Abstract
The organized neural cells form neural networks for receiving, transducing and integrating neural information. In developing embryo, asymmetrical distribution of specific molecules in neural progenitors contributes to neural polarization and initiates the formation of axons and dendrites on cell cycle exit. Axon is responsible for propagating action potential and triggering an electric or chemical output to the contacted cells. This chapter describes the recent findings about the cellular mechanisms of axon initiation and axon elongation in vitro by using isolated hippocampal neurons and embryonic stem cells-derived motoneurons. In addition, the in vivo studies related to the axon specification are emphasized. Environmental cues for stimulating the axon formation and axon guidance are also introduced.
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Su, HL., Pan, HC. (2013). Embryonic Stem Cell-Derived Motoneurons Develop Aberrant Axonal Sprouting. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 9. Stem Cells and Cancer Stem Cells, vol 9. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5645-8_13
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DOI: https://doi.org/10.1007/978-94-007-5645-8_13
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