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Pituitary Adenoma and Craniopharyngioma: An Overview

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Tumors of the Central Nervous System, Volume 10

Part of the book series: Tumors of the Central Nervous System ((TCNS,volume 10))

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Abstract

This chapter discusses the pathologic features of pituitary adenoma and craniopharyngioma, the two most common and problematic neoplasms of the region of sella turcica. Pituitary adenoma, even when it is small, can present with very diverse clinical and pathological findings owing to its variety of cell types and its location. An increasing number of subtypes are being recognized based on histological and immunohistochemical features. Valuable data can be obtained from the pathologic evaluation in terms of biologic aggressiveness of the adenoma, and its further characterization as invasive and/or atypical. Craniopharyngioma is a low grade neoplasm that can be quite problematic due to its locally invasive nature and recurrences. Histologic subtypes, namely adamantinomatous and papillary, are reviewed; their pathologic features and prognoses are discussed. Finally, the interesting coexistence of these two neoplasms is discussed briefly.

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References

  • Adamson TE, Wiestler OD, Kleihues P, Yasargil MG (1990) Correlation of clinical and pathological features in surgically treated craniopharyngiomas. J Neurosurg 73:12–17

    Article  PubMed  CAS  Google Scholar 

  • Asa SL (1998) Tumors of the pituitary gland. Atlas of tumor pathology, 3rd Series, Fascicle 22, Series Editor Rosai J, AFIP, Washington, DC, pp 149–150

    Google Scholar 

  • Asa SL, Kovacs K, Bilbao JM (1983) The pars tuberalis of the human pituitary: a histologic, immunohistochemical, ultrastructural and immunoelectron microscopic analysis. Virchows Arch A Pathol Anat Histopathol 399:49–59

    Article  PubMed  CAS  Google Scholar 

  • Bunin GR, Surawicz TS, Witman PA, Preston-Martin S, Davis F, Bruner JM (1998) A descriptive epidemiology of craniopharyngioma. J Neurosurg 89:547–551

    Article  PubMed  CAS  Google Scholar 

  • Buslei R, Nolde M, Hofmann B, Meissner S, Eyupoglu IY, Siebzehnrubl F, Hahnen E, Kreutzer J, Fahlbusch R (2005) Common mutations of beta-catenin in adamantinomatous craniopharyngioma but not in other tumours originating from the sellar region. Acta Neuropathol 109:589–597

    Article  PubMed  CAS  Google Scholar 

  • Crotty TB, Scheithauer BW, Young WF, Davis DH, Shaw EG, Muller GM, Burger PC (1995) Papillary craniopharyngioma: a clinicopathologic study of 48 cases. J Neurosurg 83:206–214

    Article  PubMed  CAS  Google Scholar 

  • Daly AF, Tichomirowa MA, Beckers A (2009) The epidemiology and genetics of pituitary adenomas. Best Pract Res Clin Endocrinol Metab 23:543–554

    Article  PubMed  CAS  Google Scholar 

  • Frangou EM, Tynan JR, Robinson CA, Ogieglo LM, Vitali AM (2009) Metastatic craniopharyngioma: case report and literature review. Childs Nerv Syst 25:1143–1147

    Article  PubMed  Google Scholar 

  • Ghadially FN (1982) Ultrastructural pathology of the cell and matrix, 2nd edn. Butterworths, London, pp 288–289

    Google Scholar 

  • Gokden M, Mrak RE (2009) Pituitary adenoma with craniopharyngioma component. Human Pathol 40:1189–1193

    Article  Google Scholar 

  • Horvath E, Kovacs K, Singer W, Smyth HS, Killinger DW, Erzin C, Weiss MH (1981) Acidophil stem cell adenoma of the human pituitary: clinicopathologic analysis of 15 cases. Cancer 47:761–771

    Article  PubMed  CAS  Google Scholar 

  • Horvath E, Lloyd RV, Kovacs K, Sano T, Kontogeorgos G, Troillas J, Asa SL (2004) Plurihormonal adenoma. In: DeLellis RA, Lloyd RV, Heitz PU, Eng C (eds) World Health Organization classification of tumours. Pathology and genetics: tumours of endocrine organs. IARC Press, Lyon, p 35

    Google Scholar 

  • Izumoto S, Suzuki T, Kinoshita M, Hashiba T, Kagawa N, Wada K, Fujimoto Y, Hashimoto N, Saitoh Y, Maruno M, Yoshimine T (2005) Immunohistochemical detection of female sex hormone receptors in craniopharyngiomas: correlation with clinical and histologic features. Surg Neurol 63:520–525

