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Vector Technology and Cell Targeting: Peptide-Tagged Adenoviral Vectors as a Powerful Tool for Cell Specific Targeting

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Regenerative Medicine

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Abstract

A pre-requisite for efficient and successful treatment of diseases consists in the development of technologies which yield the transfer of therapeutic genes and drugs exclusively to target cells and avoid therapy related effects or toxicity in normal cells. Targeted gene therapy is emerging as a powerful approach to enhance the efficacy, selectivity and safety of gene delivery. Currently, the most efficient and popular way of introducing genes into cells is by means of viral vectors. Attractive targeting strategies of viruses are either by regulation of transgene expression through tissue specific promoters and integration of transcriptionally active elements (molecular targeting), or by selective recognition of individual cellular receptors (physical or transductional targeting). The latter can be achieved by alteration of the native viral tropism in conjunction with redirection of binding to target cell receptors. Receptor-targeting will be performed by linking or integration of adapter molecules to the viral surface (genetic modification). On the basis of recent knowledge and different limitations in practice, our focus is concentrated on the improvement of adenoviral vector systems for selective transduction of different cell types by directing adenovirus (Ad) to specific ligands. Those peptide-tagged Ad vectors have shown impressive tumor and stem cell specific gene transfer activity in vitro and after systemic administration in several in vivo models. They not only offer new opportunities to further delineate stem cell properties in their natural environment but may also enable more effective cancer therapies for patients with metastatic disease.

Authors contibuted equally.

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References

  • Ahmed AU, Thaci B, Alexiades NG, Han Y, Qian S, Liu F, Balyasnikova IV, Ulasov IY, Aboody KS, Lesniak MS (2011) Neural stem cell-based cell carriers enhance therapeutic efficacy of an oncolytic adenovirus in an orthotopic mouse model of human glioblastoma. Mol Ther 19:1714–1726

    Article  PubMed  CAS  Google Scholar 

  • Alemany R, Curiel DT (2001) CAR-binding ablation does not change biodistribution and toxicity of adenoviral vectors. Gene Ther 8:1347–1353

    Article  PubMed  CAS  Google Scholar 

  • Alemany R, Balague C, Curiel DT (2000) Replicative adenoviruses for cancer therapy. Nat Biotechnol 18:723–727

    Article  PubMed  CAS  Google Scholar 

  • Alvarez-Erviti L, Seow Y, Yin H, Betts C, Lakhal S, Wood MJ (2011) Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nat Biotechnol 29:341–345

    Article  PubMed  CAS  Google Scholar 

  • Arap W, Pasqualini R (2001) The human vascular mapping project. Selection and utilization of molecules for tumor endothelial targeting. Haemostasis 31(Suppl 1):30–31

    PubMed  CAS  Google Scholar 

  • Arap W, Pasqualini R, Ruoslahti E (1998) Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model. Science 279:377–380

    Article  PubMed  CAS  Google Scholar 

  • Arap W, Kolonin MG, Trepel M, Lahdenranta J, Cardo-Vila M, Giordano RJ, Mintz PJ, Ardelt PU, Yao VJ, Vidal CI, Chen L, Flamm A, Valtanen H, Weavind LM, Hicks ME, Pollock RE, Botz GH, Bucana CD, Koivunen E, Cahill D, Troncoso P, Baggerly KA, Pentz RD, Do KA, Logothetis CJ, Pasqualini R (2002) Steps toward mapping the human vasculature by phage display. Nat Med 8:121–127

    Article  PubMed  CAS  Google Scholar 

  • Armendariz-Borunda J, Bastidas-Ramirez BE, Sandoval-Rodriguez A, Gonzalez-Cuevas J, Gomez-Meda B, Garcia-Banuelos J (2011) Production of first generation adenoviral vectors for preclinical protocols: amplification, purification and functional titration. J Biosci Bioeng 112:415–421

    Article  PubMed  CAS  Google Scholar 

  • Arnberg N (2009) Adenovirus receptors: implications for tropism, treatment and targeting. Rev Med Virol 19:165–178

    Article  PubMed  CAS  Google Scholar 

  • Arnhold S, Kreppel F, Kandirali S, Lenartz D, Klinz FJ, Sturm V, Kochanek S, Andressen C, Addicks K (2002) Intracerebral transplantation and successful integration of astrocytes following genetic modification with a high-capacity adenoviral vector. Cell Transpl 11:663–670

    CAS  Google Scholar 

  • Arnhold S, Hilgers M, Lenartz D, Semkova I, Kochanek S, Voges J, Andressen C, Addicks K (2003) Neural precursor cells as carriers for a gene therapeutical approach in tumor therapy. Cell Transpl 12:827–837

    CAS  Google Scholar 

  • Auer R, Bell JC (2012) Oncolytic viruses: smart therapeutics for smart cancers. Future Oncol (London, England) 8:1–4

    Article  Google Scholar 

  • Bangari DS, Mittal SK (2006) Current strategies and future directions for eluding adenoviral vector immunity. Curr Gene Ther 6:215–226

    Article  PubMed  CAS  Google Scholar 

  • Barnett BG, Crews CJ, Douglas JT (2002a) Targeted adenoviral vectors. Biochim Biophys Acta 1575:1–14

    Article  PubMed  CAS  Google Scholar 

  • Barnett BG, Tillman BW, Curiel DT, Douglas JT (2002b) Dual targeting of adenoviral vectors at the levels of transduction and transcription enhances the specificity of gene expression in cancer cells. Mol Ther 6:377–385

    Article  PubMed  CAS  Google Scholar 

  • Barry MA, Dower WJ, Johnston SA (1996) Toward cell-targeting gene therapy vectors: selection of cell-binding peptides from random peptide-presenting phage libraries. Nat Med 2:299–305

    Article  PubMed  CAS  Google Scholar 

  • Bartel M, Schaffer D, Buning H (2011) Enhancing the clinical potential of AAV vectors by capsid engineering to evade pre-existing immunity. Front Microbiol 2:204

    Article  PubMed  Google Scholar 

  • Bauerschmitz GJ, Lam JT, Kanerva A, Suzuki K, Nettelbeck DM, Dmitriev I, Krasnykh V, Mikheeva GV, Barnes MN, Alvarez RD, Dall P, Alemany R, Curiel DT, Hemminki A (2002a) Treatment of ovarian cancer with a tropism modified oncolytic adenovirus. Cancer Res 62:1266–1270

    PubMed  CAS  Google Scholar 

  • Bauerschmitz GJ, Nettelbeck DM, Kanerva A, Baker AH, Hemminki A, Reynolds PN, Curiel DT (2002b) The flt-1 promoter for transcriptional targeting of teratocarcinoma. Cancer Res 62:1271–1274

    PubMed  CAS  Google Scholar 

  • Baum C (2011) Gene therapy for SCID-X1: focus on clinical data. Mol Ther 19:2103–2104

    Article  PubMed  CAS  Google Scholar 

  • Belousova N, Krendelchtchikova V, Curiel DT, Krasnykh V (2002) Modulation of adenovirus vector tropism via incorporation of polypeptide ligands into the fiber protein. J Virol 76:8621–8631

    Article  PubMed  CAS  Google Scholar 

  • Belousova N, Mikheeva G, Gelovani J, Krasnykh V (2008) Modification of adenovirus capsid with a designed protein ligand yields a gene vector targeted to a major molecular marker of cancer. J Virol 82:630–637

    Article  PubMed  CAS  Google Scholar 

  • Bennett J, Ashtari M, Wellman J, Marshall KA, Cyckowski LL, Chung DC, McCague S, Pierce EA, Chen Y, Bennicelli JL, Zhu X, Ying GS, Sun J, Wright JF, Auricchio A, Simonelli F, Shindler KS, Mingozzi F, High KA, Maguire AM (2012) AAV2 gene therapy readministration in three adults with congenital blindness. Sci Trans Med 4:120ra115

    Article  CAS  Google Scholar 

  • Bergelson JM, Cunningham JA, Droguett G, Kurt-Jones EA, Krithivas A, Hong JS, Horwitz MS, Crowell RL, Finberg RW (1997) Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5. Science 275:1320–1323

    Article  PubMed  CAS  Google Scholar 

  • Bewley MC, Springer K, Zhang YB, Freimuth P, Flanagan JM (1999) Structural analysis of the mechanism of adenovirus binding to its human cellular receptor, CAR. Science 286:1579–1583

    Article  PubMed  CAS  Google Scholar 

  • Bilbao G, Contreras JL, Dmitriev I, Smyth CA, Jenkins S, Eckhoff D, Thomas F, Thomas J, Curiel DT (2002) Genetically modified adenovirus vector containing an RGD peptide in the HI loop of the fiber knob improves gene transfer to nonhuman primate isolated pancreatic islets. Am J Transplant 2:237–243

    Article  PubMed  CAS  Google Scholar 

  • Bjorklund A, Kirik D, Rosenblad C, Georgievska B, Lundberg C, Mandel RJ (2000) Towards a neuroprotective gene therapy for Parkinson’s disease: use of adenovirus, AAV and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in the rat Parkinson model. Brain Res 886:82–98

    Article  PubMed  CAS  Google Scholar 

  • Blurton-Jones M, Kitazawa M, Martinez-Coria H, Castello NA, Müller FJ, Loring JF, Yamasaki TR, Poon WW, Green KN, LaFerla FM (2009) Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease. Proc Natl Acad Sci USA 106:13594–13599

