Skip to main content

Spinal Cord Ganglioglioma

  • Chapter
  • First Online:
Book cover Tumors of the Central Nervous System, Volume 10

Part of the book series: Tumors of the Central Nervous System ((TCNS,volume 10))

  • 1321 Accesses

Abstract

Ganglioglioma of the spinal cord is a rare tumor that affects predominately the pediatric population. This type of intramedullary spinal cord neoplasm is generally considered benign, corresponding to WHO grade II. Common presenting symptoms include pain, neurologic deficits, and spinal deformity. Because of the indolent clinical course, risk of recurrence, and relative ineffectiveness of additional treatment modalities, early diagnosis with imaging as well as early surgical intervention are highly recommended. Complete, or near complete, resection usually results in long-term progression-free survival, and improvement of neurological status is achievable despite aggressive surgery. Improved microsurgical techniques, preoperative planning with MRI, and intraoperative neurophysiological monitoring have made a significant impact on the management of all spinal cord tumors including gangliogliomas.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Abbott R, Feldstein N, Wisoff JH, Epstein FJ (1992) Osteoplastic laminotomy in children. Pediatr Neurosurg 18:153–156

    Article  PubMed  CAS  Google Scholar 

  • Albright L, Byrd RP (1980) Ganglioglioma of entire spinal cord. Childs Brain 6:274–280

    PubMed  CAS  Google Scholar 

  • Allen JC, Aviner S, Yates AJ, Boyett JM, Cherlow JM, Turski PA, Epstein F, Finlay JL (1998) Treatment of high-grade spinal cord astrocytoma of childhood with ‘8-in-1’ chemotherapy and radiotherapy: a pilot study of CCG-945. Children’s Cancer Group. J Neurosurg 88:215–220

    Article  PubMed  CAS  Google Scholar 

  • Chamoun RB, Alaraj AM, Kutoubi AOA, Abboud RR, Haddad GF (2006) Role of temozolamide in spinal cord low grade astrocytomas: results in two pediatric patients. Acta Neurochir (Wien) 148:175–180

    Article  CAS  Google Scholar 

  • Constantini S, Houten J, Miller DC, Freed D, Ozek MM, Rorke LB, Allen JC, Epstein FJ (1996) Intramedullary spinal cord tumors in children under the age of 3 years. J Neurosurg 85:1036–1043

    Article  PubMed  CAS  Google Scholar 

  • Constantini S, Miller DC, Allen JC, Rorke LB, Freed D, Epstein FJ (2000) Radical excision of intramedullary spinal cord tumors: surgical morbidity and long-term follow-up evaluation in 164 children and young adults. J Neurosurg 93:183–193

    Article  PubMed  CAS  Google Scholar 

  • Elsberg CA, Beer E (1911) The operability of intramedullary tumors of the spinal cord. A report of two operations with remarks upon the extrusion of intraspinal tumors. Am J Med Sci 142:636–647

    Article  Google Scholar 

  • Epstein FJ, Farmer JP (1990) Pediatric spinal cord tumor surgery. Neurosurg Clin N Am 1:569–590

    PubMed  CAS  Google Scholar 

  • Garrido E, Becker LF, Hoffman HJ, Hendrick EB, Humphreys R (1978) Gangliogliomas in children. A clinicopathological study. Childs Brain 4:339–346

    PubMed  CAS  Google Scholar 

  • Hamburger C, Buttner A, Weis S (1997) Ganglioglioma of the spinal cord. Report of two rare cases and review of the literature. Neurosurgery 41:1410–1415

    Article  PubMed  CAS  Google Scholar 

  • Henry JM, Heffner RR, Earle KM (1978) Gangliogliomas of CNS: a clinicopathological study of 50 cases. J Neuropathol Exp Neurol 37:626 (Abstract)

    Google Scholar 

  • Jallo GI, Danish S, Velasquez L, Epstein F (2001) Intramedullary low-grade astrocytomas: long-term outcome following radical surgery. J Neurooncol 53:61–66

    Article  PubMed  CAS  Google Scholar 

  • Jallo GI, Freed D, Epstein FJ (2004) Spinal cord ­gangliogliomas: a review of 56 patients. J Neurooncol 68:71–77

    Article  PubMed  Google Scholar 

  • Katzman H, Waug T, Berdon W (1969) Skeletal changes following irradiation of childhood tumors. J Bone Joint Surg Am 51:825–842

    PubMed  CAS  Google Scholar 

  • Kiwak KJ, Deray MJ, Shields WD (1983) Torticollis in three children with syringomyelia and spinal cord tumor. Neurology 33:946–948

    Article  PubMed  CAS  Google Scholar 

  • Kothbauer KF (2007) Neurosurgical management of intramedullary spinal cord tumors. Pediatr Neurosurg 43:222–235

    Article  PubMed  Google Scholar 

  • Kothbauer KF, Deletis V, Epstein FJ (1998) Motor evoked potential monitoring for intramedullary spinal cord tumor surgery: correlation of clinical and neurophysiological data in a series of 100 consecutive procedures. Neurosurg Focus 4:article 1

    Google Scholar 

  • Lang FF, Epstein FJ, Ransohoff J, Allen JC, Wisoff J, Abbott IR, Miller DC (1993) Central nervous system gangliogliomas. Part 2. Clinical outcome. J Neurosurg 79:867–873

    Article  PubMed  CAS  Google Scholar 

  • Lantos PL, Vandenberg SR, Kleihues P (1997) Tumors of the nervous system. Neuronal and neuronal-glial tumors. Greenfield’s Neuropathol 2:654–677

