Abstract
The majority of patients, who die from bladder cancer, ultimately do so from metastasis. A breakdown in the cell-cell bond seems likely to occur both, between cancer cells for tumour migration and between urothelial and endothelial cells for the development of metastases. Tight Junctions (TJ) exist between adjacent epithelial, endothelial and malignant cells and create a physiological barrier to the paracellular transport of solutes. They also contribute to cell polarity, regulate cell proliferation, and in addition are involved in cell signalling and cell-cell adhesion. Claudins are a group of trans-membrane proteins that contribute to TJ structure and function. Disruption of TJs with loss of TJ proteins, including claudins in cancer is thought to reduce cell-cell adhesion and contribute to invasion and metastasis. Altered expression of various claudins has been reported in several malignancies including bladder cancer, with an inverse correlation between the histological grade and the level of expression of some claudins. This review aims to explore the relationship between claudin expression and tumour progression in bladder cancer.
Keywords
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Learn about institutional subscriptionsAbbreviations
- AJ:
-
Adherens junctions
- CAR:
-
Coxsackieadenovirus receptor
- CPE:
-
Clostridium perfingens enterotoxin
- EGF:
-
Epithelial growth factor
- FAK:
-
Focal adhesion kinase
- GAG:
-
Glycosaminoglycan
- HGF:
-
Hepatocyte growth factor
- TCC:
-
Transitional cell carcinoma
- TJ:
-
Tight junction
- TUR:
-
Transurothelial resistance
- ZO:
-
Zonula occludens
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Martin, T.A., Haynes, M., Answare, N., Brown, G., Jiang, W.G. (2013). Tight Junctions in Human Urinary Bladder Cancer. In: Martin, T., Jiang, W. (eds) Tight Junctions in Cancer Metastasis. Cancer Metastasis - Biology and Treatment, vol 19. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6028-8_6
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