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Regulation of Muscle Stem Cell Quiescent and Undifferentiated State: Roles of Hesr1 and Hesr3 Genes

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Tumor Dormancy, Quiescence, and Senescence, Volume 1

Part of the book series: Tumor Dormancy and Cellular Quiescence and Senescence ((DOQU,volume 1))

Abstract

Skeletal muscle stem cells, which are called “muscle satellite cells”, are tissue-specific monopotent stem cells in skeletal muscle that play central roles in postnatal muscle growth and regeneration. Similar to other stem cells in the body, muscle satellite cells are maintained in an undifferentiated quiescent state in adult skeletal muscle. Loss or dysfunction of satellite cells is observed in neuromuscular disorders and during the aging processes, which result in the loss of myofibers and muscle force. Hence, investigation of the molecular maintenance mechanism of muscle satellite cells is one of the important areas of interests in skeletal muscle biology. In this chapter, we introduce muscle satellite cells and discuss the maintenance mechanisms of muscle satellite cell based on our Hesr1 and Hesr3 results.

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Acknowledgements

We thank Katherine Ono for reading this manuscript. This work was supported by JSPS KAKENHI grant (18800023 to S.F.), MEXT KAKENHI grant (20700358 to S.F.), Intramural Research Grant (22-1 to S.F.) for Neurological and Psychiatric Disorders of NCNP, the Nakatomi Foundation (to S.F.).

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Authors and Affiliations

  1. Laboratory of Molecular and Cellular Physiology, Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita City, Osaka, Japan

    Masahiko Yamaguchi & So-ichiro Fukada

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  1. Masahiko Yamaguchi
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  2. So-ichiro Fukada
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Correspondence to So-ichiro Fukada .

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  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

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Yamaguchi, M., Fukada, Si. (2013). Regulation of Muscle Stem Cell Quiescent and Undifferentiated State: Roles of Hesr1 and Hesr3 Genes. In: Hayat, M. (eds) Tumor Dormancy, Quiescence, and Senescence, Volume 1. Tumor Dormancy and Cellular Quiescence and Senescence, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5958-9_9

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