    Google Scholar 

  • Lee JC, Glasauer FE (1968) Ganglioglioma: light and electron microscopic study. Neurochirurgia 11:160–169

    PubMed  CAS  Google Scholar 

  • Lotfinia I, Vahedi P (2008) Intramedullary cervical spinal cord ganglioglioma, review of the literature and therapeutic controversies. Spinal Cord 47:87–90

    Article  PubMed  Google Scholar 

  • Mayfield JK, Riseborough EJ, Jaffe N, Nehme AME (1981) Spinal deformity in children treated for neuroblastoma. J Bone Joint Surg Am 63:183–193

    PubMed  CAS  Google Scholar 

  • McCormick PC, Torres R, Post KD, Stein B (1990) Intramedullary ependymoma of the spinal cord. J Neurosurg 72:523–532

    Article  PubMed  CAS  Google Scholar 

  • Miller DC, Koslow M, Budzilovich GN, Zagzag D (1990) Synaptophysin: a sensitive and specific marker for ganglion cells in central nervous system neoplasms. Hum Pathol 21:271–276

    Article  PubMed  CAS  Google Scholar 

  • Minehan KJ, Shaw EG, Scheithauer BW, Davis DL, Onofrio BM (1995) Spinal cord astrocytoma: pathological and treatment considerations. J Neurosurg 83:590–595

    Article  PubMed  CAS  Google Scholar 

  • Morota N, Deletis V, Constantini S, Kofler M, Cohen H, Epstein FJ (1997) The role of motor evoked potentials during surgery for intramedullary spinal cord tumors. Neurosurgery 41:1327–1336

    Article  PubMed  CAS  Google Scholar 

  • Otsubo H, Hoffman HJ, Humphreys R, Hendrick EB, Darak JM, Hwang PA, Beckere LE, Chaung SH (1992) Detection and management of gangliogliomas in children. Surg Neurol 38:371–378

    Article  PubMed  CAS  Google Scholar 

  • Park SH, Chi JG, Cho BK, Wang KC (1993) Spinal cord ganglioglioma in childhood. Pathol Res Pract 189:189–196

    Article  PubMed  CAS  Google Scholar 

  • Park CK, Chung CK, Choe GY, Wang KC, Cho BK, Kim HJ (2000) Intramedullary spinal cord ganglioglioma: a report of five cases. Acta Neurochir (Wien) 142:547–552

    Article  CAS  Google Scholar 

  • Raimondi AJ, Gutierrez FA, Di Rocco C (1976) Laminotomy and total reconstruction of the posterior spinal arch for spinal canal surgery in childhood. J Neurosurg 45:555–560

    Article  PubMed  CAS  Google Scholar 

  • Rifkinson-Mann S, Wisoff JH, Epstein FJ (1990) The association of hydrocephalus with intra- medullary spinal cord tumors: a series of 25 patients. Neurosurgery 27:749–754

    Article  PubMed  CAS  Google Scholar 

  • Rodewald L, Miller D, Sciorra L, Barabas G, Lee ML (1987) Central nervous system neoplasm in a young man with martin-bell syndrome: fra (X)-XLMR. Am J Med Genet 26:7–12

    Article  PubMed  CAS  Google Scholar 

  • Sandalcioglu IE, Gasser T, Asgari S, Lazorisak A, Engelhorn T, Egelhof T, Stolke D, Wiedemayer H (2005) Functional outcome after surgical treatment of intramedullary spinal cord tumors: experience with 78 patients. Spinal Cord 43:34–41

    Article  PubMed  CAS  Google Scholar 

  • Satyarthee GD, Mehta VS, Vaishya S (2003) Ganglioglioma of the spinal cord: report of two cases and review of literature. J Clin Neurosci 11:199–203

    Article  Google Scholar 

  • Shrivastava RK, Epstein FJ, Perin NI, Post KD, Jallo GI (2005) Intramedullary spinal cord tumors in patients older than 50 years of age: management and outcome analysis. J Neurosurg Spine 2:249–255

    Article  PubMed  Google Scholar 

  • Taniguchi M, Cedzich C, Schramm J (1993) Modification of cortical stimulation for motor evoked potentials under general anesthesia: technical description. Neurosurgery 32:219–226

    Article  PubMed  CAS  Google Scholar 

  • Ulutin HC, Onguru O, Pak Y (2002) Postoperative radiotherapy for ganglioglioma: report of three cases and review of the literature. Minim Invasive Neurosurg 45:224–227

    Article  PubMed  CAS  Google Scholar 

  • von Eiselsberg A, Marburg O (1917) Zur Frage der Operabilitat intramedullarer Ruckenmarkstumoren. Arch Psychiatr Nervenkrankh 59:453–461

    Article  Google Scholar 

  • Wood EH, Berne AS, Taveras JM (1954) The value of radiation therapy in the management of intrinsic tumors of the spinal cord. Radiology 63:11–24

    PubMed  CAS  Google Scholar 

  • Yasuoka S, Peterson HA, MacCarty CS (1982) Incidence of spinal column deformity after multilevel laminectomy in children and adults. J Neurosurg 57:441–445

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to George Jallo .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Hwang, L., Tok, S., Jallo, G. (2013). Spinal Cord Ganglioglioma. In: Hayat, M. (eds) Tumors of the Central Nervous System, Volume 10. Tumors of the Central Nervous System, vol 10. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5681-6_27

Download citation

  • DOI: https://doi.org/10.1007/978-94-007-5681-6_27

  • Published:

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-007-5680-9

  • Online ISBN: 978-94-007-5681-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics