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Selected References
Abdel-Salam OM, Szolcsányi J, Mózsik G (1997) Capsaicin and the stomach. A review of experimental and clinical data. J Physiol Paris 91(3–5):151–171
Abdel-Salam OM, Debreceni A, Mózsik G, Szolcsányi J (1999) Capsaicin-sensitive afferent sensory nerves in modulating gastric mucosal defense against noxious agents. J Physiol Paris 93(5):443–454
Abdel-Salam OM, Abdel-Rahman RF, Sleem AA, Farrag AR (2012) Modulation of lipopolysaccharide-induced oxidative stress by capsaicin. Inflammopharmacology 20(4):207–217
Adegoke GO, Allamu AE, Akingbala JO, Akanni AO (1996) Influence of sundrying on the chemical composition, aflatoxin content and fungal counts of two pepper varieties–Capsicum annum and Capsicum frutescens. Plant Foods Hum Nutr 49(2):113–117
Al-Qarawi AA, Adam SE (1999) Effects of red chilli (Capsicum frutescens L.) on rats. Vet Hum Toxicol 41(5):293–295
Al-Qarawi AA, Adam SE (2003) Effect of combination of Capsicum frutescens and Citrullus colocynthis on growth, haematological and pathophysiological parameters of rats. Phytother Res 17(1):92–95
Anandakumar P, Kamaraj S, Jagan S, Ramakrishnan G, Naveenkumar C, Asokkumar S, Devaki T (2009) Capsaicin alleviates the imbalance in xenobiotic metabolizing enzymes and tumor markers during experimental lung tumorigenesis. Mol Cell Biochem 331(1–2):135–143
Anonymous (2007) Final report on the safety assessment of Capsicum annuum extract, Capsicum annuum fruit extract, Capsicum annuum resin, Capsicum annuum fruit powder, Capsicum frutescens fruit, Capsicum frutescens fruit extract, Capsicum frutescens resin, and capsaicin. Int J Toxicol 26(Suppl 1):3–106
Anonymous (2011) Capsaicin patch (Qutenza) for postherpetic neuralgia. Med Lett Drugs Ther 53(1365):42–43
Antonious GF, Jarret RL (2006) Screening Capsicum accessions for capsaicinoids content. J Environ Sci Health B 41(5):717–729
Antonious GF, Kochhar TS, Jarret RL, Snyder JC (2006a) Antioxidants in hot pepper: variation among accessions. J Environ Sci Health B 41(7):1237–1243
Antonious GF, Meyer JE, Snyder JC (2006b) Toxicity and repellency of hot pepper extracts to spider mite, Tetranychus urticae Koch. J Environ Sci Health B 41(8):1383–1391
Backonja MM, Wallace MS, Blonsky ER, Cutler BJ, Malan P Jr, Rauck R, Tobias J, NGX-4010 C116 Study Group (2008) NGX-4010, a high-concentration apsaicin patch, for the treatment of postherpetic neuralgia: a randomised, double-blind study. Lancet Neurol 7(12):1106–1112
Backonja MM, Malan TP, Vanhove GF, Tobias JK, C102/106 Study Group (2010) NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia: a randomized, double-blind, controlled study with an open-label extension. Pain Med 11(4):600–608
Basu S, Srivastava P (2005) Immunological role of neuronal receptor vanilloid receptor 1 expressed on dendritic cells. Proc Natl Acad Sci USA 102(14):5120–5125
Beltran J, Ghosh AK, Basu S (2007) Immunotherapy of tumors with neuroimmune ligand capsaicin. J Immunol 178(5):3260–3264
Belza A, Jessen AB (2005) Bioactive food stimulants of sympathetic activity: effect on 24-h energy expenditure and fat oxidation. Eur J Clin Nutr 59(6):733–741
