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Organisation of the Tetraspanin Web

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Book cover Tetraspanins

Part of the book series: Proteins and Cell Regulation ((PROR,volume 9))

Abstract

Tetraspanins are currently hypothesized to promote membrane compartmentalization, through their ability to organize a network of molecular interactions termed the tetraspanin web or tetraspanin-enriched microdomains. In this chapter we will describe how the discovery of this unique ability of tetraspanins to interact with one another and with many other surface proteins led to this concept, and will discuss the hierarchical organization of these structures. We will also show how tetraspanins modulate the function of the proteins they associate with, including the regulation of trafficking, ligand binding, signal transduction and enzymatic activities.

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Authors and Affiliations

  1. Inserm U1004, 14 Av Paul Vaillant Couturier, 94807, Villejuif Cedex, France

    Eric Rubinstein & Stéphanie Charrin

  2. Institut André Lwoff, University Paris-Sud, 14 Av Paul Vaillant Couturier, 94807, Villejuif Cedex, France

    Eric Rubinstein & Stéphanie Charrin

  3. School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, B15 2TT, UK

    Michael G. Tomlinson

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  1. Eric Rubinstein
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  2. Stéphanie Charrin
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  3. Michael G. Tomlinson
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Correspondence to Eric Rubinstein , Stéphanie Charrin or Michael G. Tomlinson .

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  1. , School of Cancer Sciences, University of Birmingham, Vincent Drive, Birmingham, B15 2TT, United Kingdom

    Fedor Berditchevski

  2. INSERM U1004, Av. Paul Vaillant Couturier 14, Villejuif, F-94807, France

    Eric Rubinstein

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Rubinstein, E., Charrin, S., Tomlinson, M.G. (2013). Organisation of the Tetraspanin Web. In: Berditchevski, F., Rubinstein, E. (eds) Tetraspanins. Proteins and Cell Regulation, vol 9. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6070-7_3

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