    Article  PubMed  CAS  Google Scholar 

  • Böckmann M, Drosten M, Pützer BM (2005a) Discovery of targeting peptides for selective therapy of medullary thyroid carcinoma. J Gene Med 7:179–188

    Article  PubMed  CAS  Google Scholar 

  • Böckmann M, Hilken G, Schmidt A, Cranston AN, Tannapfel A, Drosten M, Frilling A, Ponder BA, Pützer BM (2005b) Novel SRESPHP peptide mediates specific binding to primary medullary thyroid carcinoma after systemic injection. Hum Gene Ther 16:1267–1275

    Article  PubMed  Google Scholar 

  • Boulaire J, Balani P, Wang S (2009) Transcriptional targeting to brain cells: engineering cell type-specific promoter containing cassettes for enhanced transgene expression. Adv Drug Deliv Rev 61:589–602

    Article  PubMed  CAS  Google Scholar 

  • Bruder JT, Kovesdi I (1997) Adenovirus infection stimulates the Raf/MAPK signaling pathway and induces interleukin-8 expression. J Virol 71:398–404

    PubMed  CAS  Google Scholar 

  • Brunetti-Pierri N, Ng P (2008) Progress and prospects: gene therapy for genetic diseases with helper-dependent adenoviral vectors. Gene Ther 15:553–560

    Article  PubMed  CAS  Google Scholar 

  • Brunetti-Pierri N, Ng P (2011) Helper-dependent adenoviral vectors for liver-directed gene therapy. Hum Mol Genet 20:R7–R13

    Article  PubMed  CAS  Google Scholar 

  • Carpentier DC, Vevis K, Trabalza A, Georgiadis C, Ellison SM, Asfahani RI, Mazarakis ND (2012) Enhanced pseudotyping efficiency of HIV-1 lentiviral vectors by a rabies/vesicular stomatitis virus chimeric envelope glycoprotein. Gene Ther 19:761–764

    Google Scholar 

  • Casper D, Engstrom SJ, Mirchandani GR, Pidel A, Palencia D, Cho PH, Brownlee M, Edelstein D, Federoff HJ, Sonstein WJ (2002) Enhanced vascularization and survival of neural transplants with ex vivo angiogenic gene transfer. Cell Transpl 11:331–349

    Google Scholar 

  • Chailertvanitkul VA, Pouton CW (2010) Adenovirus: a blueprint for non-viral gene delivery. Curr Opin Biotechnol 21:627–632

    Article  PubMed  CAS  Google Scholar 

  • Chang DK, Chiu CY, Kuo SY, Lin WC, Lo A, Wang YP, Li PC, Wu HC (2009) Antiangiogenic targeting liposomes increase therapeutic efficacy for solid tumors. J Biol Chem 284:12905–12916

    Article  PubMed  CAS  Google Scholar 

  • Check E (2002) Gene therapy: shining hopes dented – but not dashed. Nature 420:735

    Article  PubMed  CAS  Google Scholar 

  • Chi L, Ke Y, Luo C, Li B, Gozal D, Kalyanaraman B, Liu R (2006) Motor neuron degeneration promotes neural progenitor cell proliferation, migration, and neurogenesis in the spinal cords of amyotrophic lateral sclerosis mice. Stem Cells 24:34–43

    Article  PubMed  Google Scholar 

  • Chiocca EA, Aguilar LK, Bell SD, Kaur B, Hardcastle J, Cavaliere R, McGregor J, Lo S, Ray-Chaudhuri A, Chakravarti A, Grecula J, Newton H, Harris KS, Grossman RG, Trask TW, Baskin DS, Monterroso C, Manzanera AG, Aguilar-Cordova E, New PZ (2011) Phase IB study of gene-mediated cytotoxic immunotherapy adjuvant to up-front surgery and intensive timing radiation for malignant glioma. J Clin Oncol 29:3611–3619

    Article  PubMed  CAS  Google Scholar 

  • Clement N, Knop DR, Byrne BJ (2009) Large-scale adeno-associated viral vector production using a herpesvirus-based system enables manufacturing for clinical studies. Hum Gene Ther 20:796–806

    Article  PubMed  CAS  Google Scholar 

  • Coffin SE (2000) Rotavirus vaccines: current controversies and future directions. Curr Infect Dis Rep 2:68–72

    Article  PubMed  Google Scholar 

  • Coughlan L, Alba R, Parker AL, Bradshaw AC, McNeish IA, Nicklin SA, Baker AH (2010) Tropism-modification strategies for targeted gene delivery using adenoviral vectors. Viruses 2:2290–2355

    Article  PubMed  CAS  Google Scholar 

  • Cronin J, Zhang XY, Reiser J (2005) Altering the tropism of lentiviral vectors through pseudotyping. Curr Gene Ther 5:387–398

    Article  PubMed  CAS  Google Scholar 

  • Croyle MA, Chirmule N, Zhang Y, Wilson JM (2002) PEGylation of E1-deleted adenovirus vectors allows significant gene expression on readministration to liver. Hum Gene Ther 13:1887–1900

    Article  PubMed  CAS  Google Scholar 

  • Croyle MA, Le HT, Linse KD, Cerullo V, Toietta G, Beaudet A, Pastore L (2005) PEGylated helper-dependent adenoviral vectors: highly efficient vectors with an enhanced safety profile. Gene Ther 12:579–587

    Article  PubMed  CAS  Google Scholar 

  • Deglon N, Hantraye P (2005) Viral vectors as tools to model and treat neurodegenerative disorders. J Gene Med 7:530–539

    Article  PubMed  CAS  Google Scholar 

  • Di Niro R, Ziller F, Florian F, Crovella S, Stebel M, Bestagno M, Burrone O, Bradbury AR, Secco P, Marzari R, Sblattero D (2007) Construction of miniantibodies for the in vivo study of human autoimmune diseases in animal models. BMC Biotechnol 7:46

    Article  PubMed  CAS  Google Scholar 

  • Di Paolo NC, Shayakhmetov DM (2009) Adenovirus de-targeting from the liver. Curr Opin Mol Ther 11:523–531

    PubMed  Google Scholar 

  • Dias-Neto E, Nunes DN, Giordano RJ, Sun J, Botz GH, Yang K, Setubal JC, Pasqualini R, Arap W (2009) Next-generation phage display: integrating and comparing available molecular tools to enable cost-effective high-throughput analysis. PLoS One 4:e8338

    Article  PubMed  CAS  Google Scholar 

  • Dmitriev I, Krasnykh V, Miller CR, Wang M, Kashentseva E, Mikheeva G, Belousova N, Curiel DT (1998) An adenovirus vector with genetically modified fibers demonstrates expanded tropism via utilization of a coxsackievirus and adenovirus receptor-independent cell entry mechanism. J Virol 72:9706–9713

    PubMed  CAS  Google Scholar 

  • Dmitriev I, Kashentseva E, Rogers BE, Krasnykh V, Curiel DT (2000) Ectodomain of coxsackievirus and adenovirus receptor genetically fused to epidermal growth factor mediates adenovirus targeting to epidermal growth factor receptor-positive cells. J Virol 74:6875–6884

    Article  PubMed  CAS  Google Scholar 

  • Doetsch F, Alvarez-Buylla A (1996) Network of tangential pathways for neuronal migration in adult mammalian brain. Proc Natl Acad Sci USA 93:14895–14900

    Article  PubMed  CAS  Google Scholar 

  • Dong Z, Nor JE (2009) Transcriptional targeting of tumor endothelial cells for gene therapy. Adv Drug Deliv Rev 61:542–553

    Article  PubMed  CAS  Google Scholar 

  • Dorer DE, Nettelbeck DM (2009) Targeting cancer by transcriptional control in cancer gene therapy and viral oncolysis. Adv Drug Deliv Rev 61:554–571

    Article  PubMed  CAS  Google Scholar 

  • Dormond E, Kamen AA (2011) Manufacturing of adenovirus vectors: production and purification of helper dependent adenovirus. Method Mol Biol 737:139–156

    Article  CAS  Google Scholar 

  • Dormond E, Meneses-Acosta A, Jacob D, Durocher Y, Gilbert R, Perrier M, Kamen A (2009) An efficient and scalable process for helper-dependent adenoviral vector production using polyethylenimine-adenofection. Biotechnol Bioeng 102:800–810

    Article  PubMed  CAS  Google Scholar 

  • Douglas JT, Rogers BE, Rosenfeld ME, Michael SI, Feng M, Curiel DT (1996) Targeted gene delivery by tropism-modified adenoviral vectors. Nat Biotechnol 14:1574–1578

    Article  PubMed  CAS  Google Scholar 

  • Douglas JT, Miller CR, Kim M, Dmitriev I, Mikheeva G, Krasnykh V, Curiel DT (1999) A system for the propagation of adenoviral vectors with genetically modified receptor specificities. Nat Biotechnol 17:470–475

    Article  PubMed  CAS  Google Scholar 

  • Duan D (2011) Gene delivery to the heart: an updated review on vectors and methods. J Gene Med 13:556

    Article  PubMed  Google Scholar 

  • Einfeld DA, Schroeder R, Roelvink PW, Lizonova A, King CR, Kovesdi I, Wickham TJ (2001) Reducing the native tropism of adenovirus vectors requires removal of both CAR and integrin interactions. J Virol 75:11284–11291

    Article  PubMed  CAS  Google Scholar 

  • Essler M, Ruoslahti E (2002) Molecular specialization of breast vasculature: a breast-homing phage-displayed peptide binds to aminopeptidase P in breast vasculature. Proc Natl Acad Sci USA 99:2252–2257