Belza A, Frandsen E, Kondrup J (2007) Body fat loss achieved by stimulation of thermogenesis by a combination of bioactive food ingredients: a placebo-controlled, double-blind 8-week intervention in obese subjects. Int J Obes (Lond) 31(1):121–130
Bernstein JE, Bickers DR, Dahl MV, Roshal JY (1987) Treatment of chronic postherpetic neuralgia with topical capsaicin. A preliminary study. J Am Acad Dermatol 17(1):93–96
Bernstein JE, Korman NJ, Bickers DR, Dahl MV, Millikan LE (1989) Topical capsaicin treatment of chronic postherpetic neuralgia. J Am Acad Dermatol 21(2 Pt 1):265–270
Bortolotti M, Coccia G, Grossi G (2002) Red pepper and functional dyspepsia. N Engl J Med 346:947–948
Bosland PW (1996) Capsicums: innovative uses of an ancient crop. In: Janick J (ed) Progress in new crops. ASHS Press, Arlington, pp 479–487
Bosland PW, Baral JB (2007) Bhut Jolokia — the world’s hottest known chile pepper is a putative naturally occurring interspecific hybrid. HortSci 42(2):222–224
Bown D (1995) Encyclopaedia of herbs and their uses. Dorling Kindersley, London, 424 pp
Brook RA, Kleinman NL, Choung RS, Melkonian AK, Smeeding JE, Talley NJ (2010) Functional dyspepsia impacts absenteeism and direct and indirect costs. Clin Gastroenterol Hepatol 8(6):498–503
Brown KC, Witte TR, Hardman WE, Luo H, Chen YC, Carpenter AB, Lau JK, Dasgupta P (2010) Capsaicin displays anti-proliferative activity against human small cell lung cancer in cell culture and nude mice models via the E2F pathway. PLoS One 5(4):e10243
Brzozowski T, Konturek SJ, Sliwowski Z, Pytko-Polończyk J, Szlachcic A, Drozdowicz D (1996) Role of capsaicin-sensitive sensory nerves in gastroprotection against acid-independent and acid-dependent ulcerogens. Digestion 57(6):424–432
Burkill IH (1966) A dictionary of the economic products of the Malay Peninsula, Revised reprint, 2 vols. Ministry of Agriculture and Co-operatives, Kuala Lumpur, vol 1 (A–H), pp 1–1240, vol 2 (I–Z), pp 1241–2444
Cameron-Smith D, Colquhoun EQ, Ye JM, Hettiarachchi M, Clark MG (1990) Capsaicin and dihydrocapsaicin stimulate oxygen consumption in the perfused rat hindlimb. Int J Obes 14(3):259–270
Cardeal ZL, Gomes da Silva MDR, Marriott PJ (2006) Comprehensive two-dimensional gas chromatography/mass spectrometric analysis of pepper volatiles. Rapid Commun Mass Spectrom 20:2823–2836
Chai PPK (2006) Medicinal plants of Sarawak. Lee Ming Press, Kuching, 212 pp
Chaiyasit K, Khovidhunkit W, Wittayalertpanya S (2009) Pharmacokinetic and the effect of capsaicin in Capsicum frutescens on decreasing plasma glucose level. J Med Assoc Thai 92(1):108–113
Chaiyata P, Puttadechakum S, Komindr S (2003) Effect of chili pepper (Capsicum frutescens) ingestion on plasma glucose response and metabolic rate in Thai women. J Med Assoc Thai 86(9):854–860
Chanda S, Erexson G, Riach C, Innes D, Stevenson F, Murli H, Bley K (2004) Genotoxicity studies with pure trans-capsaicin. Mutat Res 557(1):85–97
Chevallier A (1996) The encyclopedia of medicinal plants. Dorling Kindersley, London, 336 pp
Chiej R (1984) Encyclopaedia of medicinal plants. MacDonald, London, 447 pp
Chile Head (2011) Varieties database. http://www.g6csy.net/chile/database.html
Ching LS, Mohamed S (2001) Alpha-tocopherol content in 62 edible tropical plants. J Agric Food Chem 49(6):3101–3105
