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Polypharmacy in Psychiatry Practice, Volume II pp 263–274Cite as

Polypharmacy and Potentially Inappropriate Medication Use Among Elders with Dementia

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Abstract

Senior patients are at hight risk of polymorbidity which may correspond with hight risk of polypharmacy. Benefit of pharmacotherapy on one hand and risk of pharmacotherapy on the other hand are two different scales of one balance we have to measure on.

The paper shows basic principles of safe and efficient pharmacotherapy in the elderly – including inappropriate psychotropic drugs and drug-drug interactions which should be avoided.

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Abbreviations

BZD:

benzodiazepines

CYP:

cytochrome P450 superfamily

ECG:

electrocardiography

MAO inhibitors:

monoamine oxidase inhibitors

MASSA:

melatonin agonist and selective serotonin antagonist

NASSA:

noradrenergic and specific serotonergic antidepressant

NDRI:

noradrenergic and dopaminergic reuptake inhibitor

NSAID’s:

nonsteroid anti-inflammatory drugs

QT:

QT interval in electrocardiogram

SARI:

serotonin antagonist reuptake inhibitor

SIADH:

syndrome of inappropriate antidiuretic hormone secretion

SNRI:

serotonin noradrenaline reuptake inhibitors

SSRI:

selective serotonin reuptake inhibitors

TCA’s:

tricyclic antidepressants

“Z”-agents:

zolpidem zopiclone, zaleplone

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Acknowledgement

The paper was not supported by any grant or other financial support. Ethical hazard is therefore excluded.

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Authors and Affiliations

  1. Mental Hospital Kromeriz and Palacky University Olomouc, Praha, Czech Republic

    Jan Luzny M.D.

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  1. Jan Luzny M.D.
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Correspondence to Jan Luzny M.D. .

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Editors and Affiliations

  1. Sha'ar Menashe Mental Health Center, Hadera, 38814, Israel

    Michael S. Ritsner

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Luzny, J. (2013). Polypharmacy and Potentially Inappropriate Medication Use Among Elders with Dementia. In: Ritsner, M. (eds) Polypharmacy in Psychiatry Practice, Volume II. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5799-8_13

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