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Hematopoietic Stem Cells

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Regenerative Medicine

Abstract

Hematopoietic stem cells represent the most studied and understood adult stem cell, and have consequently set the trends for the investigation of a wide array of stem cells, while their clinical use for over half a century and ever improving efficacy encourages the view that stem cell therapy will one day be useful in the treatment of a whole host of diseases that involve cellular loss. In this chapter we describe how hematopoietic stem cells can be identified, isolated and characterized, and how important it is to be able to conduct experiments on animal models as well as humans, especially as studies in animals can provide the best, sometimes only, way to test stem cell potential and new protocols for their therapeutic use. The increasing possibilities for bone marrow regenerative medicine raised by the rapid developments in our ability to derive pluripotent stem cells from any individual are discussed, in particular because these are likely to be a very effective source of hematopoietic stem cells for all people requiring them to be replaced, as well as the exciting prospect that they can provide a route for the correction of inherited diseases affecting the blood system.

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  1. Institute of Biomedical Research, College of Medicine and Dental Science, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK

    Mary L. Clarke Ph.D. & Jonathan Frampton B.A., Ph.D.

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  1. Mary L. Clarke Ph.D.
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  2. Jonathan Frampton B.A., Ph.D.
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Correspondence to Jonathan Frampton B.A., Ph.D. .

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  1. Klinik und Poliklinik für Herzchirurgie, Universitätsklinikum Rostock, Schillingallee 35, Rostock, 18057, Germany

    Gustav Steinhoff

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Clarke, M.L., Frampton, J. (2013). Hematopoietic Stem Cells. In: Steinhoff, G. (eds) Regenerative Medicine. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5690-8_10

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