Choi SE, Kim TH, Yi SA, Hwang YC, Hwang WS, Choe SJ, Han SJ, Kim HJ, Kim DJ, Kang Y, Lee KW (2011) Capsaicin attenuates palmitate-induced expression of macrophage inflammatory protein 1 and interleukin 8 by increasing palmitate oxidation and reducing c-Jun activation in THP-1 (human acute monocytic leukemia cell) cells. Nutr Res 31(6):468–478
Cichewicz RH, Thorpe PA (1996) The antimicrobial properties of chile peppers (Capsicum species) and their uses in Mayan medicine. J Ethnopharmacol 52(2):61–70
Cordell GA, Araujo OE (1993) Capsaicin: identification, nomenclature, and pharmacotherapy. Ann Pharmacother 27(3):330–336
D’Arcy WG, Eshbaugh WH (1974) New world peppers (Capsicum - Solanaceae) north of Colombia: a résumé. Baileya 19:93–105
De Lucca AJ, Bland JM, Vigo CB, Cushion M, Selitrennikoff CP, Peter J, Walsh TJ (2002) CAY-I, a fungicidal saponin from Capsicum sp. fruit. Med Mycol 40(2):131–137
De Lucca AJ, Bland JM, Boue S, Vigo CB, Cleveland TE, Walsh TJ (2006a) Synergism of CAY-1 with amphotericin B and itraconazole. Chemotherapy 52(6):285–287
De Lucca AJ, Boue S, Palmgren MS, Maskos K, Cleveland TE (2006b) Fungicidal properties of two saponins from Capsicum frutescens and the relationship of structure and fungicidal activity. Can J Microbiol 52(4):336–342
De AK, Ghosh JJ (1988) Inflammatory effects of acute and chronic capsaicin treatment on rat paw. Phytother Res 2:175–179
Deal CL, Schnitzer TJ, Lipstein E, Seibold JR, Stevens RM, Levy MD, Albert D, Renold F (1991) Treatment of arthritis with topical capsaicin: a double-blind trial. Clin Ther 13(3):383–395
Diepvens K, Westerterp KR, Westerterp-Plantenga MS (2007) Obesity and thermogenesis related to the consumption of caffeine, ephedrine, capsaicin, and green tea. Am J Physiol Regul Integr Comp Physiol 292(1):R77–R85
Eshbaugh WH (1980) The taxonomy of the genus Capsicum (Solanaceae). Phytologia 47(3):153–165
Frerick H, Keitel W, Kuhn U, Schmidt S, Bredehorst A, Kuhlmann M (2003) Topical treatment of chronic low back pain with a capsicum plaster. Pain 106(1–2):59–64
Frucht-Pery J, Feldman ST, Brown SI (1997) The use of capsaicin in herpes zoster ophthalmicus neuralgia. Acta Ophthalmol Scand 75(3):311–313
Führer M, Hammer J (2009) Effect of repeated, long term capsaicin ingestion on intestinal chemo- and mechanosensation in healthy volunteers. Neurogastroenterol Motil 21(5):521–527
Führer M, Vogelsang H, Hammer J (2011) A placebo-controlled trial of an oral capsaicin load in patients with functional dyspepsia. Neurogastroenterol Motil 23(10):918–e397
Gagnier JJ, van Tulder MW, Berman B, Bombardier C (2007) Herbal medicine for low back pain: a Cochrane review. Spine (Phila Pa 1976) 32(1):82–92
Grieve M (1971) A modern herbal. Penguin, 2 vols. Dover publications, Dover/New York, 919 pp
Hammer J, Führer M, Pipal L, Matiasek J (2008) Hypersensitivity for capsaicin in patients with functional dyspepsia. Neurogastroenterol Motil 20(2):125–133
Henry CJ, Emery B (1986) Effect of spiced food on metabolic rate. Hum Nutr Clin Nutr 40(2):165–168
Higashiguchi F, Nakamura H, Hayashi H, Kometani T (2006) Purification and structure determination of glucosides of capsaicin and dihydrocapsaicin from various Capsicum fruits. J Agric Food Chem 54(16):5948–5953
Howard LR, Talcott ST, Brenes CH, Villalon B (2000) Changes in phytochemical and antioxidant activity of selected pepper cultivars (Capsicum species) as influenced by maturity. J Agric Food Chem 48(5):1713–1720
