Amphiphilic Molecules in Drug Delivery Systems

  • Salomé dos Santos
  • Bruno Medronho
  • Tiago dos Santos
  • Filipe E. AntunesEmail author
Part of the Advances in Predictive, Preventive and Personalised Medicine book series (APPPM, volume 4)


Numerous drug delivery colloidal systems are formulated using polymers or surfactants or a mixture of both, typically due to their self-assembly properties. Molecular self-assembly creates the possibility to dissolve and protect drugs from adverse external environments. Therefore, it is important to understand the interactions behind the self-assembly phenomena of surfactant and polymer molecules, polymer-polymer and polymer-surfactant mixtures. A number of colloidal structures used in drug delivery formulations such as micelles, vesicles, liquid crystalline phases, microemulsions, polymer gels, aerosols, polymer-polymer and polymer-surfactant complexes will be illustrated in this chapter and their main physicochemical properties will be highlighted, keeping in mind their relevance to the drug delivery research field.


Self-assembly Amphiphilic Nanoaggregates Phase diagrams Drug delivery systems Personalized medicine 


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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Salomé dos Santos
    • 1
  • Bruno Medronho
    • 2
  • Tiago dos Santos
    • 3
  • Filipe E. Antunes
    • 1
    Email author
  1. 1.Department of ChemistryUniversity of CoimbraCoimbraPortugal
  2. 2.Institute for Biotechnology and Bioengineering, Centre of Genomics and Biotechnology (IBB/CGB), Faculty of Sciences and TechnologyUniversity of AlgarveFaroPortugal
  3. 3.Centre for BioNano Interactions, School of Chemistry and Chemical BiologyUniversity College DublinDublin 4Ireland

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