    Article  PubMed  Google Scholar 

  • Karavitaki N, Scheithauer BW, Watt J, Ansorge O, Moschopoulos M, Llaguno AV, Wass JAH (2008) Collision lesions of the sella: co-existence of craniopharyngioma with gonadotroph adenoma and of Rathke’s cleft cyst with corticotroph adenoma. Pituitary 11:317–323

    Article  PubMed  CAS  Google Scholar 

  • Kepes JJ, Salyer J, Hiszczynskyj R (1982) Squamous metaplasia following necrosis of the adenohypophysis and of a chromophobe adenoma of the pituitary. Virchows Arch A Pathol Anat Histopathol 395:69–76

    Article  CAS  Google Scholar 

  • Kontogeorgos G, Watson RE Jr, Lindell EP, Barkan AL, Farrell WE, Lloyd RV (2004) Growth hormone producing adenoma. In: DeLellis RA, Lloyd RV, Heitz PU, Eng C (eds) World Health Organization classification of tumours. Pathology and genetics: tumours of endocrine organs. IARC Press, Lyon, pp 14–19

    Google Scholar 

  • Kovacs K, Horvath E, Ryan N, Ezrin C (1980) Null cell adenoma of the human pituitary. Virchows Arch Pathol Anat Histolpathol 387:165–174

    Article  CAS  Google Scholar 

  • Le BH, Towfigi J, Kapadia SB, Lopes MBS (2007) Comparative immunohistochemical assessment of craniopharyngioma and related lesions. Endocr Pathol 18:23–30

    Article  PubMed  CAS  Google Scholar 

  • Lloyd RV, Chandler WF, Kovacs K, Ryan N (1986) Ectopic pituitary adenomas with normal anterior pituitary glands. Am J Surg Pathol 108:546–552

    Article  Google Scholar 

  • Lloyd RV, Kovacs K, Young WF Jr, Farrell WE, Asa SL, Troillas J, Kontogeorgos G, Sano T, Scheithauer BW, Horvath E (2004) Pituitary tumors: introduction. In: DeLellis RA, Lloyd RV, Heitz PU, Eng C (eds) World Health Organization classification of tumours. Pathology and genetics: tumours of endocrine organs. IARC Press, Lyon, pp 10–13

    Google Scholar 

  • Losa M, Vimercati A, Acerno S, Barzaghi RL, Mortini P, Mangili F, Terreni MR, Santambrogio G, Giovanelli M (2004) Correlation between clinical characteristics and proliferative activity in patients with craniopharyngioma. J Neurol Neurosurg Psychiatry 75:889–892

    Article  PubMed  CAS  Google Scholar 

  • Meij BP, Lopes MBS, Ellegala DB, Alden TD, Laws ER Jr (2002) The long-term significance of microscopic dural invasion in 354 patients with pituitary adenomas treated with transsphenoidal surgery. J Neurosurg 96:195–208

    Article  PubMed  Google Scholar 

  • Nishi T, Kuratsu J, Takeshima H, Saito Y, Kochi M, Ushio Y (1999) Prognostic significance of the MIB-1 labeling index for patient with craniopharyngioma. Int J Mol Med 3:157–161

    PubMed  CAS  Google Scholar 

  • Nishioka H, Hirano A, Haraoka J, Nakajima N (2002) Histological changes in the pituitary gland and adenomas following radiotherapy. Neuropathology 22:19–25

    Article  PubMed  Google Scholar 

  • O’Hara BJ, Patau A, Miettinen M (1998) Keratin subsets and monoclonal antibody HBME-1 in chordoma: immunohistochemical differential diagnosis between tumors simulating chordoma. Human Pathol 29:119–126

    Article  Google Scholar 

  • Osamura RY, Sano T, Ezzat S, Asa SL, Barkan AL, Watson RE Jr, Lindell EP (2004) TSH producing adenoma. In: DeLellis RA, Lloyd RV, Heitz PU, Eng C (eds) World Health Organization classification of tumours. Pathology and genetics: tumours of endocrine organs. IARC Press, Lyon, pp 24–25

    Google Scholar 

  • Pernicone PJ, Scheithauer BW, Sebo TJ, Kovacs KT, Horvath E, Yound WF Jr, Lloyd RV, Davis DH, Guthrie BL, Schoene WC (1997) Pituitary carcinoma: a clinicopathologic study of 15 cases. Cancer 79:804–812

    Article  PubMed  CAS  Google Scholar 

  • Rodriguez FJ, Scheithauer BW, Tsunoda S, Kovacs K, Vidal S, Piepgras DG (2007) The spectrum of malignancy in craniopharyngioma. Am J Surg Pathol 31:1020–1028

    Article  PubMed  Google Scholar 

  • Rushing EJ, Giangaspero F, Paulus W, Burger PC (2007) Craniopharyngioma. In: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK (eds) WHO classification of tumours of the central nervous system. IARC Press, Lyon, pp 238–240