Huang SP, Chen JC, Wu CC, Chen CT, Tang NY, Ho YT, Lo C, Lin JP, Chung JG, Lin JG (2009) Capsaicin-induced apoptosis in human hepatoma HepG2 cells. Anticancer Res 29(1):165–174
Huh HC, Lee SY, Lee SK, Park NH, Han IS (2011) Capsaicin induces apoptosis of cisplatin-resistant stomach cancer cells by causing degradation of cisplatin-inducible Aurora-A protein. Nutr Cancer 63(7):1095–1103
Hursel R, Westerterp-Plantenga MS (2010) Thermogenic ingredients and body weight regulation. Int J Obes (Lond) 34(4):659–669
Huynh HT, Teel RW (2005) In vitro antimutagenicity of capsaicin toward heterocyclic amines in Salmonella typhimurium strain TA98. Anticancer Res 25(1A):117–120
Ip SW, Lan SH, Lu HF, Huang AC, Yang JS, Lin JP, Huang HY, Lien JC, Ho CC, Chiu CF, Wood WG, Chung JG (2012) Capsaicin mediates apoptosis in human nasopharyngeal carcinoma NPC-TW 039 cells through mitochondrial depolarization and endoplasmic reticulum stress. Hum Exp Toxicol 31(6):539–549
Islam MS, Choi H (2008) Dietary red chilli (Capsicum frutescens L.) is insulinotropic rather than hypoglycemic in type 2 diabetes model of rats. Phytother Res 22(8):1025–1029
Jaiarj P, Saichompoo S, Wongkrajang Y, Vongswan N, Peungvicha P, Jiratchariyakul W (1998) Cardiovascular actions of capsaicinoids extract from Thai Capsicum. Thai J Phytopharm 5:1–13
Junior SB, Tavares AM, Filho JT, Zini CI, Godoy HT (2012) Analysis of the volatile compounds of Brazilian chilli peppers (Capsicum spp.) at two stages of maturity by solid phase micro-extraction and gas chromatography-mass spectrometry. Food Res Int 48(1):96–107
Katzer G (2012) Chile (Capsicum frutescens L. and others). http://www.uni-graz.at/∼katzer/engl/Caps_fru.html
Keitel W, Frerick H, Kuhn U, Schmidt U, Kuhlmann M, Bredehorst A (2001) Capsicum pain plaster in chronic non-specific low back pain. Arzneimittelforschung 51(11):896–903
Kempaiah RK, Manjunatha H, Srinivasan K (2005) Protective effect of dietary capsaicin on induced oxidation of low-density lipoprotein in rats. Mol Cell Biochem 275(1–2):7–13
Kim MY (2012) Nitric oxide triggers apoptosis in A375 human melanoma cells treated with capsaicin and resveratrol. Mol Med Report 5(2):585–591
Kim CS, Kawada T, Kim BS, Han IS, Choe SY, Kurata T, Yu R (2003) Capsaicin exhibits anti-inflammatory property by inhibiting IkB-a degradation in LPS-stimulated peritoneal macrophages. Cell Signal 15(3):299–306
Kim JY, Kim EH, Kim SU, Kwon TK, Choi KS (2010) Capsaicin sensitizes malignant glioma cells to TRAIL-mediated apoptosis via DR5 upregulation and survivin downregulation. Carcinogenesis 31(3):367–375
Kosuwon W, Sirichatiwapee W, Wisanuyotin T, Jeeravipoolvarn P, Laupattarakasem W (2010) Efficacy of symptomatic control of knee osteoarthritis with 0.0125% of capsaicin versus placebo. J Med Assoc Thai 93(10):1188–1195
Kozukue N, Han JS, Kozukue E, Lee SJ, Kim JA, Lee KR, Levin CE, Friedman M (2005) Analysis of eight capsaicinoids in peppers and pepper-containing foods by high-performance liquid chromatography and liquid chromatography-mass spectrometry. J Agric Food Chem 53(23):9172–9181
Lawson T, Gannett P (1989) The mutagenicity of capsaicin and dihydrocapsaicin in V79 cells. Cancer Lett 48(2):109–113
