Department of Neurosurgery, University Medical Center Schleswig-Holstein UKSH, Campus Kiel, 24105, Kiel, Germany

    Janka Held-Feindt

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  1. Rolf Mentlein
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  2. Kirsten Hattermann
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Correspondence to Rolf Mentlein .

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Editors and Affiliations

  1. Instituto de Ciências Biológicas, Departamento de Bioquímica, Universidade Federal de Minas Gerais, Belo Horizonte, São Paulo, Brazil

    Rodrigo R. Resende

  2. Depto. Bioquímica, Universidade de São Paulo Inst. Química, São Paulo, São Paulo, Brazil

    Henning Ulrich

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Mentlein, R., Hattermann, K., Held-Feindt, J. (2013). Migration, Metastasis, and More: The Role of Chemokines in the Proliferation, Spreading, and Metastasis of Tumors. In: Resende, R., Ulrich, H. (eds) Trends in Stem Cell Proliferation and Cancer Research. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6211-4_13

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