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MicroRNA Cancer Regulation pp 267–290Cite as

Discovering Functional microRNA-mRNA Regulatory Modules in Heterogeneous Data

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 774))

Abstract

microRNAs (miRNAs) are small non-coding RNAs that cause mRNA degradation and translation inhibition. They are pivotal regulators of development and cellular homeostasis through their control of diverse processes. Recently, great efforts have been made to elucidate many targets that are affected by miRNAs, but the functions of most miRNAs and their precise regulatory mechanisms remain elusive. With more and more matched expression profiles of miRNAs and mRNAs having been made available, it is of great interest to utilize both expression profiles and sequence information to discover the functional regulatory networks of miRNAs and their target mRNAs for potential biological processes that they may participate in. In this chapter, we first briefly review the computational methods for discovering miRNA targets and miRNA-mRNA regulatory modules, and then focus on a method of identifying functional miRNA-mRNA regulatory modules by integrating multiple data sets from different sources.

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Acknowledgement

We thank Dr Jeffrey E. Green and Dr. Min Zhu for providing the data sets.

Author information

Authors and Affiliations

  1. Children’s Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, University of New South Wales, High St., Randwick, NSW, 2031, Australia

    Bing Liu

  2. School of Computer and Information Science, University of South Australia, Adelaide, SA, Australia

    Lin Liu & Jiuyong Li

  3. Centre for Cancer Biology, SA Pathology, Adelaide, SA, Australia

    Anna Tsykin & Gregory J. Goodall

  4. School of Molecular and Biomedical Science and Department of Medicine, University of Adelaide, Adelaide, SA, Australia

    Gregory J. Goodall

  5. School of Biomedical Sciences and Pharmacy, Faculty of Health, University of Newcastle, Newcastle, NSW, Australia

    Murray J. Cairns

Authors
  1. Bing Liu
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  2. Lin Liu
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  3. Anna Tsykin
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  4. Gregory J. Goodall
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  5. Murray J. Cairns
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  6. Jiuyong Li
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Corresponding authors

Correspondence to Bing Liu or Jiuyong Li .

Editor information

Editors and Affiliations

  1. Systems Biology and Bioinformatics, University of Rostock, Rostock, Germany

    Ulf Schmitz

  2. Dept. of Systems Biology and Bioinformat, Universität Rostock Institut of Computer Science, Rostock, Germany

    Olaf Wolkenhauer

  3. Rostock, Germany

    Julio Vera

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Liu, B., Liu, L., Tsykin, A., Goodall, G.J., Cairns, M.J., Li, J. (2013). Discovering Functional microRNA-mRNA Regulatory Modules in Heterogeneous Data. In: Schmitz, U., Wolkenhauer, O., Vera, J. (eds) MicroRNA Cancer Regulation. Advances in Experimental Medicine and Biology, vol 774. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5590-1_14

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