    Article  PubMed  CAS  Google Scholar 

  • Eto Y, Gao JQ, Sekiguchi F, Kurachi S, Katayama K, Mizuguchi H, Hayakawa T, Tsutsumi Y, Mayumi T, Nakagawa S (2004) Neutralizing antibody evasion ability of adenovirus vector induced by the bioconjugation of methoxypolyethylene glycol succinimidyl propionate (MPEG-SPA). Biol Pharm Bull 27:936–938

    Article  PubMed  CAS  Google Scholar 

  • Eto Y, Gao JQ, Sekiguchi F, Kurachi S, Katayama K, Maeda M, Kawasaki K, Mizuguchi H, Hayakawa T, Tsutsumi Y, Mayumi T, Nakagawa S (2005) PEGylated adenovirus vectors containing RGD peptides on the tip of PEG show high transduction efficiency and antibody evasion ability. J Gene Med 7:604–612

    Article  PubMed  CAS  Google Scholar 

  • Eto Y, Yoshioka Y, Ishida T, Yao X, Morishige T, Narimatsu S, Mizuguchi H, Mukai Y, Okada N, Kiwada H, Nakagawa S (2010) Optimized PEGylated adenovirus vector reduces the anti-vector humoral immune response against adenovirus and induces a therapeutic effect against metastatic lung cancer. Biol Pharm Bull 33:1540–1544

    Article  PubMed  CAS  Google Scholar 

  • Filippov V, Kronenberg G, Pivneva T, Reuter K, Steiner B, Wang LP, Yamaguchi M, Kettenmann H, Kempermann G (2003) Subpopulation of nestin-expressing progenitor cells in the adult murine hippocampus shows electrophysiological and morphological characteristics of astrocytes. Mol Cell Neurosci 23:373–382

    Article  PubMed  CAS  Google Scholar 

  • Fisher KD, Stallwood Y, Green NK, Ulbrich K, Mautner V, Seymour LW (2001) Polymer-coated adenovirus permits efficient retargeting and evades neutralising antibodies. Gene Ther 8:341–348

    Article  PubMed  CAS  Google Scholar 

  • Galvez J, Lecina M, Sola C, Cairo JJ, Godia F (2012) Optimization of HEK-293S cell cultures for the production of adenoviral vectors in bioreactors using on-line OUR measurements. J Biotechnol 157:214–222

    Article  PubMed  CAS  Google Scholar 

  • Gao JQ, Eto Y, Yoshioka Y, Sekiguchi F, Kurachi S, Morishige T, Yao X, Watanabe H, Asavatanabodee R, Sakurai F, Mizuguchi H, Okada Y, Mukai Y, Tsutsumi Y, Mayumi T, Okada N, Nakagawa S (2007) Effective tumor targeted gene transfer using PEGylated adenovirus vector via systemic administration. J Control Release 122:102–110

    Article  PubMed  CAS  Google Scholar 

  • Gaspar HB, Cooray S, Gilmour KC, Parsley KL, Zhang F, Adams S, Bjorkegren E, Bayford J, Brown L, Davies EG, Veys P, Fairbanks L, Bordon V, Petropolou T, Kinnon C, Thrasher AJ (2011) Hematopoietic stem cell gene therapy for adenosine deaminase-deficient severe combined immunodeficiency leads to long-term immunological recovery and metabolic correction. Sci Trans Med 3:97ra80

    Article  CAS  Google Scholar 

  • Geraerts M, Eggermont K, Hernandez-Acosta P, Garcia-Verdugo JM, Baekelandt V, Debyser Z (2006) Lentiviral vectors mediate efficient and stable gene transfer in adult neural stem cells in vivo. Hum Gene Ther 17:635–650

    Article  PubMed  CAS  Google Scholar 

  • Giordano RJ, Edwards JK, Tuder RM, Arap W, Pasqualini R (2009) Combinatorial ligand-directed lung targeting. Proc Am Thorac Soc 6:411–415

    Article  PubMed  CAS  Google Scholar 

  • Glasgow JN, Everts M, Curiel DT (2006) Transductional targeting of adenovirus vectors for gene therapy. Cancer Gene Ther 13:830–844

    Article  PubMed  CAS  Google Scholar 

  • Glass R, Synowitz M, Kronenberg G, Walzlein JH, Markovic DS, Wang LP, Gast D, Kiwit J, Kempermann G, Kettenmann H (2005) Glioblastoma-induced attraction of endogenous neural precursor cells is associated with improved survival. J Neurosci 25:2637–2646

    Article  PubMed  CAS  Google Scholar 

  • Glorioso JC, Fink DJ (2009) Herpes vector-mediated gene transfer in the treatment of chronic pain. Mol Ther 17:13–18

    Article  PubMed  CAS  Google Scholar 

  • Green NK, Herbert CW, Hale SJ, Hale AB, Mautner V, Harkins R, Hermiston T, Ulbrich K, Fisher KD, Seymour LW (2004) Extended plasma circulation time and decreased toxicity of polymer-coated adenovirus. Gene Ther 11:1256–1263

    Article  PubMed  CAS  Google Scholar 

  • Gregory SM, Nazir SA, Metcalf JP (2011) Implications of the innate immune response to adenovirus and adenoviral vectors. Future Virol 6:357–374

    Article  PubMed  CAS  Google Scholar 

  • Greig JA, Buckley SM, Waddington SN, Parker AL, Bhella D, Pink R, Rahim AA, Morita T, Nicklin SA, McVey JH, Baker AH (2009) Influence of coagulation factor x on in vitro and in vivo gene delivery by adenovirus (Ad) 5, Ad35, and chimeric Ad5/Ad35 vectors. Mol Ther 17:1683–1691

    Article  PubMed  CAS  Google Scholar 

  • Guan YS, Liu Y, He Q, Li X, Yang L, Hu Y, La Z (2011) p53 gene therapy in combination with transcatheter arterial chemoembolization for HCC: one-year follow-up. World J Gastroenterol 17:2143–2149

    Article  PubMed  CAS  Google Scholar 

  • Guo X, Huang L (2012) Recent advances in nonviral vectors for gene delivery. Acc Chem Res 45:971–979

    Google Scholar 

  • Hacein-Bey-Abina S, Von Kalle C, Schmidt M, McCormack MP, Wulffraat N, Leboulch P, Lim A, Osborne CS, Pawliuk R, Morillon E, Sorensen R, Forster A, Fraser P, Cohen JI, de Saint Basile G, Alexander I, Wintergerst U, Frebourg T, Aurias A, Stoppa-Lyonnet D, Romana S, Radford-Weiss I, Gross F, Valensi F, Delabesse E, Macintyre E, Sigaux F, Soulier J, Leiva LE, Wissler M, Prinz C, Rabbitts TH, Le Deist F, Fischer A, Cavazzana-Calvo M (2003) LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science 302:415–419

    Article  PubMed  CAS  Google Scholar 

  • Haisma HJ, Grill J, Curiel DT, Hoogeland S, van Beusechem VW, Pinedo HM, Gerritsen WR (2000) Targeting of adenoviral vectors through a bispecific single-chain antibody. Cancer Gene Ther 7:901–904

    Article  PubMed  CAS  Google Scholar 

  • Haisma HJ, Kamps GK, Bouma A, Geel TM, Rots MG, Kariath A, Bellu AR (2010) Selective targeting of adenovirus to alphavbeta3 integrins, VEGFR2 and Tie2 endothelial receptors by angio-adenobodies. Int J Pharm 391:155–161

    Article  PubMed  CAS  Google Scholar 

  • Hartkopf AD, Fehm T, Wallwiener D, Lauer UM (2011) Oncolytic virotherapy of breast cancer. Gyn Oncol 123:164–171

    Article  Google Scholar 

  • Haviv YS, Curiel DT (2003) Engineering regulatory elements for conditionally-replicative adeno-viruses. Curr Gene Ther 3:357–385

    Article  PubMed  CAS  Google Scholar 

  • He Q, Liu Y, Zou Q, Guan YS (2011) Transarterial injection of H101 in combination with chemoembolization overcomes recurrent hepatocellular carcinoma. World J Gastroenterol 17:2353–2355

    Article  PubMed  Google Scholar 

  • Hecht JR, Bedford R, Abbruzzese JL, Lahoti S, Reid TR, Soetikno RM, Kirn DH, Freeman SM (2003) A phase I/II trial of intratumoral endoscopic ultrasound injection of ONYX-015 with intravenous gemcitabine in unresectable pancreatic carcinoma. Clin Cancer Res 9:555–561

    PubMed  CAS  Google Scholar 

  • Hecht JR, Farrell JJ, Senzer N, Nemunaitis J, Rosemurgy A, Chung T, Hanna N, Chang KJ, Javle M, Posner M, Waxman I, Reid A, Erickson R, Canto M, Chak A, Blatner G, Kovacevic M, Thornton M (2012) EUS or percutaneously guided intratumoral TNFerade biologic with 5-fluorouracil and radiotherapy for first-line treatment of locally advanced pancreatic cancer: a phase I/II study. Gastrointest Endosc 75:332–338

    Article  PubMed  Google Scholar 

  • Hedley SJ, Chen J, Mountz JD, Li J, Curiel DT, Korokhov N, Kovesdi I (2006) Targeted and shielded adenovectors for cancer therapy. Cancer Immunol Immunother 55:1412–1419

    Article  PubMed  CAS  Google Scholar 

  • Hemminki A, Alvarez RD (2002) Adenoviruses in oncology: a viable option? Bio Drugs 16:77–87