Lee JS, Chang JS, Lee JY, Kim JA (2004) Capsaicin-induced apoptosis and reduced release of reactive oxygen species in MBT-2 murine bladder tumor cells. Arch Pharm Res 27(11):1147–1153
Lim K, Yoshioka M, Kikuzato S, Kiyonaga A, Tanaka H, Shindo M, Suzuki M (1979) Dietary red pepper ingestion increases carbohydrate oxidation at rest and during exercise in runners. Med Sci Sports Exerc 29(3):355–361
Liu R, Ke X, Yang CL, Xiong ZD, Zhi ML, Wen TX (2009) Changes in volatile compounds of a native Chinese chilli pepper (Capsicum frutescens var) during ripening. Int J Food Sci Technol 44:2470–2475
Lu HF, Chen YL, Yang JS, Yang YY, Liu JY, Hsu SC, Lai KC, Chung JG (2010) Antitumor activity of capsaicin on human colon cancer cells in vitro and colo 205 tumor xenografts in vivo. J Agric Food Chem 58(24):12999–13005
Luo XJ, Peng J, Li YJ (2011) Recent advances in the study on capsaicinoids and capsinoids. Eur J Pharmacol 650(1):1–7
Lynn B (1990) Capsaicin: actions on nociceptive C-fibres and therapeutic potential. Pain 41(1):61–69
Malagarie-Cazenave S, Olea-Herrero N, Vara D, Morell C, Díaz-Laviada I (2011) The vanilloid capsaicin induces IL-6 secretion in prostate PC-3 cancer cells. Cytokine 54(3):330–337
Manizakiza P, Covaci A, Schepens P (1999) Solid phase extraction and gas chromatography with MS determination of Capsaicin and some of its analogues from chili peppers (Capsicum spp). J AOAC Int 82:1399–1405
Manjunatha H, Srinivasan K (2006) Protective effect of dietary curcumin and capsaicin on induced oxidation of low-density lipoprotein, iron-induced hepatotoxicity and carrageenan-induced inflammation in experimental rats. FEBS J 273(19):4528–4537
Manjunatha H, Srinivasan K (2007a) Hypolipidemic and antioxidant effects of curcumin and capsaicin in high-fat-fed rats. Can J Physiol Pharmacol 85(6):588–596
Manjunatha H, Srinivasan K (2007b) Hypolipidemic and antioxidant effects of dietary curcumin and capsaicin in induced hypercholesterolemic rats. Lipids 42(12):1133–1142
McCarthy GM, McCarthy DJ (1992) Effect of topical capsaicin in the therapy of painful osteoarthritis of the hands. J Rheumatol 19(4):604–607
McCormack PL (2010) Capsaicin dermal patch: in non-diabetic peripheral neuropathic pain. Drugs 70(14):1831–1842
McMahon SB, Lewin G, Bloom SR (1991) The consequences of long-term topical capsaicin application in the rat. Pain 44(3):301–310
Mori A, Lehmann S, O’Kelly J, Kumagai T, Desmond JC, Pervan M, McBride WH, Kizaki M, Koeffler HP (2006) Capsaicin, a component of red peppers, inhibits the growth of androgen-independent, p53 mutant prostate cancer cells. Cancer Res 66(6):3222–3229
Mózsik G, Vincze A, Szolcsányi J (2001) Four response stages of capsaicin-sensitive primary afferent neurons to capsaicin and its analog: gastric acid secretion, gastric mucosal damage and protection. J Gastroenterol Hepatol 16(10):1093–1097
Mózsik G, Szolcsányi J, Rácz I (2005) Gastroprotection induced by capsaicin in healthy human subjects. World J Gastroenterol 11(33):5180–5184
Nagabhushan M, Bhide SV (1985) Mutagenicity of chili extract and capsaicin in short-term tests. Environ Mutagen 7(6):881–888
Ngai PH, Ng TB (2001) A lectin with antifungal and mitogenic activities from red cluster pepper (Capsicum frutescens) seeds. Appl Microbiol Biotechnol 74(2):366–371
