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Cilia and Nervous System Development and Function pp 165–191Cite as

Neuronal Cilia and Obesity

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Abstract

Obesity is an emerging public health concern that has numerous secondary health consequences, including heart disease, high blood pressure, diabetes mellitus, osteoarthritis, and overall reduced quality of life. Historically, obesity has been viewed as increased body fat caused by overconsumption of food, combined with the sedentary lifestyle of modern society. Simply put, energy input exceeds energy output, creating an excess in fat mass. This viewpoint largely focuses on environmental and social factors in the obesity epidemic. However, it fails to take into account a growing body of evidence from several monogenetic human obesity disorders and mutant mouse and rat obesity models that indicate a profound role for genetic factors. Although most of these monogenetic human conditions are rare, it is clear that the study of their molecular and cellular etiology will offer insights into the mechanisms that regulate appetite and satiety. The objectives of this review are to discuss how mutations in genes required for the formation or function of the cilium result in obesity in human and mouse models and how the cilium may function to regulate appetite and satiation responses.

Authors Nicolas F. Berbari and Raymond C. Pasek contributed equally to this work.

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Acknowledgements

We thank Yoder lab members for suggestions and critical review of the chapter. This work was supported in part by NIH RO1 DK075996 to BKY. NFB was supported by NRSA F32 DK088404, RCP was supported by T32 GM008111 to (Dr. Yoder).

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  1. Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA

    Nicolas F. Berbari, Raymond C. Pasek & Bradley K. Yoder Ph.D.

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  1. Nicolas F. Berbari
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Correspondence to Bradley K. Yoder Ph.D. .

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  1. , Anatomy and Cell Biology, University of Heidelberg, Im Neuenheimer Feld 307, Heidelberg, 69120, Germany

    Kerry L. Tucker

  2. , Human Genetics, Emory University, Michael Street, Suite 301 615, Atlanta, 30322, Georgia, USA

    Tamara Caspary

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Berbari, N.F., Pasek, R.C., Yoder, B.K. (2013). Neuronal Cilia and Obesity. In: Tucker, K., Caspary, T. (eds) Cilia and Nervous System Development and Function. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5808-7_6

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