    Google Scholar 

  • Hemminki A, Belousova N, Zinn KR, Liu B, Wang M, Chaudhuri TR, Rogers BE, Buchsbaum DJ, Siegal GP, Barnes MN, Gomez-Navarro J, Curiel DT, Alvarez RD (2001) An adenovirus with enhanced infectivity mediates molecular chemotherapy of ovarian cancer cells and allows imaging of gene expression. Mol Ther 4:223–231

    Article  PubMed  CAS  Google Scholar 

  • Hesse A, Kosmides D, Kontermann RE, Nettelbeck DM (2007) Tropism modification of adenovirus vectors by peptide ligand insertion into various positions of the adenovirus serotype 41 short-fiber knob domain. J Virol 81:2688–2699

    Article  PubMed  CAS  Google Scholar 

  • Hidaka C, Milano E, Leopold PL, Bergelson JM, Hackett NR, Finberg RW, Wickham TJ, Kovesdi I, Roelvink P, Crystal RG (1999) CAR-dependent and CAR-independent pathways of adenovirus vector-mediated gene transfer and expression in human fibroblasts. J Clin Invest 103:579–587

    Article  PubMed  CAS  Google Scholar 

  • Hildebrandt S, Schmidt A, Stoll A, Schmitt O, Köhling R, Wree A, Haas SJ, Pützer BM (2010) Targeting of neural stem cells in the hippocampus of adult rats by custom-made Ad vectors. Brain Struct Funct 215:105–113

    Article  PubMed  CAS  Google Scholar 

  • Hofherr SE, Shashkova EV, Weaver EA, Khare R, Barry MA (2008) Modification of adenoviral vectors with polyethylene glycol modulates in vivo tissue tropism and gene expression. Mol Ther 16:1276–1282

    Article  PubMed  CAS  Google Scholar 

  • Hogg RT, Thorpe P, Gerard RD (2011) Retargeting adenoviral vectors to improve gene transfer into tumors. Cancer Gene Ther 18:275–287

    Article  PubMed  CAS  Google Scholar 

  • Hu C, Cela RG, Suzuki M, Lee B, Lipshutz GS (2011) Neonatal helper-dependent adenoviral vector gene therapy mediates correction of hemophilia A and tolerance to human factor VIII. Proc Natl Acad Sci USA 108:2082–2087

    Article  PubMed  CAS  Google Scholar 

  • Huard J, Lochmüller H, Acsadi G, Jani A, Massie B, Karpati G (1995) The route of administration is a major determinant of the transduction efficiency of rat tissues by adenoviral recombinants. Gene Ther 2:107–115

    PubMed  CAS  Google Scholar 

  • Hunter P (2011) The fourth front against cancer. The first clinical trials to test engineered viruses that attack tumour cells have yielded promising results for future cancer therapies. EMBO Rep 12:769–771

    Article  PubMed  CAS  Google Scholar 

  • Huston MW, van Til NP, Visser TP, Arshad S, Brugman MH, Cattoglio C, Nowrouzi A, Li Y, Schambach A, Schmidt M, Baum C, von Kalle C, Mavilio F, Zhang F, Blundell MP, Thrasher AJ, Verstegen MM, Wagemaker G (2011) Correction of murine SCID-X1 by lentiviral gene therapy using a codon-optimized IL2RG gene and minimal pretransplant conditioning. Mol Ther 19:1867–1877

    Article  PubMed  CAS  Google Scholar 

  • Ivanenkov VV, Felici F, Menon AG (1999) Targeted delivery of multivalent phage display vectors into mammalian cells. Biochim Biophys Acta 1448:463–472

    Article  PubMed  CAS  Google Scholar 

  • Izumi M, Kawakami Y, Glasgow JN, Belousova N, Everts M, Kim-Park S, Yamamoto S, Wang M, Le LP, Reynolds PN, Curiel DT (2005) In vivo analysis of a genetically modified adenoviral vector targeted to human CD40 using a novel transient transgenic model. J Gene Med 7:1517–1525

    Article  PubMed  CAS  Google Scholar 

  • Jafari M, Soltani M, Naahidi S, Karunaratne DN, Chen P (2012) Nonviral approach for targeted nucleic acid delivery. Curr Med Chem 19:197–208

    Article  PubMed  CAS  Google Scholar 

  • Jang JH, Schaffer DV, Shea LD (2011) Engineering biomaterial systems to enhance viral vector gene delivery. Mol Ther 19:1407–1415

    Article  PubMed  CAS  Google Scholar 

  • Jiang G, Xin Y, Zheng JN, Liu YQ (2011) Combining conditionally replicating adenovirus-mediated gene therapy with chemotherapy: a novel antitumor approach. Int J Cancer 129:263–274

    Article  PubMed  CAS  Google Scholar 

  • Joyce JA, Laakkonen P, Bernasconi M, Bergers G, Ruoslahti E, Hanahan D (2003) Stage-specific vascular markers revealed by phage display in a mouse model of pancreatic islet tumorigenesis. Cancer Cell 4:393–403

    Article  PubMed  CAS  Google Scholar 

  • Kajon AE, Erdman DD (2007) Assessment of genetic variability among subspecies b1 human adenoviruses for molecular epidemiology studies. Methods Mol Med 131:335–355

    Article  PubMed  CAS  Google Scholar 

  • Kajon AE, Moseley JM, Metzgar D, Huong HS, Wadleigh A, Ryan MA, Russell KL (2007) Molecular epidemiology of adenovirus type 4 infections in US military recruits in the postvaccination era (1997–2003). J Infect Dis 196:67–75

    Article  PubMed  CAS  Google Scholar 

  • Kaliberov SA, Kaliberova LN, Buchsbaum DJ (2005) Combined ionizing radiation and sKDR gene delivery for treatment of prostate carcinomas. Gene Ther 12:407–417

    Article  PubMed  CAS  Google Scholar 

  • Kanerva A, Mikheeva GV, Krasnykh V, Coolidge CJ, Lam JT, Mahasreshti PJ, Barker SD, Straughn M, Barnes MN, Alvarez RD, Hemminki A, Curiel DT (2002) Targeting adenovirus to the serotype 3 receptor increases gene transfer efficiency to ovarian cancer cells. Clin Cancer Res 8:275–280

    PubMed  CAS  Google Scholar 

  • Kashentseva EA, Seki T, Curiel DT, Dmitriev IP (2002) Adenovirus targeting to c-erbB-2 oncoprotein by single-chain antibody fused to trimeric form of adenovirus receptor ectodomain. Cancer Res 62:609–616

    PubMed  CAS  Google Scholar 

  • Kempermann G, Gast D, Kronenberg G, Yamaguchi M, Gage FH (2003) Early determination and long-term persistence of adult-generated new neurons in the hippocampus of mice. Development 130:391–399

    Article  PubMed  CAS  Google Scholar 

  • Kempermann G, Jessberger S, Steiner B, Kronenberg G (2004a) Milestones of neuronal development in the adult hippocampus. Trends Neurosci 27:447–452

    Article  PubMed  CAS  Google Scholar 

  • Kempermann G, Wiskott L, Gage FH (2004b) Functional significance of adult neurogenesis. Curr Opin Neurobiol 14:186–191

    Article  PubMed  CAS  Google Scholar 

  • Kim IH, Jozkowicz A, Piedra PA, Oka K, Chan L (2001) Lifetime correction of genetic deficiency in mice with a single injection of helper-dependent adenoviral vector. Proc Natl Acad Sci USA 98:13282–13287

    Article  PubMed  CAS  Google Scholar 

  • Kim DR, Park MY, Lim HJ, Park JS, Cho YJ, Lee SW, Yoon HI, Lee JH, Kim YS, Lee CT (2012) Combination therapy of conditionally replicating adenovirus and histone deacetylase inhibitors. Int J Mol Med 29:218–224

    PubMed  CAS  Google Scholar 

  • Kirby I, Davison E, Beavil AJ, Soh CP, Wickham TJ, Roelvink PW, Kovesdi I, Sutton BJ, Santis G (1999) Mutations in the DG loop of adenovirus type 5 fiber knob protein abolish high-affinity binding to its cellular receptor CAR. J Virol 73:9508–9514

    PubMed  CAS  Google Scholar 

  • Koizumi N, Mizuguchi H, Sakurai F, Yamaguchi T, Watanabe Y, Hayakawa T (2003) Reduction of natural adenovirus tropism to mouse liver by fiber-shaft exchange in combination with both CAR- and alphav integrin-binding ablation. J Virol 77:13062–13072

    Article  PubMed  CAS  Google Scholar 

  • Koynova R, Tenchov B (2011) Recent patents in cationic lipid carriers for delivery of nucleic acids. Recent Pat DNA Gene Seq 5:8–27

    Article  PubMed  CAS  Google Scholar 

  • Krasnykh V, Dmitriev I, Mikheeva G, Miller CR, Belousova N, Curiel DT (1998) Characterization of an adenovirus vector containing a heterologous peptide epitope in the HI loop of the fiber knob. J Virol 72:1844–1852

    PubMed  CAS  Google Scholar 

  • Kreppel F, Kochanek S (2008) Modification of adenovirus gene transfer vectors with synthetic polymers: a scientific review and technical guide. Mol Ther 16:16–29

    Article  PubMed  CAS  Google Scholar 

  • Kreppel F, Gackowski J, Schmidt E, Kochanek S (2005) Combined genetic and chemical capsid modifications enable flexible and efficient de- and retargeting of adenovirus vectors. Mol Ther 12:107–117

