Abstract
The claudin family of proteins plays a critical role in the maintenance of epithelial and endothelial tight junctions, maintenance of the cytoskeleton and in cell signaling. While the exact functions of claudins in cancer cells are not fully understood, some studies suggest that claudins are involved in survival and invasion of cancer cells. Claudin-5, forming the backbone of tight junctions in blood vessels and lymphatic endothelial cells, has an important role in maintaining the homeostasis of the tissue microenvironment and tumors showing claudin-5 expression could have some additional affinity for blood vessels. Metastasis is a complex phenomenon that requires a number of specific steps such as decreased adhesion, increased motility and invasion, proteolysis, and resistance to apoptosis. Several studies about significance of claudin-5 expression in cancer cells were reported, suggesting that it may play an important role in regulation of metastasis, angiogenesis and tumor growth.
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Coutinho-Camillo, C.M., Lourenço, S.V., Soares, F.A. (2013). Claudin-5 and Cancer Metastasis. In: Martin, T., Jiang, W. (eds) Tight Junctions in Cancer Metastasis. Cancer Metastasis - Biology and Treatment, vol 19. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6028-8_11
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DOI: https://doi.org/10.1007/978-94-007-6028-8_11
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