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Pituitary Tumor Cells: Role of PKCα, PKCδ and PKCε Expression

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Tumors of the Central Nervous System, Volume 10

Part of the book series: Tumors of the Central Nervous System ((TCNS,volume 10))

Abstract

The PKC family is involved in a wide variety of cellular processes such as proliferation, senescence and cell death, which are determined by the specific subcellular targeting of these kinases.

In adenomatous pituitary cells, it has been observed that the enzyme activity and expression of PKCs were higher than in normal pituitary. The isozymes PKCα and PKCε are usually involved in tumorigenesis and are the most expressed in human pituitary adenomas. The specific PKCα and PKCε activation is closely associated with the tumoral pituitary cell proliferation and cell cycle progression through the ERK 1/2 pathway. By contrast, PKCδ has been shown to mediate anti-proliferative and apoptotic signals. In the regression of pituitary tumors triggered by bromocriptine the PKCδ /p38 pathway is involved in a non-­apoptotic mechanism identified as parapoptosis.

Each individual PKC isozyme is undoubtedly an attractive target for therapeutic intervention, given its role in survival and cell death in pituitary tumors, processes that contribute to the onset and progression of the tumorigenesis. The combination of specific inhibitors of PKC and the “upstream-downstream” kinases of the signalling pathways with conventional antitumoral drugs could lead to a better tolerance and effectiveness in the regression of pituitary tumors.

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Authors and Affiliations

  1. Centro de Microscopía Electrónica, Facultad de Ciencias Médicas, Universidad de Córdoba, 5000, Córdoba, Argentina

    Juan Pablo Petiti & Alicia Inés Torres

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  1. Juan Pablo Petiti
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  2. Alicia Inés Torres
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Correspondence to Juan Pablo Petiti .

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  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

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Petiti, J.P., Torres, A.I. (2013). Pituitary Tumor Cells: Role of PKCα, PKCδ and PKCε Expression. In: Hayat, M. (eds) Tumors of the Central Nervous System, Volume 10. Tumors of the Central Nervous System, vol 10. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5681-6_17

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  • DOI: https://doi.org/10.1007/978-94-007-5681-6_17

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