    Article  PubMed  CAS  Google Scholar 

  • Kuhlmann KF, Gouma DJ, Wesseling JG (2008) Adenoviral gene therapy for pancreatic cancer: where do we stand? Dig Surg 25:278–292

    Article  PubMed  CAS  Google Scholar 

  • Laakkonen P, Porkka K, Hoffman JA, Ruoslahti E (2002) A tumor-homing peptide with a targeting specificity related to lymphatic vessels. Nat Med 8:751–755

    PubMed  CAS  Google Scholar 

  • Lanciotti J, Song A, Doukas J, Sosnowski B, Pierce G, Gregory R, Wadsworth S, O’Riordan C (2003) Targeting adenoviral vectors using heterofunctional polyethylene glycol FGF2 conjugates. Mol Ther 8:99–107

    Article  PubMed  CAS  Google Scholar 

  • Lee TY, Wu HC, Tseng YL, Lin CT (2004) A novel peptide specifically binding to nasopharyngeal carcinoma for targeted drug delivery. Cancer Res 64:8002–8008

    Article  PubMed  CAS  Google Scholar 

  • Leissner P, Legrand V, Schlesinger Y, Hadji DA, van Raaij M, Cusack S, Pavirani A, Mehtali M (2001) Influence of adenoviral fiber mutations on viral encapsidation, infectivity and in vivo tropism. Gene Ther 8:49–57

    Article  PubMed  CAS  Google Scholar 

  • Lieber A, He CY, Meuse L, Schowalter D, Kirillova I, Winther B, Kay MA (1997) The role of Kupffer cell activation and viral gene expression in early liver toxicity after infusion of recombinant adenovirus vectors. J Virol 71:8798–8807

    PubMed  CAS  Google Scholar 

  • Liu Z, Wu K (2008) Peptides homing to tumor vasculature: imaging and therapeutics for cancer. Recent Pat Anticancer Drug Discov 3:202–208

    Article  PubMed  CAS  Google Scholar 

  • Lotti F, Menguzzato E, Rossi C, Naldini L, Ailles L, Mavilio F, Ferrari G (2002) Transcriptional targeting of lentiviral vectors by long terminal repeat enhancer replacement. J Virol 76:3996–4007

    Article  PubMed  CAS  Google Scholar 

  • Magnusson MK, Hong SS, Boulanger P, Lindholm L (2001) Genetic retargeting of adenovirus: novel strategy employing “deknobbing” of the fiber. J Virol 75:7280–7289

    Article  PubMed  CAS  Google Scholar 

  • Magnusson MK, Kraaij R, Leadley RM, De Ridder CM, van Weerden WM, Van Schie KA, Van der Kroeg M, Hoeben RC, Maitland NJ, Lindholm L (2012) A transductionally retargeted adenoviral vector for virotherapy of Her2/neu-expressing prostate cancer. Hum Gene Ther 23:70–82

    Article  PubMed  CAS  Google Scholar 

  • Mazzolini G, Alfaro C, Sangro B, Feijoo E, Ruiz J, Benito A, Tirapu I, Arina A, Sola J, Herraiz M, Lucena F, Olague C, Subtil J, Quiroga J, Herrero I, Sadaba B, Bendandi M, Qian C, Prieto J, Melero I (2005) Intratumoral injection of dendritic cells engineered to secrete interleukin-12 by recombinant adenovirus in patients with metastatic gastrointestinal carcinomas. J Clin Oncol 23:999–1010

    Article  PubMed  CAS  Google Scholar 

  • Mazzucchelli L, Burritt JB, Jesaitis AJ, Nusrat A, Liang TW, Gewirtz AT, Schnell FJ, Parkos CA (1999) Cell-specific peptide binding by human neutrophils. Blood 93:1738–1748

    PubMed  CAS  Google Scholar 

  • McBride WH (2012) Integration of adenovirus thymidine kinase suicide-gene therapy with surgery and radiation therapy for malignant glioma. Future Oncol 8:17–20

    Article  PubMed  CAS  Google Scholar 

  • Mercier GT, Campbell JA, Chappell JD, Stehle T, Dermody TS, Barry MA (2004) A chimeric adenovirus vector encoding reovirus attachment protein sigma1 targets cells expressing junctional adhesion molecule 1. Proc Natl Acad Sci USA 101:6188–6193

    Article  PubMed  CAS  Google Scholar 

  • Michael SI, Hong JS, Curiel DT, Engler JA (1995) Addition of a short peptide ligand to the adenovirus fiber protein. Gene Ther 2:660–668

    PubMed  CAS  Google Scholar 

  • Miller CR, Buchsbaum DJ, Reynolds PN, Douglas JT, Gillespie GY, Mayo MS, Raben D, Curiel DT (1998) Differential susceptibility of primary and established human glioma cells to adenovirus infection: targeting via the epidermal growth factor receptor achieves fiber receptor-independent gene transfer. Cancer Res 58:5738–5748

    PubMed  CAS  Google Scholar 

  • Mingozzi F, High KA (2011) Immune responses to AAV in clinical trials. Curr Gene Ther 11:321–330

    Article  PubMed  CAS  Google Scholar 

  • Mizuguchi H, Koizumi N, Hosono T, Utoguchi N, Watanabe Y, Kay MA, Hayakawa T (2001) A simplified system for constructing recombinant adenoviral vectors containing heterologous peptides in the HI loop of their fiber knob. Gene Ther 8:730–735

    Article  PubMed  CAS  Google Scholar 

  • Mizuguchi H, Koizumi N, Hosono T, Ishii-Watabe A, Uchida E, Utoguchi N, Watanabe Y, Hayakawa T (2002) CAR- or alphav integrin-binding ablated adenovirus vectors, but not fiber-modified vectors containing RGD peptide, do not change the systemic gene transfer properties in mice. Gene Ther 9:769–776

    Article  PubMed  CAS  Google Scholar 

  • Mok H, Palmer DJ, Ng P, Barry MA (2005) Evaluation of polyethylene glycol modification of first-generation and helper-dependent adenoviral vectors to reduce innate immune responses. Mol Ther 11:66–79

    Article  PubMed  CAS  Google Scholar 

  • Morgenstern PF, Marongiu R, Musatov SA, Kaplitt MG (2011) Adeno-associated viral gene delivery in neurodegenerative disease. Method Mol Biol 793:443–455

    Article  CAS  Google Scholar 

  • Müller FJ, Snyder EY, Loring JF (2006) Gene therapy: can neural stem cells deliver? Nat Rev Neurosci 7:75–84

    Article  PubMed  CAS  Google Scholar 

  • Mulvihill S, Warren R, Venook A, Adler A, Randlev B, Heise C, Kirn D (2001) Safety and feasibility of injection with an E1B-55 kDa gene-deleted, replication-selective adenovirus (ONYX-015) into primary carcinomas of the pancreas: a phase I trial. Gene Ther 8:308–315

    Article  PubMed  CAS  Google Scholar 

  • Muruve DA, Barnes MJ, Stillman IE, Libermann TA (1999) Adenoviral gene therapy leads to rapid induction of multiple chemokines and acute neutrophil-dependent hepatic injury in vivo. Hum Gene Ther 10:965–976

    Article  PubMed  CAS  Google Scholar 

  • Myhre S, Henning P, Granio O, Tylo AS, Nygren PA, Olofsson S, Boulanger P, Lindholm L, Hong SS (2007) Decreased immune reactivity towards a knobless, affibody-targeted adenovirus type 5 vector. Gene Ther 14:376–381

    Article  PubMed  CAS  Google Scholar 

  • Myhre S, Henning P, Friedman M, Stahl S, Lindholm L, Magnusson MK (2009) Re-targeted adenovirus vectors with dual specificity; binding specificities conferred by two different Affibody molecules in the fiber. Gene Ther 16:252–261

    Article  PubMed  CAS  Google Scholar 

  • Nakamura T, Sato K, Hamada H (2003) Reduction of natural adenovirus tropism to the liver by both ablation of fiber-coxsackievirus and adenovirus receptor interaction and use of replaceable short fiber. J Virol 77:2512–2521

    Article  PubMed  CAS  Google Scholar 

  • Nemunaitis J (2011) Head and neck cancer: response to p53-based therapeutics. Head Neck 33:131–134

    Article  PubMed  Google Scholar 

  • Nettelbeck DM, Miller DW, Jerome V, Zuzarte M, Watkins SJ, Hawkins RE, Müller R, Kontermann RE (2001) Targeting of adenovirus to endothelial cells by a bispecific single-chain diabody directed against the adenovirus fiber knob domain and human endoglin (CD105). Mol Ther 3:882–891

    Article  PubMed  CAS  Google Scholar 

  • Nettelbeck DM, Rivera AA, Kupsch J, Dieckmann D, Douglas JT, Kontermann RE, Alemany R, Curiel DT (2004) Retargeting of adenoviral infection to melanoma: combining genetic ablation of native tropism with a recombinant bispecific single-chain diabody (scDb) adapter that binds to fiber knob and HMWMAA. Int J Cancer 108:136–145

    Article  PubMed  CAS  Google Scholar 

  • Nicklin SA, White SJ, Watkins SJ, Hawkins RE, Baker AH (2000) Selective targeting of gene transfer to vascular endothelial cells by use of peptides isolated by phage display. Circulation 102:231–237

    Article  PubMed  CAS  Google Scholar 

  • Nicklin SA, Reynolds PN, Brosnan MJ, White SJ, Curiel DT, Dominiczak AF, Baker AH (2001a) Analysis of cell-specific promoters for viral gene therapy targeted at the vascular endothelium. Hypertension 38:65–70

    Article  PubMed  CAS  Google Scholar 

  • Nicklin SA, Von Seggern DJ, Work LM, Pek DC, Dominiczak AF, Nemerow GR, Baker AH (2001b) Ablating adenovirus type 5 fiber-CAR binding and HI loop insertion of the SIGYPLP peptide generate an endothelial cell-selective adenovirus. Mol Ther 4:534–542

    Article  PubMed  CAS  Google Scholar 

  • Nowakowski GS, Dooner MS, Valinski HM, Mihaliak AM, Quesenberry PJ, Becker PS (2004) A specific heptapeptide from a phage display peptide library homes to bone marrow and binds to primitive hematopoietic stem cells. Stem Cells 22:1030–1038

    Article  PubMed  CAS  Google Scholar 

  • Odermatt A, Audige A, Frick C, Vogt B, Frey BM, Frey FJ, Mazzucchelli L (2001) Identification of receptor ligands by screening phage-display peptide libraries ex vivo on microdissected kidney tubules. J Am Soc Nephrol 12:308–316

    PubMed  CAS  Google Scholar 

  • Ogawara K, Rots MG, Kok RJ, Moorlag HE, Van Loenen AM, Meijer DK, Haisma HJ, Molema G (2004) A novel strategy to modify adenovirus tropism and enhance transgene delivery to activated vascular endothelial cells in vitro and in vivo. Hum Gene Ther 15:433–443

    Article  PubMed  CAS  Google Scholar 

  • O’Riordan CR, Lachapelle A, Delgado C, Parkes V, Wadsworth SC, Smith AE, Francis GE (1999) PEGylation of adenovirus with retention of infectivity and protection from neutralizing antibody in vitro and in vivo. Hum Gene Ther 10:1349–1358

    Article  PubMed  Google Scholar 

  • Ortolano S, Spuch C, Navarro C (2012) Present and future of adeno associated virus based gene therapy approaches. Recent Pat Endocr Metab Immune Drug Discov 6:47–66

    Article  PubMed  CAS  Google Scholar 

  • Pajusola K, Gruchala M, Joch H, Lüscher TF, Yla-Herttuala S, Büeler H (2002) Cell-type-specific characteristics modulate the transduction efficiency of adeno-associated virus type 2 and restrain infection of endothelial cells. J Virol 76:11530–11540

    Article  PubMed  CAS  Google Scholar 

  • Palmer TD, Takahashi J, Gage FH (1997) The adult rat hippocampus contains primordial neural stem cells. Mol Cell Neurosci 8:389–404

    Article  PubMed  CAS  Google Scholar 

  • Palmer TD, Markakis EA, Willhoite AR, Safar F, Gage FH (1999) Fibroblast growth factor-2 activates a latent neurogenic program in neural stem cells from diverse regions of the adult CNS. J Neurosci 19:8487–8497

    PubMed  CAS  Google Scholar 

  • Parato KA, Senger D, Forsyth PA, Bell JC (2005) Recent progress in the battle between oncolytic viruses and tumours. Nat Rev Cancer 5:965–976

    Article  PubMed  CAS  Google Scholar 

  • Parent JM, Valentin VV, Lowenstein DH (2002) Prolonged seizures increase proliferating neuroblasts in the adult rat subventricular zone-olfactory bulb pathway. J Neurosci 22:3174–3188

    PubMed  CAS  Google Scholar 

  • Parker JN, Bauer DF, Cody JJ, Markert JM (2009) Oncolytic viral therapy of malignant glioma. Neurotherapeutics 6:558–569

    Article  PubMed  CAS  Google Scholar 

  • Parks RJ (2000) Improvements in adenoviral vector technology: overcoming barriers for gene therapy. Clin Genet 58:1–11

    Article  PubMed  CAS  Google Scholar 

  • Pasqualini R, Ruoslahti E (1996) Organ targeting in vivo using phage display peptide libraries. Nature 380:364–366

    Article  PubMed  CAS  Google Scholar 

  • Pasqualini R, Koivunen E, Ruoslahti E (1997) Alpha v integrins as receptors for tumor targeting by circulating ligands. Nat Biotechnol 15:542–546

    Article  PubMed  CAS  Google Scholar 

  • Pasqualini R, Koivunen E, Kain R, Lahdenranta J, Sakamoto M, Stryhn A, Ashmun RA, Shapiro LH, Arap W, Ruoslahti E (2000) Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis. Cancer Res 60:722–727

    PubMed  CAS  Google Scholar 

  • Patil SD, Rhodes DG, Burgess DJ (2005) DNA-based therapeutics and DNA delivery systems: a comprehensive review. AAPS J 7:E61–E77

    Article  PubMed  CAS  Google Scholar 

  • Pearson S, Jia H, Kandachi K (2004) China approves first gene therapy. Nat Biotechnol 22:3–4

    Article  PubMed  CAS  Google Scholar 

  • Peng Z (2005) Current status of gendicine in China: recombinant human Ad-p53 agent for treatment of cancers. Hum Gene Ther 16:1016–1027

    Article  PubMed  CAS  Google Scholar 

  • Peng KW, Russell SJ (1999) Viral vector targeting. Curr Opin Biotechnol 10:454–457

    Article  PubMed  CAS  Google Scholar 

  • Preuss MA, Curiel DT (2007) Gene therapy: science fiction or reality? South Med J 100:101–104

    Article  PubMed  Google Scholar 

  • Qiu J, Handa A, Kirby M, Brown KE (2000) The interaction of heparin sulfate and adeno-associated virus 2. Virology 269:137–147

    Article  PubMed  CAS  Google Scholar 

  • Rafii S, Avecilla ST, Jin DK (2003) Tumor vasculature address book: identification of stage-specific tumor vessel zip codes by phage display. Cancer Cell 4:331–333

    Article  PubMed  CAS  Google Scholar 

  • Rajotte D, Arap W, Hagedorn M, Koivunen E, Pasqualini R, Ruoslahti E (1998) Molecular heterogeneity of the vascular endothelium revealed by in vivo phage display. J Clin Invest 102:430–437

    Article  PubMed  CAS  Google Scholar 

  • Rancourt C, Rogers BE, Sosnowski BA, Wang M, Piche A, Pierce GF, Alvarez RD, Siegal GP, Douglas JT, Curiel DT (1998) Basic fibroblast growth factor enhancement of adenovirus-mediated delivery of the herpes simplex virus thymidine kinase gene results in augmented therapeutic benefit in a murine model of ovarian cancer. Clin Cancer Res 4:2455–2461

    PubMed  CAS  Google Scholar 

  • Ravera MW, Carcamo J, Brissette R, Alam-Moghe A, Dedova O, Cheng W, Hsiao KC, Klebanov D, Shen H, Tang P, Blume A, Mandecki W (1998) Identification of an allosteric binding site on the transcription factor p53 using a phage-displayed peptide library. Oncogene 16:1993–1999

    Article  PubMed  CAS  Google Scholar 

  • Rein DT, Breidenbach M, Wu H, Han T, Haviv YS, Wang M, Kirby TO, Kawakami Y, Dall P, Alvarez RD, Curiel DT (2004) Gene transfer to cervical cancer with fiber-modified adenoviruses. Int J Cancer 111:698–704

    Article  PubMed  CAS  Google Scholar 

  • Reynolds BA, Rietze RL (2005) Neural stem cells and neurospheres–re-evaluating the relationship. Nat Methods 2:333–336

    Article  PubMed  CAS  Google Scholar 

  • Reynolds PN, Zinn KR, Gavrilyuk VD, Balyasnikova IV, Rogers BE, Buchsbaum DJ, Wang MH, Miletich DJ, Grizzle WE, Douglas JT, Danilov SM, Curiel DT (2000) A targetable, injectable adenoviral vector for selective gene delivery to pulmonary endothelium in vivo. Mol Ther 2:562–578

    Article  PubMed  CAS  Google Scholar 

  • Reynolds PN, Holmes MD, Adachi Y, Kaliberova L, Curiel DT (2001a) A novel system for mitigation of ectopic transgene expression induced by adenoviral vectors. Gene Ther 8:1271–1275

    Article  PubMed  CAS  Google Scholar 

  • Reynolds PN, Nicklin SA, Kaliberova L, Boatman BG, Grizzle WE, Balyasnikova IV, Baker AH, Danilov SM, Curiel DT (2001b) Combined transductional and transcriptional targeting improves the specificity of transgene expression in vivo. Nat Biotechnol 19:838–842

    Article  PubMed  CAS  Google Scholar 

  • Roelvink PW, Lizonova A, Lee JG, Li Y, Bergelson JM, Finberg RW, Brough DE, Kovesdi I, Wickham TJ (1998) The coxsackievirus-adenovirus receptor protein can function as a cellular attachment protein for adenovirus serotypes from subgroups A, C, D, E, and F. J Virol 72:7909–7915

    PubMed  CAS  Google Scholar 

  • Roelvink PW, Mi Lee G, Einfeld DA, Kovesdi I, Wickham TJ (1999) Identification of a conserved receptor-binding site on the fiber proteins of CAR-recognizing adenoviridae. Science 286:1568–1571

    Article  PubMed  CAS  Google Scholar 

  • Romanczuk H, Galer CE, Zabner J, Barsomian G, Wadsworth SC, O’Riordan CR (1999) Modification of an adenoviral vector with biologically selected peptides: a novel strategy for gene delivery to cells of choice. Hum Gene Ther 10:2615–2626