    Google Scholar 

  • Saeger W, Horvath E, Kovacs K, Nose V, Farrell WE, Lloyd RV, Watson RE Jr, Lindell EP (2004) Prolactin producing adenoma. In: DeLellis RA, Lloyd RV, Heitz PU, Eng C (eds) World Health Organization classification of tumours. Pathology and genetics: tumours of endocrine organs. IARC Press, Lyon, pp 20–23

    Google Scholar 

  • Saeger W, Ludecke DK, Buchfelder M, Fahlbusch R, Quabbe HJ, Petersenn S (2007) Pathohistological classification of pituitary tumors: 10 years of experience with the German Pituitary Tumor Registry. Eur J Endocrinol 156:203–216

    Article  PubMed  CAS  Google Scholar 

  • Sautner D, Saeger W (1991) Invasiveness of pituitary adenomas. Pathol Res Pract 187:632–636

    Article  PubMed  CAS  Google Scholar 

  • Scheithauer BW, Kovacs KT, Laws ER Jr, Randall RV (1986) Pathology of invasive pituitary tumors with special reference to functional classification. J Neurosurg 65:733–744

    Article  PubMed  CAS  Google Scholar 

  • Scheithauer BW, Laws ER Jr, Kovacs K, Horvath E, Randall RV, Carney JA (1987) Pituitary adenomas of the multiple endocrine neoplasia type 1 syndrome. Semin Diagn Pathol 4:205–211

    PubMed  CAS  Google Scholar 

  • Scheithauer BW, Gaffey TA, Lloyd RV, Sebo TJ, Kovacs KT, Horvath E, Yapicier O, Young WF Jr, Meyer FB, Kuroki T, Riehle DL, Laws ER Jr (2006) Pathobiology of pituitary adenomas and carcinomas. Neurosurgery 59:341–353

    Article  PubMed  Google Scholar 

  • Selman WR, Laws ER Jr, Scheithauer BW, Carpenter SM (1986) The occurrence of dural invasion in pituitary adenomas. J Neurosurg 64:402–407

    Article  PubMed  CAS  Google Scholar 

  • Shin JL, Asa SL, Woodhouse LJ, Smyth HS, Ezzat S (1999) Cystic lesions of the pituitary: clinicopathological features distinguishing craniopharyngioma, Rathke’s cleft cyst, and arachnoid cyst. J Clin Endocrinol Metab 84:3972–3982

    Article  PubMed  CAS  Google Scholar 

  • Surawicz TS, McCarthy BJ, Kupelian V, Jukich PJ, Bruner JM, Davis FG (1999) Descriptive epidemiology of primary brain and CNS tumors: results from the Central Brain Tumor Registry of the United States, 1990–1994. Neuro Oncol 1:14–25

    PubMed  CAS  Google Scholar 

  • Tateyama H, Tada T, Okabe M, Takahashi E, Eimoto T (2001) Different keratin profiles in craniopharyngioma subtypes and ameloblastomas. Pathol Res Pract 197:735–742

    Article  PubMed  CAS  Google Scholar 

  • Tavangar SM, Larijani B, Mahta A, Hosseini SMA, Mehrazine M, Bandarian F (2004) Craniopharyngioma: a clinicopathological study of 141 cases. Endocr Pathol 15:339–344

    Article  PubMed  Google Scholar 

  • Tena-Suck ML, Salinas-Lara C, Arce-Arellano RI, Rembao-Bojorquez D, Morales-Espinosa D, Sotelo J, Arrieta O (2006) Clinicopathological and immunohistochemical characteristics associated to recurrence/regrowth of craniopharyngiomas. Clin Neurol Neurosurg 108:661–669

    Article  PubMed  Google Scholar 

  • Vidal S, Kovacs K, Lloyd RV, Meyer FB, Scheithauer BW (2002) Angiogenesis in patients with craniopharyngiomas: correlation with treatment and outcome. Cancer 94:738–745

    Article  PubMed  Google Scholar 

  • Weiner HL, Wisoff JH, Rosenberg ME, Kupersmith MJ, Cohen H, Zagzag D, Shiminski-Maher T, Flamm ES, Epstein FJ, Miller DC (1994) Craniopharyngiomas: a clinicopathological analysis of factors predictive of recurrence and functional outcome. Neurosurgery 35:1001–1010

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Murat Gokden .

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Gokden, M. (2013). Pituitary Adenoma and Craniopharyngioma: An Overview. In: Hayat, M. (eds) Tumors of the Central Nervous System, Volume 10. Tumors of the Central Nervous System, vol 10. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5681-6_10

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  • DOI: https://doi.org/10.1007/978-94-007-5681-6_10

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