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Biofabrication of Hydrogel Constructs

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Drug Delivery Systems: Advanced Technologies Potentially Applicable in Personalised Treatment

Part of the book series: Advances in Predictive, Preventive and Personalised Medicine ((APPPM,volume 4))

Abstract

Hydrogels are three dimensional (3D) hydrophilic networks with the ability to absorb and retain large amounts of water without dissolution, as a result of the establishment of physical or chemical bonds between the polymeric chains. Hydrogels obtained from either natural or synthetic polymers are attractive materials for tissue engineering applications due to their excellent biocompatibility, biodegradability, elasticity and compositional similarities to the extracellular matrix. Several techniques have been explored to produce hydrogel meshes, films or 3D constructs for cell attachment, differentiation and proliferation or to release drugs and growth factors according to specific release profiles. This chapter describes the current state-of-the-art of biomanufacturing additive processes to produce hydrogel constructs for tissue engineering. Biomanufacturing processes are described in detail and the major advantages and limitations outlined.

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Acknowledgements

This work was supported by the Portuguese Foundation for Science and Technology through the projects PTDC/EME-PME/098037/2008 and Pest-OE/EME/UI4044/2011.

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  1. Centre for Rapid and Sustainable Product Development, Polytechnic Institute of Leiria, Leiria, Portugal

    Rúben F. Pereira, Henrique A. Almeida & Paulo J. Bártolo

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  1. Rúben F. Pereira
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Correspondence to Paulo J. Bártolo .

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  1. , Chemical Engineering, University of Coimbra, Rua Silvio Lima, Coimbra, 3030 790, Portugal

    Jorge Coelho

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Pereira, R.F., Almeida, H.A., Bártolo, P.J. (2013). Biofabrication of Hydrogel Constructs. In: Coelho, J. (eds) Drug Delivery Systems: Advanced Technologies Potentially Applicable in Personalised Treatment. Advances in Predictive, Preventive and Personalised Medicine, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6010-3_8

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