Nyren O, Lindberg G, Lindstrom E, Marke LA, Seensalu R (1992) Economic cost of functional dyspepsia. Pharmacoeconomics 1(5):312–324
Oboh G, Ogunruku OO (2010) Cyclophosphamide-induced oxidative stress in brain: protective effect of hot short pepper (Capsicum frutescens L. var. abbreviatum). Exp Toxicol Pathol 62(3):227–233
Oikawa S, Nagao E, Sakano K, Kawanishi S (2006) Mechanism of oxidative DNA damage induced by capsaicin, a principal ingredient of hot chili pepper. Free Radic Res 40(9):966–973
Otero R, Núñez V, Barona J, Fonnegra R, Jiménez SL, Osorio RG, Saldarriaga M, Díaz A (2000) Snakebites and ethnobotany in the northwest region of Colombia. Part III: neutralization of the haemorrhagic effect of Bothrops atrox venom. J Ethnopharmacol 73(1–2):233–241
Pacific Island Ecosystems at Risk (PIER) (2011) Capsicum frutescens L. Solanaceae. http://www.hear.org/pier/species/capsicum_frutescens.htm
Park KK, Surh YJ (1997) Effects of capsaicin on chemically-induced two-stage mouse skin carcinogenesis. Cancer Lett 114(1–2):183–184
Park HS, Kim KS, Min HK, Kim DW (2004) Prevention of postoperative sore throat using capsicum plaster applied at the Korean hand acupuncture point. Anaesthesia 59:647–651
Peppin JF, Majors K, Webster LR, Simpson DM, Tobias JK, Vanhove GF (2011) Tolerability of NGX-4010, a capsaicin 8% patch for peripheral neuropathic pain. J Pain Res 4:385–392
Porcher MH et al (1995–2020) Searchable world wide web multilingual multiscript plant name database. Published by The University of Melbourne, Australia. http://www.plantnames.unimelb.edu.au/Sorting/Frontpage.html
Poulos JM (1994) Capsicum L. In: Siemonsma JS, Piluek K (eds) Plant resources of south-east Asia, no. 8. Vegetables. Pudoc, Wageningen, pp 136–140
Proudlock R, Thompson C, Longstaff E (2004) Examination of the potential genotoxicity of pure capsaicin in bacterial mutation, chromosome aberration, and rodent micronucleus tests. Environ Mol Mutagen 44(5):441–447
Qin HJ, Lin CW, Jiang LB, Zhong YM, Huang KJ (2004) The GC/MS analysis of the chemical components of oil from Capsicum. Frontier Separ Sci Technol. In: Proceedings of the 4th international conference nanning, Guangxi, China, 18–21 Feb 2004, pp 485–486
Quijano CE, Pino JA (2010) Volatile compounds of Capsicum frutescens L. cultivars from Colombia. J Essent Oil Res 22(6):503–506
Rau O, Wurglics M, Dingermann T, Abdel-Tawab M, Schubert-Zsilavecz M (2006) Screening of herbal extracts for activation of the human peroxisome proliferator-activated receptor. Pharmazie 61(11):952–956
Renault S, De Lucca AJ, Boue S, Bland JM, Vigo CB, Selitrennikoff CP (2003) CAY-1, a novel antifungal compound from cayenne pepper. Med Mycol 41(1):75–81
Reuter J, Wölfle U, Weckesser S, Schempp C (2010) Which plant for which skin disease? Part 1: atopic dermatitis, psoriasis, acne, condyloma and herpes simplex. J Dtsch Dermatol Ges 8(10):788–796
Rodríguez-Burruezo A, Kollmannsberger H, González-Mas MC, Nitz S, Fernando N (2010) HS-SPME comparative analysis of genotypic diversity in the volatile fraction and aroma-contributing compounds of Capsicum fruits from the annuum-chinense-frutescens complex. J Agric Food Chem 58(7):4388–4400