    Article  PubMed  CAS  Google Scholar 

  • Ruoslahti E, Rajotte D (2000) An address system in the vasculature of normal tissues and tumors. Annu Rev Immunol 18:813–827

    Article  PubMed  CAS  Google Scholar 

  • Ryu EJ, Angelastro JM, Greene LA (2005) Analysis of gene expression changes in a cellular model of Parkinson disease. Neurobiol Dis 18:54–74

    Article  PubMed  CAS  Google Scholar 

  • Sangro B, Mazzolini G, Ruiz J, Herraiz M, Quiroga J, Herrero I, Benito A, Larrache J, Pueyo J, Subtil JC, Olague C, Sola J, Sadaba B, Lacasa C, Melero I, Qian C, Prieto J (2004) Phase I trial of intratumoral injection of an adenovirus encoding interleukin-12 for advanced digestive tumors. J Clin Oncol 22:1389–1397

    Article  PubMed  CAS  Google Scholar 

  • Savontaus MJ, Sauter BV, Huang TG, Woo SL (2002) Transcriptional targeting of conditionally replicating adenovirus to dividing endothelial cells. Gene Ther 9:972–979

    Article  PubMed  CAS  Google Scholar 

  • Schambach A, Galla M, Modlich U, Will E, Chandra S, Reeves L, Colbert M, Williams DA, von Kalle C, Baum C (2006) Lentiviral vectors pseudotyped with murine ecotropic envelope: increased biosafety and convenience in preclinical research. Exp Hematol 34:588–592

    Article  PubMed  CAS  Google Scholar 

  • Scheel JR, Ray J, Gage FH, Barlow C (2005) Quantitative analysis of gene expression in living adult neural stem cells by gene trapping. Nat Methods 2:363–370

    Article  PubMed  CAS  Google Scholar 

  • Schmidt A, Böckmann M, Stoll A, Racek T, Pützer BM (2005) Analysis of adenovirus gene transfer into adult neural stem cells. Virus Res 114:45–53

    Article  PubMed  CAS  Google Scholar 

  • Schmidt A, Haas SJ, Hildebrandt S, Scheibe J, Eckhoff B, Racek T, Kempermann G, Wree A, Pützer BM (2007) Selective targeting of adenoviral vectors to neural precursor cells in the hippocampus of adult mice: new prospects for in situ gene therapy. Stem Cells 25:2910–2918

    Article  PubMed  CAS  Google Scholar 

  • Schmidt A, Eipel C, Fürst K, Sommer N, Pahnke J, Pützer BM (2011) Evaluation of systemic targeting of RET oncogene-based MTC with tumor-selective peptide-tagged Ad vectors in clinical mouse models. Gene Ther 18:418–423

    Article  PubMed  CAS  Google Scholar 

  • Scott JK, Smith GP (1990) Searching for peptide ligands with an epitope library. Science 249:386–390

    Article  PubMed  CAS  Google Scholar 

  • Senac JS, Doronin K, Russell SJ, Jelinek DF, Greipp PR, Barry MA (2010) Infection and killing of multiple myeloma by adenoviruses. Hum Gene Ther 21:179–190

    Article  PubMed  CAS  Google Scholar 

  • Senzer N, Mani S, Rosemurgy A, Nemunaitis J, Cunningham C, Guha C, Bayol N, Gillen M, Chu K, Rasmussen C, Rasmussen H, Kufe D, Weichselbaum R, Hanna N (2004) TNFerade biologic, an adenovector with a radiation-inducible promoter, carrying the human tumor necrosis factor alpha gene: a phase I study in patients with solid tumors. J Clin Oncol 22:592–601

    Article  PubMed  CAS  Google Scholar 

  • Seow Y, Wood MJ (2009) Biological gene delivery vehicles: beyond viral vectors. Mol Ther 17:767–777

    Article  PubMed  CAS  Google Scholar 

  • Seung-Min L, Gil-Suk Y, Eun-Sang Y, Tae-Gyun K, In-San K, Byung-Heon L (2009) Application of phage display to discovery of tumor-specific homing peptides: developing strategies for therapy and molecular imaging of cancer. Method Mol Biol 512:355–363

    Article  CAS  Google Scholar 

  • Shayakhmetov DM, Lieber A (2000) Dependence of adenovirus infectivity on length of the fiber shaft domain. J Virol 74:10274–10286

    Article  PubMed  CAS  Google Scholar 

  • Shayakhmetov DM, Li ZY, Ni S, Lieber A (2004) Analysis of adenovirus sequestration in the liver, transduction of hepatic cells, and innate toxicity after injection of fiber-modified vectors. J Virol 78:5368–5381

    Article  PubMed  CAS  Google Scholar 

  • Shichinohe T, Bochner BH, Mizutani K, Nishida M, Hegerich-Gilliam S, Naldini L, Kasahara N (2001) Development of lentiviral vectors for antiangiogenic gene delivery. Cancer Gene Ther 8:879–889

    Article  PubMed  CAS  Google Scholar 

  • Shifrin AL, Chirmule N, Gao GP, Wilson JM, Raper SE (2005) Innate immune responses to adenoviral vector-mediated acute pancreatitis. Pancreas 30:122–129

    Article  PubMed  CAS  Google Scholar 

  • Shirakawa T (2009) Clinical trial design for adenoviral gene therapy products. Drug News Perspect 22:140–145

    Article  PubMed  CAS  Google Scholar 

  • Siebzehnrubl FA, Vedam-Mai V, Azari H, Reynolds BA, Deleyrolle LP (2011) Isolation and characterization of adult neural stem cells. Method Mol Biol 750:61–77

    Article  CAS  Google Scholar 

  • Simonelli F, Maguire AM, Testa F, Pierce EA, Mingozzi F, Bennicelli JL, Rossi S, Marshall K, Banfi S, Surace EM, Sun J, Redmond TM, Zhu X, Shindler KS, Ying GS, Ziviello C, Acerra C, Wright JF, McDonnell JW, High KA, Bennett J, Auricchio A (2010) Gene therapy for Leber’s congenital amaurosis is safe and effective through 1.5 years after vector administration. Mol Ther 18:643–650

    Article  PubMed  CAS  Google Scholar 

  • Sinnayah P, Lindley TE, Staber PD, Davidson BL, Cassell MD, Davisson RL (2004) Targeted viral delivery of Cre recombinase induces conditional gene deletion in cardiovascular circuits of the mouse brain. Physiol Genomics 18:25–32

    Article  PubMed  CAS  Google Scholar 

  • Smith T, Idamakanti N, Kylefjord H, Rollence M, King L, Kaloss M, Kaleko M, Stevenson SC (2002) In vivo hepatic adenoviral gene delivery occurs independently of the coxsackievirus-adenovirus receptor. Mol Ther 5:770–779

    Article  PubMed  CAS  Google Scholar 

  • Smith TA, Idamakanti N, Marshall-Neff J, Rollence ML, Wright P, Kaloss M, King L, Mech C, Dinges L, Iverson WO, Sherer AD, Markovits JE, Lyons RM, Kaleko M, Stevenson SC (2003a) Receptor interactions involved in adenoviral-mediated gene delivery after systemic administration in non-human primates. Hum Gene Ther 14:1595–1604

    Article  PubMed  CAS  Google Scholar 

  • Smith TA, Idamakanti N, Rollence ML, Marshall-Neff J, Kim J, Mulgrew K, Nemerow GR, Kaleko M, Stevenson SC (2003b) Adenovirus serotype 5 fiber shaft influences in vivo gene transfer in mice. Hum Gene Ther 14:777–787

    Article  PubMed  CAS  Google Scholar 

  • Sonpavde G, Thompson TC, Jain RK, Ayala GE, Kurosaka S, Edamura K, Tabata K, Ren C, Goltsov AA, Mims MP, Hayes TG, Ittmann MM, Wheeler TM, Gee A, Miles BJ, Kadmon D (2011) GLIPR1 tumor suppressor gene expressed by adenoviral vector as neoadjuvant intraprostatic injection for localized intermediate or high-risk prostate cancer preceding radical prostatectomy. Clin Cancer Res 17:7174–7182

    Article  PubMed  CAS  Google Scholar 

  • Spear MA, Breakefield XO, Beltzer J, Schuback D, Weissleder R, Pardo FS, Ladner R (2001) Isolation, characterization, and recovery of small peptide phage display epitopes selected against viable malignant glioma cells. Cancer Gene Ther 8:506–511

    Article  PubMed  CAS  Google Scholar 

  • Stein L, Roy K, Lei L, Kaushal S (2011) Clinical gene therapy for the treatment of RPE65-associated Leber congenital amaurosis. Expert Opin Biol Ther 11:429–439

    Article  PubMed  CAS  Google Scholar 

  • Steiner B, Wolf S, Kempermann G (2006) Adult neurogenesis and neurodegenerative disease. Regen Med 1:15–28

    Article  PubMed  CAS  Google Scholar 

  • Su JL, Lai KP, Chen CA, Yang CY, Chen PS, Chang CC, Chou CH, Hu CL, Kuo ML, Hsieh CY, Wei LH (2005) A novel peptide specifically binding to interleukin-6 receptor (gp80) inhibits angiogenesis and tumor growth. Cancer Res 65:4827–4835

    Article  PubMed  CAS  Google Scholar 

  • Tamm I, Trepel M, Cardo-Vila M, Sun Y, Welsh K, Cabezas E, Swatterthwait A, Arap W, Reed JC, Pasqualini R (2003) Peptides targeting caspase inhibitors. J Biol Chem 278:14401–14405

