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Tight Junctions in Cancer Metastasis pp 149–167Cite as

Tight Junctions in Colorectal Cancer

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Part of the book series: Cancer Metastasis - Biology and Treatment ((CMBT,volume 19))

Abstract

The intestine plays a major role in the absorption of nutrients, water, and electrolytes during digestion and protects the inner organs from the external environment. One of the major characteristics of this organ is that, while maintaining its function, it undergoes constant renewal at a very high rate, with the entire intestine renewed every 5–7 days in humans. This process occurs without disrupting the epithelial barrier, thus guaranteeing that the separation between external (lumen) and internal compartments is maintained, and that cell polarity is preserved. Tight junctions (TJ) are among the multi-protein complexes that play an essential role in the maintenance of this epithelial barrier. A number of observations have been made that the structure of tight junctions can be disrupted from early stages of neoplastic development in the intestine, and alterations of tight junction protein expression and/or localization have been reported in epithelial cancers, which significantly impacts on early tumorigenesis as well as tumor progression. In the present review, we summarize the current knowledge concerning alterations of tight junction protein expression in colorectal tumors, before discussing some of the likely consequences of these disruptions for tumorigenesis and the potential clinical use of tight junction proteins as prognostic markers or as targets for therapy in this type of tumors.

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Authors and Affiliations

  1. CNRS, UMR-5203, Institut de Génomique Fonctionnelle, Montpellier, F-34000, France

    Frédéric Hollande & Marina Papin

  2. INSERM, U661, Montpellier, F-34000, France

    Frédéric Hollande & Marina Papin

  3. Universités de Montpellier 1 & 2, UMR-5203, Montpellier, F-34000, France

    Frédéric Hollande & Marina Papin

  4. Department of Pathology, The University of Melbourne, Melbourne, Australia

    Marina Papin

Authors
  1. Frédéric Hollande
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  2. Marina Papin
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Corresponding author

Correspondence to Frédéric Hollande .

Editor information

Editors and Affiliations

  1. Cardiff University, Institute of Cancer & Genetics, Heath Park, Cardiff, CF14 4XN, West Glamorgan, United Kingdom

    Tracey A. Martin

  2. Cardiff University, Institute of Cancer & Genetics, Heath Park, Cardiff, CF4 4XN, United Kingdom

    Wen G. Jiang

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© 2013 Springer Science+Business Media Dordrecht

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Hollande, F., Papin, M. (2013). Tight Junctions in Colorectal Cancer. In: Martin, T., Jiang, W. (eds) Tight Junctions in Cancer Metastasis. Cancer Metastasis - Biology and Treatment, vol 19. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6028-8_7

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