Rodriguez-Stanley S, Collings KL, Robinson M, Owen W, Miner PB Jr (2000) The effects of capsaicin on reflux, gastric emptying and dyspepsia. Aliment Pharmacol Ther 14(1):129–134
Rothwell NJ, Stock MJ (1981) A role for insulin in the diet-induced thermogenesis of cafeteria-fed rats. Metabolism 30(7):673–678
Sambo N, Odeh SO, Ibu JO, Onyikwola O (2007) The effects of Capsicum annuum and Capsicum frutescens-induced gastric acid secretion in the rat is by H2 receptor stimulation. Highland Med Res J 5(2):38–41
Serra I, Yamamoto M, Calvo A, Cavada G, Báez S, Endoh K, Watanabe H, Tajima K (2002) Association of chili pepper consumption, low socioeconomic status and longstanding gallstones with gallbladder cancer in a Chilean population. Int J Cancer 102(4):407–411
Shubha MC, Reddy RR, Srinivasan K (2011) Antilithogenic influence of dietary capsaicin and curcumin during experimental induction of cholesterol gallstone in mice. Appl Physiol Nutr Metab 36(2):201–209
Simpson DM, Gazda S, Brown S, Webster LR, Lu SP, Tobias JK, Vanhove GF, NGX-4010 C118 Study Group (2010) Long-term safety of NGX-4010, a high-concentration capsaicin patch, in patients with peripheral neuropathic pain. J Pain Symptom Manage 39(6):1053–1064
Singh S, Jarret R, Russo V, Majetich G, Shimkus J, Bushway R, Perkins B (2009) Determination of capsinoids by HPLC-DAD in Capsicum species. J Agric Food Chem 57(9):3452–3457
Smith AC (1991) Flora Vitiensis nova: a new flora of Fiji, vol 5. National Tropical Botanical Garden, Lawai, 626 pp
Solanke TF, Ayeni O, Osanyintuyi SO (1976) Effect of a mixture of red pepper (Capsicum frutescens) and an amino-acid on gastric acid secretion. Niger Med J 6(1):23–25
Stergiopoulou T, De Lucca AJ, Meletiadis J, Sein T, Boue SM, Schaufele R, Roilides E, Ghannoum M, Walsh TJ (2008) In vitro activity of CAY-1, a saponin from Capsicum frutescens, against Microsporum and Trichophyton species. Med Mycol 46(8):805–810
Stuart M (ed) (1987) The encyclopedia of herbs and herbalism. Crescent, London, 304 pp
Stuart GU (2011) Philippine alternative medicine. Manual of Some Philippine Medicinal Plants. http://www.stuartxchange.org/OtherHerbals.html
Surh YJ (2002) Anti-tumor promoting potential of selected spice ingredients with antioxidative and anti-inflammatory activities: a short review. Food Chem Toxicol 40(8):1091–1097
Surh YJ, Lee SS (1995) Capsaicin, a double-edged sword: toxicity, metabolism, and chemopreventive potential. Life Sci 56(22):1845–1855
Szolcsányi J, Barthó L (2001) Capsaicin-sensitive afferents and their role in gastroprotection: an update. J Physiol Paris 95(1–6):181–188
Takeuchi K, Tachibana K, Ueshima K, Matsumoto J, Okabe S (1992) Stimulation by capsaicin of gastric alkaline secretion in anesthetized rats. Jpn J Pharmacol 59(2):151–157
Tanaka Y, Hosokawa M, Otsu K, Watanabe T, Yazawa S (2009) Assessment of capsiconinoid composition, nonpungent capsaicinoid analogues, in Capsicum cultivars. J Agric Food Chem 57(12):5407–5412
Tee ES, Noor MI, Azudin MN, Idris K (1997) Nutrient composition of Malaysian foods, 4th edn. Institute for Medical Research, Kuala Lumpur, p 299
Tesfaye S, Vileikyte L, Rayman G, Sindrup S, Perkins B, Baconja M, Vinik A, Boulton A, Toronto Expert Panel on Diabetic Neuropathy (2011) Painful diabetic peripheral neuropathy: consensus recommendations on diagnosis, assessment and management. Diabetes Metab Res Rev 27:629–638
