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Gene Duplication and Functional Consequences

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Book cover Applied Computational Genomics

Part of the book series: Translational Bioinformatics ((TRBIO,volume 1))

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Abstract

Due to genome-wide or local chromosome duplication events, in almost all organisms, many genes are represented as several paralogs (duplicate genes) in the genome with related but distinct functions (gene families). After accumulating mutations in coding sequences and regulatory regions, duplicate genes may have more opportunity to diversify in protein function and/or regulatory network, leading to an increase of organismal complexity. With the explosive increase of high-throughput data, however, it has been realized that gene duplication is a much more complicated process, and the underlying mechanisms may vary considerably in different organisms. In this chapter, we shall focus on a few important issues related to copy-number variation, gene essentiality, transcriptional, and epigenetic divergence between duplicate genes.

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Authors and Affiliations

  1. Department of Genetics, Development and Cell Biology-Genetics, Center for Bioinformatics and Biological Statistics, Iowa State University, Ames, IA, 50011, USA

    Xun Gu

  2. School of Life Sciences, Center for Evolutionary Biology, Fudan University, Shanghai, 200433, China

    Yangyun Zou & Zhixi Su

Authors
  1. Xun Gu
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  2. Yangyun Zou
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  3. Zhixi Su
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Correspondence to Xun Gu .

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  1. 35 Convent Drive, Bethesda, 20892, USA

    Yin Yao Shugart

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Gu, X., Zou, Y., Su, Z. (2012). Gene Duplication and Functional Consequences. In: Shugart, Y. (eds) Applied Computational Genomics. Translational Bioinformatics, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5558-1_9

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