Abstract
Like in many other research fields, scientific simulation has been established as a crucial element in the design technology of drug delivery systems. Modern multi-scale modeling and simulation techniques, supported by advanced and high-performance computational resources, form a cost-effective complement and/or alternative to the experimentally based trial-and-error approach traditionally used in the development of new drugs. This chapter gives a short overview of the application of modern modeling and simulation techniques within the context of drug delivery systems. Different approaches will be considered depending on the quality and the scale of organization of matter, ranging from picometers to nanoscale and beyond. Molecular modeling and simulation tools will be put in the perspective of their important role in the development of new drugs and in the simulation of their behavior. Such approach enables the engineering of tailored carriers for a specific drug, the optimization of its effectiveness, as well as the understanding at an atomistic level of how they interact with the surroundings. The application of computational flow models to drug delivery systems will be systematically addressed for hydrophobic and hydrophilic molecules. The current development of drug transport modeling by applying state-of-art computational fluid dynamics will also be described based on the drug release mechanism for diffusion, swelling and erosion-controlled systems. Finally, a brief prospective view on the high-performance scientific techniques underlying the advanced scientific simulation methods will be given.
Keywords
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- 1.
The complexity of the wavefunction based methods is usually emphasized through an example like the following. For a single oxygen atom, having eight electrons, its wavefunction ψ(r 1, r 2, ⋯ , r 8) is a function of 24 coordinates. Considering that just the modest number of 10 ψ values are to be stored for each coordinate, a total of 1024 values need to be stored. Could this be done on DVDs with a capacity of 5 GB, more than 1014 DVDs would be necessary. With a weight of 10 g per DVD, this would correspond to more than 109 ton DVDs!
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Ferreira, A.F., Lopes, R.J., Simões, P.N. (2013). In Silico Research in Drug Delivery Systems. In: Coelho, J. (eds) Drug Delivery Systems: Advanced Technologies Potentially Applicable in Personalised Treatment. Advances in Predictive, Preventive and Personalised Medicine, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6010-3_10
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