Thoennissen NH, O’Kelly J, Lu D, Iwanski GB, La DT, Abbassi S, Leiter A, Karlan B, Mehta R, Koeffler HP (2010) Capsaicin causes cell-cycle arrest and apoptosis in ER-positive and -negative breast cancer cells by modulating the EGFR/HER-2 pathway. Oncogene 29(2):285–296
Tolan I, Ragoobirsingh D, Morrison EY (2001) The effect of capsaicin on blood glucose, plasma insulin levels and insulin binding in dog models. Phytother Res 15(5):391–394
Tolan I, Ragoobirsingh D, Morrison EY (2004) Isolation and purification of the hypoglycaemic principle present in Capsicum frutescens. Phytother Res 18(1):95–96
Toth B, Rogan E, Walker B (1984) Tumorigenicity and mutagenicity studies with capsaicin of hot peppers. Anticancer Res 4(3):117–119
Tsuchiya Y, Terao M, Okano K, Nakamura K, Oyama M, Ikegami K, Yamamoto M (2011) Mutagenicity and mutagens of the red chili pepper as gallbladder cancer risk factor in Chilean women. Asian Pac J Cancer Prev 12(2):471–476
Uchida M, Yano S, Watanabe K (1991) The role of capsaicin-sensitive afferent nerves in protective effect of capsaicin against absolute ethanol-induced gastric lesions in rats. Jpn J Pharmacol 55(2):279–282
U.S. Department of Agriculture, Agricultural Research Service (USDA) (2012) USDA National Nutrient Database for Standard Reference, Release 25, Nutrient Data Laboratory Home Page, http://www.ars.usda.gov/ba/bhnrc/ndl
van Wyk CW, Olivier A, de Miranda C, van der Bijl P, Grobler-Rabie AF, Chalton DO (1995) Effect of chilli (Capsicum frutescens) extract on proliferation of oral mucosal fibroblasts. Indian J Exp Biol 33(4):244–248
Villaseñor IM, de Ocampo EJ (1994) Clastogenicity of red pepper (Capsicum frutescens L.) extracts. Mutat Res 312(2):151–155
Vinayaka KS, Nandini KC, Rakshitha MN, Martis R, Shruthi J, Hegde SV, Kekuda TR, Raghavendra HL (2010) Proximate composition, antibacterial and anthelmintic activity of Capsicum frutescens (L.) var. longa (Solanaceae) leaves. Pharmacogn J 2(12):486–491
Wagner WL, Herbst DR, Sohmer SH (1999) Manual of the flowering plants of Hawaii, 2 vols, Rev edn. Bernice P. Bishop Museum special publication. University of Hawai‘i Press/Bishop Museum Press, Honolulu, 1919 pp
Wallace M, Pappagallo M (2011) Qutenza®: a capsaicin 8% patch for the management of postherpetic neuralgia. Expert Rev Neurother 11(1):15–27
Wang JP, Hsu MF, Hsu TP, Teng CM (1985) Antihemostatic and antithrombotic effects of capsaicin in comparison with aspirin and indomethacin. Thromb Res 37(6):669–679
Wu CC, Lin JP, Yang JS, Chou ST, Chen SC, Lin YT, Lin HL, Chung JG (2006) Capsaicin induced cell cycle arrest and apoptosis in human esophagus epidermoid carcinoma CE 81 T/VGH cells through the elevation of intracellular reactive oxygen species and Ca(2+) productions and caspase-3 activation. Mutat Res 601(2):71–82
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© 2013 Springer Science+Business Media Dordrecht
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Lim, T.K. (2013). Capsicum frutescens. In: Edible Medicinal And Non-Medicinal Plants. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5628-1_31
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DOI: https://doi.org/10.1007/978-94-007-5628-1_31
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