    Article  PubMed  CAS  Google Scholar 

  • Tani J, Faustine, Sufian JT (2011) Updates on current advances in gene therapy. West Ind Med J 60:188–194

    Google Scholar 

  • Thomas CE, Edwards P, Wickham TJ, Castro MG, Lowenstein PR (2002) Adenovirus binding to the coxsackievirus and adenovirus receptor or integrins is not required to elicit brain inflammation but is necessary to transduce specific neural cell types. J Virol 76:3452–3460

    Article  PubMed  CAS  Google Scholar 

  • Thomas CE, Ehrhardt A, Kay MA (2003) Progress and problems with the use of viral vectors for gene therapy. Nat Rev Genet 4:346–358

    Article  PubMed  CAS  Google Scholar 

  • Touchefeu Y, Vassaux G, Harrington KJ (2011) Oncolytic viruses in radiation oncology. Radiother Oncol 99:262–270

    Article  PubMed  CAS  Google Scholar 

  • Triozzi PL, Borden EC (2011) VB-111 for cancer. Expert Opin Biol Ther 11:1669–1676

    Article  PubMed  CAS  Google Scholar 

  • Trono D (2000) Lentiviral vectors: turning a deadly foe into a therapeutic agent. Gene Ther 7:20–23

    Article  PubMed  CAS  Google Scholar 

  • van Beusechem VW, Grill J, Mastenbroek DC, Wickham TJ, Roelvink PW, Haisma HJ, Lamfers ML, Dirven CM, Pinedo HM, Gerritsen WR (2002) Efficient and selective gene transfer into primary human brain tumors by using single-chain antibody-targeted adenoviral vectors with native tropism abolished. J Virol 76:2753–2762

    Article  PubMed  CAS  Google Scholar 

  • van Zeeburg HJ, van Beusechem VW, Huizenga A, Haisma HJ, Korokhov N, Gibbs S, Leemans CR, Brakenhoff RH (2010) Adenovirus retargeting to surface expressed antigens on oral mucosa. J Gene Med 12:365–376

    Article  PubMed  CAS  Google Scholar 

  • Vigne E, Dedieu JF, Brie A, Gillardeaux A, Briot D, Benihoud K, Latta-Mahieu M, Saulnier P, Perricaudet M, Yeh P (2003) Genetic manipulations of adenovirus type 5 fiber resulting in liver tropism attenuation. Gene Ther 10:153–162

    Article  PubMed  CAS  Google Scholar 

  • Viru L, Heller G, Lehto T, Parn K, El Andaloussi S, Langel U, Merits A (2011) Novel viral vectors utilizing intron splice-switching to activate genome rescue, expression and replication in targeted cells. Virol J 8:243

    Article  PubMed  CAS  Google Scholar 

  • Volpers C, Kochanek S (2004) Adenoviral vectors for gene transfer and therapy. J Gene Med Suppl 1:S164–S171

    Article  CAS  Google Scholar 

  • Von Seggern DJ, Chiu CY, Fleck SK, Stewart PL, Nemerow GR (1999) A helper-independent adenovirus vector with E1, E3, and fiber deleted: structure and infectivity of fiberless particles. J Virol 73:1601–1608

    Google Scholar 

  • Vroemen M, Weidner N, Blesch A (2005) Loss of gene expression in lentivirus- and retrovirus-transduced neural progenitor cells is correlated to migration and differentiation in the adult spinal cord. Exp Neurol 195:127–139

    Article  PubMed  CAS  Google Scholar 

  • Waehler R, Russell SJ, Curiel DT (2007) Engineering targeted viral vectors for gene therapy. Nat Rev Genet 8:573–587

    Article  PubMed  CAS  Google Scholar 

  • Watkins SJ, Mesyanzhinov VV, Kurochkina LP, Hawkins RE (1997) The ‘adenobody’ approach to viral targeting: specific and enhanced adenoviral gene delivery. Gene Ther 4:1004–1012

    Article  PubMed  CAS  Google Scholar 

  • Wennier S, Li S, McFadden G (2011) Oncolytic virotherapy for pancreatic cancer. Expert Rev Mol Med 13:e18

    Article  PubMed  CAS  Google Scholar 

  • White SJ, Nicklin SA, Sawamura T, Baker AH (2001) Identification of peptides that target the endothelial cell-specific LOX-1 receptor. Hypertension 37:449–455

    Article  PubMed  CAS  Google Scholar 

  • Wickham TJ (2000) Targeting adenovirus. Gene Ther 7:110–114

    Article  PubMed  CAS  Google Scholar 

  • Wickham TJ (2003) Ligand-directed targeting of genes to the site of disease. Nat Med 9:135–139

    Article  PubMed  CAS  Google Scholar 

  • Wickham TJ, Mathias P, Cheresh DA, Nemerow GR (1993) Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment. Cell 73:309–319

    Article  PubMed  CAS  Google Scholar 

  • Wickham TJ, Carrion ME, Kovesdi I (1995) Targeting of adenovirus penton base to new receptors through replacement of its RGD motif with other receptor-specific peptide motifs. Gene Ther 2:750–756

    PubMed  CAS  Google Scholar 

  • Wickham TJ, Roelvink PW, Brough DE, Kovesdi I (1996) Adenovirus targeted to heparan-containing receptors increases its gene delivery efficiency to multiple cell types. Nat Biotechnol 14:1570–1573

    Article  PubMed  CAS  Google Scholar 

  • Wickham TJ, Tzeng E, Shears LL 2nd, Roelvink PW, Li Y, Lee GM, Brough DE, Lizonova A, Kovesdi I (1997) Increased in vitro and in vivo gene transfer by adenovirus vectors containing chimeric fiber proteins. J Virol 71:8221–8229

    PubMed  CAS  Google Scholar 

  • Witlox MA, Lamfers ML, Wuisman PI, Curiel DT, Siegal GP (2007) Evolving gene therapy approaches for osteosarcoma using viral vectors: review. Bone 40:797–812

    Article  PubMed  CAS  Google Scholar 

  • Wonganan P, Croyle MA (2010) PEGylated adenoviruses: from mice to monkeys. Viruses 2:468–502

    Article  PubMed  CAS  Google Scholar 

  • Wonganan P, Clemens CC, Brasky K, Pastore L, Croyle MA (2011) Species differences in the pharmacology and toxicology of PEGylated helper-dependent adenovirus. Mol Pharm 8:78–92

    Article  PubMed  CAS  Google Scholar 

  • Xiong Z, Cheng Z, Zhang X, Patel M, Wu JC, Gambhir SS, Chen X (2006) Imaging chemically modified adenovirus for targeting tumors expressing integrin alphavbeta3 in living mice with mutant herpes simplex virus type 1 thymidine kinase PET reporter gene. J Nucl Med 47:130–139

    PubMed  CAS  Google Scholar 

  • Yao X, Yoshioka Y, Morishige T, Eto Y, Watanabe H, Okada Y, Mizuguchi H, Mukai Y, Okada N, Nakagawa S (2009) Systemic administration of a PEGylated adenovirus vector with a cancer-specific promoter is effective in a mouse model of metastasis. Gene Ther 16:1395–1404

    Article  PubMed  CAS  Google Scholar 

  • Yao XL, Nakagawa S, Gao JQ (2011) Current targeting strategies for adenovirus vectors in cancer gene therapy. Curr Cancer Drug Target 11:810–825

    Article  CAS  Google Scholar 

  • Yoo GH, Moon J, Leblanc M, Lonardo F, Urba S, Kim H, Hanna E, Tsue T, Valentino J, Ensley J, Wolf G (2009) A phase 2 trial of surgery with perioperative INGN 201 (Ad5CMV-p53) gene therapy followed by chemoradiotherapy for advanced, resectable squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, and larynx: report of the Southwest Oncology Group. Arch Otolaryngol Head Neck Surg 135:869–874

    Article  PubMed  Google Scholar 

  • Zhang X, Godbey WT (2006) Viral vectors for gene delivery in tissue engineering. Adv Drug Deliv Rev 58:515–534

    Article  PubMed  CAS  Google Scholar 

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Acknowledgements

The authors thank Marc Steder for preparing illustrations. Work was supported by grants from Bundesministerium für Bildung und Forschung (BMBF), Deutsche Forschungsgemeinschaft (DFG), Exzellenzförderprogramm (EFP) Mecklenburg-Vorpommern, and Medical Faculty of Rostock University (FORUN grant program).

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  1. Department of Vectorology and Experimental Gene Therapy, Biomedical Research Center, Rostock University Medical Center, Schillingallee 69, 18057, Rostock, Germany

    Julia Reetz, Ottmar Herchenröder Ph.D., Anke Schmidt Ph.D. & Brigitte M. Pützer M.D., Ph.D.

  2. Zentrum für Innovationskompetenz (ZIK) plasmatis, INP Greifswald e.V., Felix-Hausdorff-Str. 2, 17489, Greifswald, Germany

    Anke Schmidt Ph.D.

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  1. Julia Reetz
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Correspondence to Brigitte M. Pützer M.D., Ph.D. .

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  1. Klinik und Poliklinik für Herzchirurgie, Universitätsklinikum Rostock, Schillingallee 35, Rostock, 18057, Germany

    Gustav Steinhoff

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Reetz, J., Herchenröder, O., Schmidt, A., Pützer, B.M. (2013). Vector Technology and Cell Targeting: Peptide-Tagged Adenoviral Vectors as a Powerful Tool for Cell Specific Targeting. In: Steinhoff, G. (eds) Regenerative Medicine. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5690-8_19

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